Details for: SNORD35A

Gene ID: 26816

Symbol: SNORD35A

Ensembl ID: ENSG00000200259

Description: small nucleolar RNA, C/D box 35A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0576
    Cell Significance Index: 0.6900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0140
    Cell Significance Index: 0.1200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0033
    Cell Significance Index: -0.9400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0095
    Cell Significance Index: -0.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0163
    Cell Significance Index: -0.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0239
    Cell Significance Index: -0.2600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0249
    Cell Significance Index: -0.3300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0250
    Cell Significance Index: -0.3100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0274
    Cell Significance Index: -0.3700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0302
    Cell Significance Index: -0.2300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0304
    Cell Significance Index: -0.3300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0353
    Cell Significance Index: -0.4400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0355
    Cell Significance Index: -0.4400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0356
    Cell Significance Index: -0.2900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0357
    Cell Significance Index: -0.4500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0569
    Cell Significance Index: -0.6500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0634
    Cell Significance Index: -0.6800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0686
    Cell Significance Index: -0.6300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0708
    Cell Significance Index: -0.8100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0720
    Cell Significance Index: -0.9400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0779
    Cell Significance Index: -0.9200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0782
    Cell Significance Index: -0.9200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0804
    Cell Significance Index: -0.9700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0815
    Cell Significance Index: -0.9600
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0822
    Cell Significance Index: -0.5700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0829
    Cell Significance Index: -0.9800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0844
    Cell Significance Index: -0.9800
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0857
    Cell Significance Index: -0.8500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0867
    Cell Significance Index: -1.0300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0880
    Cell Significance Index: -0.9700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0895
    Cell Significance Index: -1.0700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0899
    Cell Significance Index: -0.9800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0920
    Cell Significance Index: -1.0100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0924
    Cell Significance Index: -1.0500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0939
    Cell Significance Index: -1.0400
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.1028
    Cell Significance Index: -1.0500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1072
    Cell Significance Index: -1.1100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1112
    Cell Significance Index: -0.9800
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1135
    Cell Significance Index: -1.1100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1233
    Cell Significance Index: -1.0200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1343
    Cell Significance Index: -1.0500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1389
    Cell Significance Index: -1.1300
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.1700
    Cell Significance Index: -0.8200
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.4015
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD35A is a small nucleolar RNA (snoRNA) molecule, approximately 100-150 nucleotides in length. It belongs to the C/D box family of snoRNAs, which are involved in regulating RNA processing and ribosome biogenesis. SNORD35A exhibits a characteristic C/D box motif, which is essential for its function. The expression of SNORD35A is widespread, with significant levels found in plasma cells, pericytes, cardiac endothelial cells, and other cell types involved in immune regulation and cellular differentiation. **Pathways and Functions:** The functions of SNORD35A are not fully understood, but its expression in various cell types suggests that it plays a role in regulating RNA processing and nucleolus formation. SNORD35A is involved in the following pathways: 1. **RNA processing:** SNORD35A is involved in regulating the processing of pre-rRNA, which is essential for ribosome biogenesis. It binds to specific sequences in the pre-rRNA, leading to the formation of mature ribosomal subunits. 2. **Nucleolus formation:** SNORD35A is involved in the formation of the nucleolus, a region within the nucleus where ribosome biogenesis occurs. The nucleolus is essential for cellular growth and proliferation. 3. **Immune regulation:** SNORD35A is expressed in plasma cells, which are key players in the adaptive immune response. SNORD35A may play a role in regulating the expression of immune-related genes in these cells. **Clinical Significance:** The clinical significance of SNORD35A is not fully understood, but its expression in various cell types suggests that it may be involved in the development of various diseases, including: 1. **Autoimmune disorders:** SNORD35A may play a role in regulating the expression of immune-related genes in plasma cells, which could contribute to the development of autoimmune disorders. 2. **Cancer:** SNORD35A may be involved in regulating the expression of genes involved in cellular proliferation and differentiation, which could contribute to the development of cancer. 3. **Neurological disorders:** SNORD35A may play a role in regulating the expression of genes involved in neuronal function, which could contribute to the development of neurological disorders. In conclusion, SNORD35A is a non-coding RNA molecule that plays a crucial role in regulating RNA processing, nucleolus formation, and immune regulation. Further research is needed to fully understand its functions and clinical significance, but its expression in various cell types suggests that it may be involved in the development of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.