Details for: TRDJ2

Gene ID: 28521

Symbol: TRDJ2

Ensembl ID: ENSG00000211827

Description: T cell receptor delta joining 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 7.3498
    Cell Significance Index: 143.7000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3143
    Cell Significance Index: 31.8400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3650
    Cell Significance Index: 5.3200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3160
    Cell Significance Index: 4.1500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1713
    Cell Significance Index: 2.7700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.0071
    Cell Significance Index: 0.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0006
    Cell Significance Index: 0.2300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0071
    Cell Significance Index: -0.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0097
    Cell Significance Index: -0.3200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0118
    Cell Significance Index: -0.2000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0181
    Cell Significance Index: -0.2200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0193
    Cell Significance Index: -0.2300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0220
    Cell Significance Index: -0.4400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0233
    Cell Significance Index: -0.2500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0243
    Cell Significance Index: -0.2900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0283
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0311
    Cell Significance Index: -0.2900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0332
    Cell Significance Index: -0.4500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0337
    Cell Significance Index: -0.4500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0343
    Cell Significance Index: -0.3300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0356
    Cell Significance Index: -0.4800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0359
    Cell Significance Index: -0.3800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0385
    Cell Significance Index: -0.4100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0389
    Cell Significance Index: -0.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0405
    Cell Significance Index: -0.6900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0435
    Cell Significance Index: -0.4400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0438
    Cell Significance Index: -0.3900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0447
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0465
    Cell Significance Index: -0.4400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0475
    Cell Significance Index: -0.4900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0479
    Cell Significance Index: -0.5400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0498
    Cell Significance Index: -0.4700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0502
    Cell Significance Index: -0.4700
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0597
    Cell Significance Index: -0.4900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0640
    Cell Significance Index: -0.4100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0917
    Cell Significance Index: -0.5000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0931
    Cell Significance Index: -1.1000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1275
    Cell Significance Index: -1.1000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1346
    Cell Significance Index: -1.4800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1451
    Cell Significance Index: -1.4500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1632
    Cell Significance Index: -1.8900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1848
    Cell Significance Index: -1.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRDJ2 is a gene that belongs to the delta joining (DJ) family, which is characterized by the presence of a conserved DJ domain. This domain is crucial for the proper assembly and function of T cell receptors (TCRs). TRDJ2 is specifically expressed in CD8-positive, alpha-beta T cells, as well as in other immune cells such as natural killer cells, B cells, and innate lymphoid cells. The expression of TRDJ2 is also observed in human decidual natural killer cells, which are involved in maintaining pregnancy and immune tolerance. **Pathways and Functions:** TRDJ2 is involved in the regulation of immune cell development, differentiation, and function. Specifically, TRDJ2 has been shown to: 1. **Regulate TCR assembly and function**: TRDJ2 is essential for the proper assembly and function of alpha-beta TCRs, which are critical for the recognition and elimination of pathogens. 2. **Influence natural killer cell function**: TRDJ2 is expressed in natural killer cells and has been implicated in regulating their cytotoxic activity and cytokine production. 3. **Modulate B cell development and function**: TRDJ2 is also expressed in B cells and has been shown to influence their development, differentiation, and antibody production. 4. **Regulate innate lymphoid cell function**: TRDJ2 is expressed in innate lymphoid cells and has been implicated in regulating their function and cytokine production. **Clinical Significance:** The significance of TRDJ2 in human health and disease is an area of ongoing research. While TRDJ2 is not directly associated with any specific diseases, its dysregulation has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: TRDJ2 dysregulation has been linked to autoimmune diseases such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: TRDJ2 expression has been observed in certain types of cancer, including leukemia and lymphoma. 3. **Infectious diseases**: TRDJ2 has been implicated in regulating immune responses to infections, particularly those caused by viruses and bacteria. In conclusion, TRDJ2 is a gene of ongoing research in immunology, and its specific mechanisms and clinical implications are yet to be fully elucidated. Further studies are needed to elucidate the role of TRDJ2 in immune cell development, differentiation, and function, as well as its potential involvement in various immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.