Details for: LINC00174

Gene ID: 285908

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC00174

Ensembl ID: ENSG00000179406

Description: long intergenic non-protein coding RNA 174

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • ciliated epithelial cell CL0000067
    CSI 6.56
    rCSI 5.77%
    PRS 87.22
  • pulmonary alveolar type 2 cell CL0002063
    CSI 4.66
    rCSI 7.23%
    PRS 94.42
  • renal interstitial pericyte CL1001318
    CSI 4.36
    rCSI 12.02%
    PRS 92.7
  • melanocyte CL0000148
    CSI 3.75
    rCSI 2.78%
    PRS 91.8
  • interneuron CL0000099
    CSI 3.71
    rCSI 7.45%
    PRS 89.78
  • brush cell of tracheobronchial tree CL0002075
    CSI 3.62
    rCSI 10.75%
    PRS 97.41
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 3.12
    rCSI 4.42%
    PRS 92.75
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.95
    rCSI 3.67%
    PRS 82.66
  • cerebellar granule cell CL0001031
    CSI 2.89
    rCSI 4.25%
    PRS 90.23
  • lung neuroendocrine cell CL1000223
    CSI 2.79
    rCSI 4.13%
    PRS 94.66
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.78
    rCSI 7.24%
    PRS 95.41
  • cerebral cortex endothelial cell CL1001602
    CSI 2.68
    rCSI 4.63%
    PRS 90.46
  • adipocyte CL0000136
    CSI 2.67
    rCSI 3.43%
    PRS 87.6
  • choroid plexus epithelial cell CL0000706
    CSI 2.59
    rCSI 4.24%
    PRS 88.97
  • glioblast CL0000030
    CSI 2.56
    rCSI 4.08%
    PRS 88.11
  • Mueller cell CL0000636
    CSI 2.52
    rCSI 5.76%
    PRS 89.13
  • lung ciliated cell CL1000271
    CSI 2.48
    rCSI 2.87%
    PRS 89.87
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 2.4
    rCSI 6.2%
    PRS 92.39
  • cardiac muscle cell CL0000746
    CSI 2.03
    rCSI 2.91%
    PRS 87.7
  • Bergmann glial cell CL0000644
    CSI 2.02
    rCSI 2.76%
    PRS 88.37
  • alveolar adventitial fibroblast CL4028006
    CSI 1.99
    rCSI 3.15%
    PRS 94.91
  • Schwann cell CL0002573
    CSI 1.99
    rCSI 5.65%
    PRS 91.22
  • epithelial cell of proximal tubule CL0002306
    CSI 1.96
    rCSI 4.78%
    PRS 89.13
  • alveolar macrophage CL0000583
    CSI 1.91
    rCSI 3.15%
    PRS 95.32
  • macroglial cell CL0000126
    CSI 1.77
    rCSI 4.55%
    PRS 90.83
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.66
    rCSI 3.73%
    PRS 84.96
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.59
    rCSI 16.85%
    PRS 91.08
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.59
    rCSI 4.03%
    PRS 90.18
  • basal cell CL0000646
    CSI 1.55
    rCSI 2.07%
    PRS 91.67
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.52
    rCSI 5.47%
    PRS 83.02
  • parietal epithelial cell CL1000452
    CSI 1.36
    rCSI 3.62%
    PRS 90.44
  • retinal ganglion cell CL0000740
    CSI 1.27
    rCSI 2.8%
    PRS 86.19
  • mesothelial cell CL0000077
    CSI 1.15
    rCSI 4.5%
    PRS 81.94
  • GABAergic amacrine cell CL4030027
    CSI 1.06
    rCSI 3.63%
    PRS 83.88
  • direct pathway medium spiny neuron CL4023026
    CSI 0.9
    rCSI 21.54%
    PRS 82.52
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.88
    rCSI 21.27%
    PRS 82.42
  • pulmonary alveolar type 1 cell CL0002062
    CSI 0.79
    rCSI 4.57%
    PRS 91.96
  • ON parasol ganglion cell CL4033052
    CSI 0.51
    rCSI 7.19%
    PRS 87.9
  • ON midget ganglion cell CL4033046
    CSI 0.39
    rCSI 7.96%
    PRS 87.19
  • OFF midget ganglion cell CL4033047
    CSI 0.33
    rCSI 6.8%
    PRS 87.67

