Details for: IGKV1OR2 1

Gene ID: 3531

Symbol: IGKV1OR2 1

Ensembl ID: ENSG00000235235

Description: immunoglobulin kappa variable 1/OR2-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0060
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0072
    Cell Significance Index: -0.0800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0074
    Cell Significance Index: -0.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0081
    Cell Significance Index: -0.3600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0101
    Cell Significance Index: -0.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0122
    Cell Significance Index: -0.2500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0152
    Cell Significance Index: -0.1600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0157
    Cell Significance Index: -0.1400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0166
    Cell Significance Index: -0.1800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0175
    Cell Significance Index: -0.1600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0191
    Cell Significance Index: -0.2400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0196
    Cell Significance Index: -0.2100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0216
    Cell Significance Index: -0.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0248
    Cell Significance Index: -0.1500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0254
    Cell Significance Index: -0.2400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0255
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0257
    Cell Significance Index: -0.2400
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0258
    Cell Significance Index: -0.2200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0265
    Cell Significance Index: -0.4500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0277
    Cell Significance Index: -0.3500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0285
    Cell Significance Index: -0.3400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0289
    Cell Significance Index: -0.3400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0302
    Cell Significance Index: -0.3600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0303
    Cell Significance Index: -0.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0314
    Cell Significance Index: -0.3700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0340
    Cell Significance Index: -0.3000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0388
    Cell Significance Index: -0.4200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0438
    Cell Significance Index: -0.3600
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0441
    Cell Significance Index: -0.3200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0446
    Cell Significance Index: -0.3700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0490
    Cell Significance Index: -0.4600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0498
    Cell Significance Index: -0.6100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0525
    Cell Significance Index: -0.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGKV1OR2 is a pseudogene, meaning it lacks the functional coding potential of its parent gene. Its pseudogenetic nature suggests that it may have evolved from a functional gene that has since lost its coding capacity. 2. **Diverse expression patterns:** IGKV1OR2 is expressed in a wide range of cell types, including IgA plasma cells, plasmablasts, plasma cells, B cells, memory B cells, naive B cells, CD8-positive T cells, alpha-beta T cells, and epithelial cells of the lung. 3. **Lack of clear functional annotation:** Despite its widespread expression, the functional role of IGKV1OR2 remains unclear. Its expression in immune cells, however, suggests that it may be involved in immune regulation or signaling pathways. **Pathways and Functions:** 1. **Immune cell development and activation:** IGKV1OR2's expression in B cells, plasmablasts, and plasma cells suggests that it may play a role in the development and activation of these cells. Its presence in T cells further supports the idea that IGKV1OR2 may be involved in immune regulation. 2. **Signaling pathways:** IGKV1OR2's pseudogenetic nature may have led to the formation of non-canonical signaling pathways that are distinct from those mediated by functional immunoglobulins. Further investigation is needed to elucidate the specific signaling pathways involved. 3. **Epithelial cell function:** IGKV1OR2's expression in epithelial cells of the lung raises questions about its potential role in lung immunity and disease. Further studies are warranted to explore the functional significance of IGKV1OR2 in this context. **Clinical Significance:** 1. **Immunological dysregulation:** IGKV1OR2's expression in immune cells and its potential involvement in signaling pathways suggest that dysregulation of this gene may contribute to immune-related diseases, such as autoimmune disorders or cancer. 2. **Lung disease:** IGKV1OR2's expression in epithelial cells of the lung raises concerns about its potential role in lung diseases, such as chronic obstructive pulmonary disease (COPD) or lung cancer. 3. **Cancer immunology:** IGKV1OR2's expression in T cells and its potential involvement in signaling pathways may make it a valuable target for cancer immunotherapy. In conclusion, the IGKV1OR2 gene presents a fascinating enigma in the field of immunology. Further investigation into its expression patterns, signaling pathways, and functional implications is necessary to fully understand its role in immune regulation and disease. As our knowledge of this pseudogene continues to grow, it is likely to shed light on the complex mechanisms underlying immune function and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.