**Key characteristics:**
* The IGKV1OR2 pseudogene is a large gene with a complex structure.
* It contains multiple alternatively spliced exons that encode different isoforms of the protein.
* The protein is expressed in a wide range of cell types, including plasma cells, plasmablast cells, and epithelial cells of the lung.
* It is significantly expressed in cells of the immune system, particularly in plasma cells and plasmablast cells.
**Pathways and functions:**
* The IGKV1OR2 protein is expressed on the surface of plasma cells and plasmablast cells, where it is involved in the recognition of pathogens.
* It is also expressed on epithelial cells of the lung, where it may play a role in the regulation of inflammation.
* The protein is a member of the immunoglobulin kappa family of cell surface receptors, which are involved in the recognition of antigens.
* It is expressed in high levels on plasma cells and plasmablast cells, which are the first cells to recognize pathogens.
* The protein is also expressed on B cells, memory B cells, naive B cells, CD8-positive T cells, and T cells, suggesting that it is involved in both humoral and cell-mediated immunity.
**Clinical significance:**
The IGKV1OR2 pseudogene has been linked to several human diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. Studies have shown that mutations in the IGKV1OR2 gene can lead to the development of these diseases. These findings suggest that the IGKV1OR2 protein is a key player in the pathogenesis of these diseases.
Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
