Gene CENPVL2 - ENSG00000283093 | NCBI Gene ID: 441495

Details for: CENPVL2

Gene ID: 441495

Symbol: CENPVL2

Ensembl ID: ENSG00000283093

Description: centromere protein V like 2

Associated with

Carbon-sulfur lyase activity
(GO:0016846)
Metal ion binding
(GO:0046872)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 3.76
Marker Score: 1571
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 3.22
Marker Score: 1571
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2.97
Marker Score: 1565
Cell Name: erythrocyte (CL0000232)
Fold Change: 2.84
Marker Score: 1572
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 2.79
Marker Score: 1086
Cell Name: dendritic cell (CL0000451)
Fold Change: 2.27
Marker Score: 1559
Cell Name: T cell (CL0000084)
Fold Change: 1.91
Marker Score: 3288
Cell Name: mast cell (CL0000097)
Fold Change: 1.85
Marker Score: 1070
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.72
Marker Score: 2742
Cell Name: plasma cell (CL0000786)
Fold Change: 1.58
Marker Score: 1768.5
Cell Name: glial cell (CL0000125)
Fold Change: 1.43
Marker Score: 1573
Cell Name: regulatory T cell (CL0000815)
Fold Change: 1.42
Marker Score: 1573
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.32
Marker Score: 1183
Cell Name: B cell (CL0000236)
Fold Change: 1.28
Marker Score: 1219
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 1.28
Marker Score: 1018
Cell Name: fibroblast (CL0000057)
Fold Change: 1.25
Marker Score: 1205
Cell Name: basal cell (CL0000646)
Fold Change: 1.22
Marker Score: 1573
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.13
Marker Score: 1560
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.11
Marker Score: 1572
Cell Name: goblet cell (CL0000160)
Fold Change: 1.08
Marker Score: 7159
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.96
Marker Score: 29665
Cell Name: brush cell (CL0002204)
Fold Change: 0.94
Marker Score: 859
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.89
Marker Score: 2267
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.79
Marker Score: 4514
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.79
Marker Score: 2354
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.78
Marker Score: 4741
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.75
Marker Score: 1205
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.75
Marker Score: 1566
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.67
Marker Score: 1572
Cell Name: Unknown (CL0000003)
Fold Change: 0.51
Marker Score: 1573
Cell Name: neuron (CL0000540)
Fold Change: 0.39
Marker Score: 1571
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.26
Marker Score: 1361.5

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Other Information

Description

**Key Characteristics:** CENPVL2 is a protein-coding gene that belongs to the centromere protein V (CENP-V) family. The gene is characterized by its ability to bind metal ions, which is essential for its function. CENPVL2 is also involved in the regulation of cellular differentiation, particularly in the development of hematopoietic cells. Its expression is tightly regulated, and dysregulation of CENPVL2 has been implicated in various diseases, including cancer and autoimmune disorders. **Pathways and Functions:** CENPVL2 is involved in several key pathways that regulate cellular differentiation and immune responses. Its primary function is to bind metal ions, which is essential for its role in the regulation of cellular differentiation. CENPVL2 is also involved in the regulation of the carbon-sulfur lyase activity, which is a critical pathway in the metabolism of sulfur-containing amino acids. Additionally, CENPVL2 is a metal ion-binding protein, which is essential for its function in regulating cellular differentiation and immune responses. **Functions:** CENPVL2 has several functions that are critical for maintaining tissue homeostasis and immune homeostasis. Its primary function is to regulate cellular differentiation, particularly in the development of hematopoietic cells. CENPVL2 is also involved in the regulation of immune responses, particularly in the development of T cells and dendritic cells. Furthermore, CENPVL2 is a metal ion-binding protein, which is essential for its function in regulating cellular differentiation and immune responses. **Clinical Significance:** Dysregulation of CENPVL2 has been implicated in various diseases, including cancer and autoimmune disorders. For example, studies have shown that CENPVL2 is overexpressed in certain types of cancer, including leukemia and lymphoma. Additionally, CENPVL2 has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. Furthermore, CENPVL2 has been shown to be a potential target for immunotherapy, particularly in the treatment of cancer and autoimmune disorders. In conclusion, CENPVL2 is a gene that plays a critical role in regulating cellular differentiation and immune responses. Its dysregulation has been implicated in various diseases, and it is a potential target for immunotherapy. Further research is needed to fully understand the role of CENPVL2 in human disease and to explore its potential as a therapeutic target. **Recommendations:** 1. Further research is needed to fully understand the role of CENPVL2 in human disease. 2. CENPVL2 should be considered as a potential target for immunotherapy in the treatment of cancer and autoimmune disorders. 3. The expression and function of CENPVL2 should be studied in more detail to understand its role in regulating cellular differentiation and immune responses. **Limitations:** The current understanding of CENPVL2 is limited, and further research is needed to fully understand its role in human disease. