Details for: TRAV7

Gene ID: 28686

Symbol: TRAV7

Ensembl ID: ENSG00000211781

Description: T cell receptor alpha variable 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.0231
    Cell Significance Index: 0.2400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0187
    Cell Significance Index: 0.2700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0141
    Cell Significance Index: 0.0900
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.0137
    Cell Significance Index: 0.1200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0090
    Cell Significance Index: 0.1500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0087
    Cell Significance Index: 0.1100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0107
    Cell Significance Index: -0.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0115
    Cell Significance Index: -0.2200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0134
    Cell Significance Index: -0.1500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0143
    Cell Significance Index: -0.1700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0152
    Cell Significance Index: -0.1800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0162
    Cell Significance Index: -0.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0168
    Cell Significance Index: -0.1600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0170
    Cell Significance Index: -0.1800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0178
    Cell Significance Index: -0.2300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0190
    Cell Significance Index: -0.2200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0206
    Cell Significance Index: -0.2100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0213
    Cell Significance Index: -0.2200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0221
    Cell Significance Index: -0.2500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0226
    Cell Significance Index: -0.2300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0227
    Cell Significance Index: -0.1800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0237
    Cell Significance Index: -0.2400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0238
    Cell Significance Index: -0.2400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0246
    Cell Significance Index: -0.2200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0249
    Cell Significance Index: -0.2200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0249
    Cell Significance Index: -0.2300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0253
    Cell Significance Index: -0.2400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0255
    Cell Significance Index: -0.2200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0257
    Cell Significance Index: -0.2400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0259
    Cell Significance Index: -0.2400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0261
    Cell Significance Index: -0.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0265
    Cell Significance Index: -0.3100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0267
    Cell Significance Index: -0.2300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0276
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0289
    Cell Significance Index: -0.2800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0291
    Cell Significance Index: -0.4000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0303
    Cell Significance Index: -0.3300
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0337
    Cell Significance Index: -0.3300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0465
    Cell Significance Index: -0.3900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0627
    Cell Significance Index: -0.3400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0727
    Cell Significance Index: -0.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** TRAV7 is located on chromosome 7q33.3 and belongs to the TCR alpha variable region family. It is a single-copy gene, meaning it has only one copy in the human genome. 2. **Expression Patterns:** TRAV7 is expressed in a variety of cell types, including lymphoid lineage-restricted progenitor cells, goblet cells, hematopoietic stem cells, unswitched memory B cells, and neoplastic cells. This widespread expression suggests a critical role in immune development and function. 3. **Cell-Specific Expression:** The expression of TRAV7 varies across different cell types, with some cells expressing it exclusively, while others may co-express it with other TRAV genes. This cell-specific expression is essential for maintaining immune diversity and preventing autoimmune responses. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV7 is involved in the adaptive immune response, recognizing and responding to pathogens, including bacteria. It is a key component of the TCR complex, which interacts with major histocompatibility complex (MHC) molecules to initiate an immune response. 2. **TCR Complex Formation:** TRAV7 forms part of the TCR complex, which is composed of alpha, beta, gamma, delta, and epsilon chains. The interaction between TRAV7 and other TCR components enables the recognition of antigens and the activation of immune cells. 3. **Immune Homeostasis:** TRAV7 plays a crucial role in maintaining immune homeostasis by regulating the expression of other TCR genes and preventing autoimmune responses. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions in the TRAV7 gene can lead to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). This highlights the importance of TRAV7 in maintaining immune function. 2. **Cancer:** The expression of TRAV7 in neoplastic cells suggests its potential role in cancer development and progression. Further research is needed to understand the relationship between TRAV7 and cancer. 3. **Infectious Diseases:** TRAV7's involvement in the adaptive immune response makes it a potential target for the development of novel therapies against infectious diseases, such as bacterial infections. In conclusion, TRAV7 is a critical component of the adaptive immune system, playing a pivotal role in recognizing and responding to pathogens, including bacteria. Its widespread expression and cell-specific expression patterns highlight its importance in maintaining immune homeostasis and preventing autoimmune responses. Further research is needed to fully elucidate the role of TRAV7 in human disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.