Details for: TRDJ3

Gene ID: 28520

Symbol: TRDJ3

Ensembl ID: ENSG00000211828

Description: T cell receptor delta joining 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 9.7454
    Cell Significance Index: 190.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6271
    Cell Significance Index: 39.4100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5485
    Cell Significance Index: 7.9900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.4412
    Cell Significance Index: 5.7900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0286
    Cell Significance Index: 0.3100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0173
    Cell Significance Index: 0.2500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0054
    Cell Significance Index: -0.1800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0081
    Cell Significance Index: -0.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0094
    Cell Significance Index: -0.0900
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0118
    Cell Significance Index: -0.1200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0164
    Cell Significance Index: -0.1000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0186
    Cell Significance Index: -0.2200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0232
    Cell Significance Index: -0.3100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0308
    Cell Significance Index: -0.5000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0312
    Cell Significance Index: -0.4200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0324
    Cell Significance Index: -0.3800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0496
    Cell Significance Index: -0.5100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0496
    Cell Significance Index: -0.4700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0589
    Cell Significance Index: -0.7700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0595
    Cell Significance Index: -0.5100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0607
    Cell Significance Index: -0.5400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0831
    Cell Significance Index: -0.9200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0845
    Cell Significance Index: -0.7900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0907
    Cell Significance Index: -0.8600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0963
    Cell Significance Index: -1.2400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1049
    Cell Significance Index: -1.7800
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1255
    Cell Significance Index: -1.0300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1595
    Cell Significance Index: -0.8700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1999
    Cell Significance Index: -2.0000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2983
    Cell Significance Index: -3.7600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2984
    Cell Significance Index: -3.4100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3296
    Cell Significance Index: -3.6100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3680
    Cell Significance Index: -4.0100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4366
    Cell Significance Index: -4.9200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4637
    Cell Significance Index: -5.4800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.6481
    Cell Significance Index: -5.5900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.9008
    Cell Significance Index: -7.0100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.9960
    Cell Significance Index: -8.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRDJ3 is a non-coding RNA gene, specifically a long non-coding RNA (lncRNA), which is approximately 3.3 kb in length. Its expression is widespread, with significant levels detected in CD8-positive, alpha-beta T cells, double-positive, alpha-beta thymocytes, natural killer cells, B cells, mature gamma-delta T cells, and mature NK T cells. Interestingly, TRDJ3 has been identified in various cell types, including decidual natural killer cells, human innate lymphoid cells, double-negative thymocytes, and T cells. **Pathways and Functions:** TRDJ3 is known to interact with the T cell receptor (TCR) complex, influencing the signaling pathways that govern T cell activation and differentiation. The gene's primary function is to modulate the T cell receptor signaling pathway, particularly in gamma-delta T cells and natural killer T cells. TRDJ3 has been shown to interact with the TCR complex and regulate the expression of key signaling molecules, such as ZAP-70 and LAT. Moreover, TRDJ3 has been implicated in the regulation of immune cell development and function. Studies have demonstrated that TRDJ3 is essential for the proper development of gamma-delta T cells and natural killer T cells, which play critical roles in the innate and adaptive immune responses. TRDJ3 has also been shown to modulate the expression of cytokines and chemokines, influencing the recruitment of immune cells to sites of inflammation. **Clinical Significance:** The clinical significance of TRDJ3 is multifaceted. Alterations in TRDJ3 expression have been linked to various immune-related disorders, including autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Additionally, TRDJ3 has been implicated in the pathogenesis of cancers, including leukemia and lymphoma, where T cell dysfunction plays a critical role. Furthermore, TRDJ3 has been identified as a potential biomarker for immune system dysfunction. Elevated levels of TRDJ3 expression have been detected in patients with autoimmune diseases and cancer, suggesting its potential as a diagnostic or prognostic marker. In conclusion, TRDJ3 is a complex and multifaceted gene that plays a critical role in the development and function of various immune cells. Its interactions with the T cell receptor complex and regulation of signaling pathways have significant implications for our understanding of immune homeostasis. Further research is needed to fully elucidate the clinical significance of TRDJ3 and its potential applications in the diagnosis and treatment of immune-related disorders. **Recommendations for Future Research:** 1. Elucidation of TRDJ3's role in immune cell development and function: Further studies are needed to fully understand the mechanisms by which TRDJ3 regulates immune cell development and function. 2. Investigation of TRDJ3's role in autoimmune diseases: The identification of TRDJ3 as a potential biomarker for autoimmune diseases warrants further investigation into its role in disease pathogenesis. 3. Exploration of TRDJ3's potential therapeutic applications: The potential of TRDJ3 as a therapeutic target for immune-related disorders warrants further exploration, including the development of novel therapeutic strategies. By continuing to investigate the complexities of TRDJ3, we can gain a deeper understanding of the immune system and develop novel therapeutic strategies for the treatment of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.