Details for: TRBV23OR9 2

Gene ID: 28552

Symbol: TRBV23OR9 2

Ensembl ID: ENSG00000229063

Description: T cell receptor beta variable 23/OR9-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0052
    Cell Significance Index: 0.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0030
    Cell Significance Index: 0.0300
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0014
    Cell Significance Index: -0.2800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0049
    Cell Significance Index: -0.1000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0066
    Cell Significance Index: -0.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0069
    Cell Significance Index: -0.2200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0077
    Cell Significance Index: -0.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0088
    Cell Significance Index: -0.2200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0092
    Cell Significance Index: -0.1000
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0095
    Cell Significance Index: -0.1100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0106
    Cell Significance Index: -0.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0114
    Cell Significance Index: -0.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0118
    Cell Significance Index: -0.2300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0124
    Cell Significance Index: -0.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0128
    Cell Significance Index: -0.2700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0139
    Cell Significance Index: -0.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0184
    Cell Significance Index: -0.2300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0188
    Cell Significance Index: -0.2500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0189
    Cell Significance Index: -0.2100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0191
    Cell Significance Index: -0.1700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0198
    Cell Significance Index: -0.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0203
    Cell Significance Index: -0.2500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0217
    Cell Significance Index: -0.2200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0224
    Cell Significance Index: -0.2400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0246
    Cell Significance Index: -0.2300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0252
    Cell Significance Index: -0.2200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0307
    Cell Significance Index: -0.2000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0443
    Cell Significance Index: -0.2800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0489
    Cell Significance Index: -0.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV23OR9-2 is a pseudogene, meaning it lacks the functional coding potential to produce a protein. However, its presence in the genome suggests that it may have evolved from a functional gene that has since undergone pseudogenization. The gene is significantly expressed in epithelial cells, double-negative thymocytes, stromal cells, neurons, pancreatic acinar cells, retinal cone cells, and L2/3-6 intratelencephalic projecting glutamatergic neurons. This widespread expression across different cell types raises questions about the functional significance of TRBV23OR9-2 and its potential role in regulating cellular processes. **Pathways and Functions:** While TRBV23OR9-2 lacks the coding potential for a functional protein, its expression in various cell types suggests that it may be involved in regulating cellular signaling pathways. Research has shown that TRBV23OR9-2 is co-expressed with other genes involved in cell signaling, such as signaling pathway molecules and transcription factors. This co-expression pattern implies that TRBV23OR9-2 may play a role in modulating cellular responses to environmental stimuli. Additionally, the gene's expression in neurons and retinal cone cells suggests that it may be involved in the regulation of neural development and function. **Clinical Significance:** The clinical significance of TRBV23OR9-2 is still unclear, but its expression in various cell types raises several possibilities. For example, the gene's presence in epithelial cells may be related to the maintenance of epithelial barrier function, while its expression in neurons may be involved in the regulation of neural development and function. Furthermore, the gene's co-expression with other genes involved in cell signaling suggests that it may be involved in the regulation of immune responses. Further research is needed to fully understand the clinical significance of TRBV23OR9-2 and its potential role in human disease. In conclusion, TRBV23OR9-2 is a pseudogene that exhibits unique characteristics and is significantly expressed in various cell types. While its functional coding potential is lacking, its co-expression with other genes involved in cell signaling suggests that it may play a role in regulating cellular processes. Further research is needed to fully understand the clinical significance of TRBV23OR9-2 and its potential role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.