Details for: TRAJ53

Gene ID: 28702

Symbol: TRAJ53

Ensembl ID: ENSG00000211837

Description: T cell receptor alpha joining 53

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0038
    Cell Significance Index: 0.0700
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0035
    Cell Significance Index: -0.0300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0036
    Cell Significance Index: -0.0500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0052
    Cell Significance Index: -0.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0061
    Cell Significance Index: -0.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0064
    Cell Significance Index: -0.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0071
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0084
    Cell Significance Index: -0.1600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0091
    Cell Significance Index: -0.1200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0099
    Cell Significance Index: -0.0900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0099
    Cell Significance Index: -0.1000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0104
    Cell Significance Index: -0.1000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0106
    Cell Significance Index: -0.1200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0107
    Cell Significance Index: -0.1000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0117
    Cell Significance Index: -0.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0124
    Cell Significance Index: -0.1500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0150
    Cell Significance Index: -0.1400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0150
    Cell Significance Index: -0.1900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0153
    Cell Significance Index: -0.1700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0154
    Cell Significance Index: -0.1800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0172
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0188
    Cell Significance Index: -0.1900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0213
    Cell Significance Index: -0.2200
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0222
    Cell Significance Index: -0.2000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0226
    Cell Significance Index: -0.2000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0229
    Cell Significance Index: -0.2000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0245
    Cell Significance Index: -0.1900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0247
    Cell Significance Index: -0.2000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0251
    Cell Significance Index: -0.2200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0276
    Cell Significance Index: -0.2400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0278
    Cell Significance Index: -0.2200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0328
    Cell Significance Index: -0.1800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0536
    Cell Significance Index: -0.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRAJ53, also known as T cell receptor alpha joining 53, is a gene that encodes a protein involved in the development and maturation of T cells, a type of immune cell. The gene is highly expressed in various immune cells, including CD8-positive alpha-beta T cells, double-positive alpha-beta thymocytes, and CD4-positive helper T cells. This widespread expression suggests that TRAJ53 plays a crucial role in the regulation of T cell development and function. Notably, TRAJ53 is also expressed in mature NK T cells, B cells, and effector memory CD8-positive alpha-beta T cells, highlighting its involvement in the broader immune response. **Pathways and Functions** TRAJ53 is integral to the T cell receptor (TCR) signaling pathway, which is essential for the activation and proliferation of T cells. The protein encoded by TRAJ53 interacts with the TCR alpha chain, facilitating the assembly and stabilization of the TCR complex. This interaction is crucial for the initiation of T cell activation, as it enables the TCR to recognize and bind to specific antigens. In addition to its role in TCR signaling, TRAJ53 is also involved in the regulation of T cell differentiation and survival. The protein has been shown to interact with other key signaling molecules, such as phospholipase C gamma 2 (PLCγ2) and protein kinase C (PKC), which are essential for the activation of T cells. Furthermore, TRAJ53 has been implicated in the regulation of T cell apoptosis, with studies suggesting that the protein plays a role in the inhibition of T cell death. **Clinical Significance** The clinical significance of TRAJ53 is an area of active research, with potential implications for the treatment of immune-related disorders. For example, studies have shown that TRAJ53 is overexpressed in certain types of cancer, such as leukemia and lymphoma, suggesting that the protein may play a role in the development and progression of these diseases. Additionally, TRAJ53 has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where aberrant T cell activation and differentiation contribute to disease pathogenesis. In conclusion, TRAJ53 is a gene that plays a critical role in the development and function of T cells, a type of immune cell. Its involvement in TCR signaling, differentiation, and survival pathways highlights its importance in immune system regulation. Further research is needed to fully elucidate the clinical significance of TRAJ53 and its potential applications in the treatment of immune-related disorders. **Future Directions** Future studies should aim to further elucidate the functional significance of TRAJ53 in immune cells. This may involve: 1. Investigating the role of TRAJ53 in T cell development and differentiation in the context of immune system regulation. 2. Examining the protein's interaction with other key signaling molecules and its impact on T cell activation and proliferation. 3. Exploring the clinical implications of TRAJ53 in immune-related disorders, such as cancer and autoimmune diseases. By advancing our understanding of TRAJ53, we may uncover new therapeutic strategies for the treatment of immune-related disorders and improve our ability to regulate the immune system.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.