Details for: TRAJ43

Gene ID: 28712

Symbol: TRAJ43

Ensembl ID: ENSG00000211846

Description: T cell receptor alpha joining 43

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.8755
    Cell Significance Index: 36.3300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0033
    Cell Significance Index: -0.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0072
    Cell Significance Index: -0.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0161
    Cell Significance Index: -0.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0178
    Cell Significance Index: -0.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0237
    Cell Significance Index: -0.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0243
    Cell Significance Index: -0.2900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0247
    Cell Significance Index: -0.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0254
    Cell Significance Index: -0.4700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0297
    Cell Significance Index: -0.5800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0319
    Cell Significance Index: -0.3600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0338
    Cell Significance Index: -0.4200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0354
    Cell Significance Index: -0.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0364
    Cell Significance Index: -0.3500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0380
    Cell Significance Index: -0.3900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0388
    Cell Significance Index: -0.4500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0397
    Cell Significance Index: -0.4400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0398
    Cell Significance Index: -0.4700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0411
    Cell Significance Index: -0.3900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0423
    Cell Significance Index: -0.5700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0424
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0434
    Cell Significance Index: -0.4000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0437
    Cell Significance Index: -0.4400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0439
    Cell Significance Index: -0.4700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0440
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0463
    Cell Significance Index: -0.4700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0465
    Cell Significance Index: -0.6000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0469
    Cell Significance Index: -0.6200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0474
    Cell Significance Index: -0.4300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0481
    Cell Significance Index: -0.4500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0500
    Cell Significance Index: -0.4600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0501
    Cell Significance Index: -0.4200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0512
    Cell Significance Index: -0.4500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0517
    Cell Significance Index: -0.5800
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0524
    Cell Significance Index: -0.4300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0528
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0532
    Cell Significance Index: -0.5400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0533
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0580
    Cell Significance Index: -0.4700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0582
    Cell Significance Index: -0.4700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0606
    Cell Significance Index: -0.5200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0628
    Cell Significance Index: -0.5700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0669
    Cell Significance Index: -0.4600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0711
    Cell Significance Index: -0.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Diverse Expression Patterns:** TRAJ43 is expressed in a variety of immune cells, including CD4-positive and CD8-positive T cells, B cells, innate lymphoid cells, and thymocytes. Its expression is notable in alpha-beta T cells, which are a crucial component of the adaptive immune system. 2. **Gene Structure:** The TRAJ43 gene consists of a single exon, which encodes a protein with a relatively short sequence of 143 amino acids. This compact structure suggests a specific and highly regulated function. 3. **Cell-Specific Expression:** TRAJ43 is predominantly expressed in cells of the immune system, with lower levels detected in retinal rod cells. This dichotomy highlights the gene's unique role in immune cell biology. **Pathways and Functions:** 1. **T Cell Receptor Signaling:** TRAJ43 is involved in the signaling pathway of the T cell receptor (TCR), which is essential for the activation and proliferation of T cells. The protein's role in TCR signaling is thought to be mediated through its interaction with other TCR components. 2. **Thymocyte Development:** TRAJ43 plays a critical role in the development of thymocytes, which are precursor cells to mature T cells. The protein's expression in thymocytes suggests its involvement in the maturation process. 3. **Immune Cell Proliferation:** TRAJ43's expression in T cells, B cells, and innate lymphoid cells implies its role in the proliferation and activation of these cells, which are essential for immune responses. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of TRAJ43 has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where T cell dysfunction plays a key role. 2. **Cancer Immunotherapy:** TRAJ43's expression in T cells and other immune cells suggests its potential involvement in cancer immunotherapy. Targeting TRAJ43 could provide a novel approach to modulating the immune response against cancer. 3. **Immunodeficiency Disorders:** TRAJ43's role in T cell development and function highlights its importance in immunodeficiency disorders, such as severe combined immunodeficiency (SCID). Understanding the mechanisms underlying TRAJ43's function could lead to the development of novel therapies for these conditions. In conclusion, TRAJ43 is a gene with diverse expression patterns and essential roles in immune cell development and function. Its involvement in T cell receptor signaling, thymocyte development, and immune cell proliferation underscores its critical importance in immune biology. Further research is necessary to elucidate the mechanisms underlying TRAJ43's function and its clinical significance in autoimmune diseases, cancer immunotherapy, and immunodeficiency disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.