Details for: MIR30B

Gene ID: 407030

Symbol: MIR30B

Ensembl ID: ENSG00000207582

Description: microRNA 30b

Associated with

  • Cellular response to bmp stimulus
    (GO:0071773)
  • Extracellular space
    (GO:0005615)
  • Extracellular vesicle
    (GO:1903561)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of dendritic spine maintenance
    (GO:1902951)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of execution phase of apoptosis
    (GO:1900118)
  • Negative regulation of long-term synaptic potentiation
    (GO:1900272)
  • Negative regulation of mini excitatory postsynaptic potential
    (GO:0061886)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of regulatory t cell differentiation
    (GO:0045590)
  • Negative regulation of vascular endothelial cell proliferation
    (GO:1905563)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of sprouting angiogenesis
    (GO:1903672)
  • Positive regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030511)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.3416
    Cell Significance Index: 3.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2666
    Cell Significance Index: 2.7600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0728
    Cell Significance Index: 1.0000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0575
    Cell Significance Index: 0.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0411
    Cell Significance Index: 0.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0387
    Cell Significance Index: 0.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0021
    Cell Significance Index: -0.0400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0067
    Cell Significance Index: -0.0700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0082
    Cell Significance Index: -0.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0086
    Cell Significance Index: -0.2300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0143
    Cell Significance Index: -0.1800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0191
    Cell Significance Index: -0.1700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0206
    Cell Significance Index: -0.2400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0217
    Cell Significance Index: -0.2600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0228
    Cell Significance Index: -0.2600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0229
    Cell Significance Index: -0.1800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0234
    Cell Significance Index: -0.2900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0256
    Cell Significance Index: -0.3200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0282
    Cell Significance Index: -0.3800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0298
    Cell Significance Index: -0.2500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0317
    Cell Significance Index: -0.4000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0322
    Cell Significance Index: -0.3800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0329
    Cell Significance Index: -0.4300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0346
    Cell Significance Index: -0.3800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0349
    Cell Significance Index: -0.4000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0364
    Cell Significance Index: -0.3900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0367
    Cell Significance Index: -0.4000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0377
    Cell Significance Index: -0.5400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0382
    Cell Significance Index: -0.4500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0414
    Cell Significance Index: -0.3800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0420
    Cell Significance Index: -0.3700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0435
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0498
    Cell Significance Index: -0.7200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0562
    Cell Significance Index: -0.3900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0611
    Cell Significance Index: -0.8100
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0755
    Cell Significance Index: -0.3600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0815
    Cell Significance Index: -0.9300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0844
    Cell Significance Index: -0.9800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1166
    Cell Significance Index: -1.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR30B exhibits a unique expression profile, with significantly elevated levels in certain cell types, such as retinal pigment epithelial cells and endothelial cells. Its expression is also modulated by various cellular stimuli, including BMP (Bone Morphogenetic Protein) signaling. MIR30B is a member of the microRNA family, characterized by its 22-nucleotide length and complementary binding sites to target messenger RNAs (mRNAs). Its regulatory activity is mediated through the destabilization of target mRNAs, leading to decreased protein expression. **Pathways and Functions:** MIR30B is implicated in various cellular processes, including: 1. **Cellular response to BMP stimulus:** MIR30B is activated by BMP signaling, leading to the regulation of downstream targets involved in cell proliferation, differentiation, and survival. 2. **Angiogenesis:** MIR30B negatively regulates angiogenesis by targeting pro-angiogenic factors, such as vascular endothelial growth factor (VEGF). 3. **Neurotransmission:** MIR30B modulates the expression of neurotransmitter receptors, influencing synaptic plasticity and neuronal communication. 4. **Immune response:** MIR30B regulates the differentiation and function of immune cells, including T cells and dendritic cells. 5. **Apoptosis:** MIR30B negatively regulates apoptosis by targeting pro-apoptotic factors, such as BAX and BAK. **Clinical Significance:** MIR30B dysregulation has been implicated in various diseases, including: 1. **Neurological disorders:** MIR30B expression alterations have been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer:** MIR30B is downregulated in various types of cancer, including lung, breast, and colon cancer. 3. **Cardiovascular disease:** MIR30B expression is altered in cardiovascular diseases, including atherosclerosis and hypertension. 4. **Immune-mediated disorders:** MIR30B dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, MIR30B is a complex gene with a wide range of regulatory activities, influencing various cellular processes and disease pathways. Further research is necessary to fully elucidate the mechanisms underlying MIR30B's functions and to explore its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.