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC00174](/details-gene/285908) is a long intergenic non-coding RNA (lncRNA) located on chromosome 7. The gene's expression profile suggests it plays a significant role in a diverse array of specialized cell types across multiple organ systems. **Overall**, its expression is most prominent in [ciliated epithelial cells](/details-cell/CL0000067), [pulmonary alveolar type 2 cells](/details-cell/CL0002063), and [renal interstitial pericytes](/details-cell/CL1001318). This pattern indicates potential functions related to mucosal barrier integrity, cellular secretion, and micro-environmental regulation in tissues such as the lung, kidney, and brain. ## Cellular Roles and Expression Landscape The expression landscape of [LINC00174](/details-gene/285908) is characterized by high significance in functionally distinct and specialized cell populations rather than being restricted to a single lineage. * **Respiratory System:** The gene shows its highest significance in the respiratory epithelium, with top markers being [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 6.56) and [pulmonary alveolar type 2 cell](/details-cell/CL0002063) (CSI: 4.66). Its presence is also noted in [brush cells of the tracheobronchial tree](/details-cell/CL0002075) and [lung neuroendocrine cells](/details-cell/CL1000223). This strong association with multiple lung epithelial types suggests a role in maintaining airway function, possibly through regulating mucociliary clearance, surfactant production, or chemosensory processes. * **Renal System:** [LINC00174](/details-gene/285908) is a significant marker in key renal cells, including [renal interstitial pericytes](/details-cell/CL1001318) and [kidney loop of Henle thin descending limb epithelial cells](/details-cell/CL1001111). This expression pattern points towards a potential involvement in regulating renal microcirculation, fibrosis, and the maintenance of osmotic gradients essential for water reabsorption. * **Nervous System and Other Tissues:** The gene is also notably expressed in various neuronal and secretory cells, such as [interneurons](/details-cell/CL0000099), [melanocytes](/details-cell/CL0000148), and [choroid plexus epithelial cells](/details-cell/CL0000706). This diverse expression profile suggests that [LINC00174](/details-gene/285908) may be involved in fundamental cellular processes that are leveraged by different specialized cell types, from neurotransmission to pigment production and cerebrospinal fluid regulation. ## Pathways and Molecular Function Based on the available data, specific GO or Reactome pathway annotations for [LINC00174](/details-gene/285908) are not provided. However, its cell-specific expression patterns allow for functional inference. Its high significance in secretory and barrier-forming epithelial cells (e.g., [pulmonary alveolar type 2 cell](/details-cell/CL0002063), [choroid plexus epithelial cell](/details-cell/CL0000706)) suggests it may act as a transcriptional or post-transcriptional regulator of pathways involved in protein and lipid secretion, ion transport, or the maintenance of cellular polarity and tight junctions. As a lncRNA, it could function by scaffolding protein complexes, acting as a competing endogenous RNA (ceRNA) to sequester microRNAs, or by directly modulating chromatin structure at target gene loci. ## Research Directions The diverse and highly specific expression pattern of [LINC00174](/details-gene/285908) presents several avenues for future investigation. Its role as a potential regulator in distinct physiological systems warrants further study, particularly in the context of disease. **Proposed Hypotheses:** 1. Given its high expression in [ciliated epithelial cells](/details-cell/CL0000067) and [pulmonary alveolar type 2 cells](/details-cell/CL0002063), [LINC00174](/details-gene/285908) may be a critical regulator of lung homeostasis, modulating gene expression programs related to ciliary function, surfactant protein synthesis, or the inflammatory response to inhaled pathogens or particulates. 2. The significant expression in [renal interstitial pericytes](/details-cell/CL1001318), cells implicated in the development of kidney fibrosis, suggests that [LINC00174](/details-gene/285908) could be involved in the pericyte-to-myofibroblast transition and may be dysregulated during chronic kidney disease. **Key Experimental Approach:** To test the hypothesis regarding its role in lung homeostasis (Hypothesis 1), a targeted knockdown of [LINC00174](/details-gene/285908) could be performed in primary human bronchial epithelial cells cultured in an air-liquid interface (ALI) model. The impact of the knockdown could be assessed by measuring changes in ciliary beat frequency via high-speed video microscopy, evaluating barrier integrity through transepithelial electrical resistance (TEER), and quantifying the expression of key functional genes (e.g., *FOXJ1*, *MUC5AC*, *SFTPC*) using qPCR and RNA-sequencing. **Therapeutic Potential:** As a lncRNA, [LINC00174](/details-gene/285908) represents a non-traditional but increasingly viable class of therapeutic targets. Its high specificity in certain cell types makes it an attractive candidate for targeted therapies, potentially reducing off-target effects. If its dysregulation is linked to pathologies like idiopathic pulmonary fibrosis or chronic kidney disease, antisense oligonucleotides (ASOs) could be designed to inhibit its function. Conversely, if its loss contributes to disease, strategies to enhance its expression could be explored. Furthermore, its specific expression profile suggests potential utility as a diagnostic or prognostic biomarker in diseases affecting the lungs, kidneys, or central nervous system.