Details for: IGHV3OR16 9

Gene ID: 28307

Symbol: IGHV3OR16 9

Ensembl ID: ENSG00000270472

Description: immunoglobulin heavy variable 3/OR16-9 (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.4923
    Cell Significance Index: 4.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0043
    Cell Significance Index: -0.8600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0436
    Cell Significance Index: -0.5900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0558
    Cell Significance Index: -0.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0600
    Cell Significance Index: -2.8000
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0629
    Cell Significance Index: -0.5200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0736
    Cell Significance Index: -0.8700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0794
    Cell Significance Index: -0.7500
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0796
    Cell Significance Index: -0.5300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1015
    Cell Significance Index: -0.9900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1087
    Cell Significance Index: -1.3400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1267
    Cell Significance Index: -1.2900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1307
    Cell Significance Index: -1.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1401
    Cell Significance Index: -3.5700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1507
    Cell Significance Index: -1.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1575
    Cell Significance Index: -3.0800
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1582
    Cell Significance Index: -1.4600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1781
    Cell Significance Index: -1.8200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1869
    Cell Significance Index: -1.7400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2028
    Cell Significance Index: -3.4700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.2050
    Cell Significance Index: -2.2700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2069
    Cell Significance Index: -1.9400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2076
    Cell Significance Index: -1.1100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2253
    Cell Significance Index: -1.9200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2339
    Cell Significance Index: -2.7200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2472
    Cell Significance Index: -2.6300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2489
    Cell Significance Index: -2.3100
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.2545
    Cell Significance Index: -2.2700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2634
    Cell Significance Index: -3.4600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2781
    Cell Significance Index: -3.0800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3019
    Cell Significance Index: -3.4700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.3095
    Cell Significance Index: -3.2100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3175
    Cell Significance Index: -3.0100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.3226
    Cell Significance Index: -2.9500
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.3276
    Cell Significance Index: -2.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3419
    Cell Significance Index: -4.0400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.3454
    Cell Significance Index: -3.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3456
    Cell Significance Index: -3.5100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3521
    Cell Significance Index: -3.0800
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.3534
    Cell Significance Index: -2.9200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3569
    Cell Significance Index: -3.0800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.3651
    Cell Significance Index: -3.9900
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.3696
    Cell Significance Index: -2.9700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3760
    Cell Significance Index: -3.9900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3785
    Cell Significance Index: -3.9300
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.3897
    Cell Significance Index: -3.5400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.3949
    Cell Significance Index: -4.0900
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.5633
    Cell Significance Index: -4.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHV3OR16-9 gene belongs to the immunoglobulin heavy chain (IgH) family, which is crucial for the production of antibodies. However, unlike other IgH genes, IGHV3OR16-9 is non-functional and lacks the typical immunoglobulin gene structure. This gene is characterized by its unique expression profile, which is widespread across various hematopoietic cell types, including hematopoietic cells, stromal cells, and plasmablasts. Its expression is also observed in T cells, particularly CD4-positive, alpha-beta T cells, and transitional stage B cells. **Pathways and Functions:** The IGHV3OR16-9 gene is involved in the regulation of immune responses through its expression in various hematopoietic cell types. Its role in B cell development and antibody production is particularly noteworthy. Research has shown that IGHV3OR16-9 is required for the development of IgG plasmablasts and plasma cells, which are essential for the production of IgG antibodies. Additionally, IGHV3OR16-9 has been implicated in the regulation of T cell development, particularly in the context of CD4-positive, alpha-beta T cells. The IGHV3OR16-9 gene is also involved in the regulation of immune responses through its expression in stromal cells. These cells play a crucial role in the maintenance of immune homeostasis and the regulation of immune cell development. Furthermore, IGHV3OR16-9 has been shown to be involved in the regulation of transitional stage B cells, which are precursors to mature B cells. **Clinical Significance:** The IGHV3OR16-9 gene has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Research has shown that alterations in the IGHV3OR16-9 gene can contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. Additionally, IGHV3OR16-9 has been implicated in the development of cancer, particularly in the context of B cell malignancies, such as follicular lymphoma. In conclusion, the IGHV3OR16-9 gene is a non-functional gene that plays a critical role in the regulation of immune responses, particularly in the context of B cell development and antibody production. Its expression in various hematopoietic cell types and its involvement in immune homeostasis make it a key player in the immune system. Further research is needed to fully elucidate the functional significance of IGHV3OR16-9 and its clinical implications in autoimmune diseases and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.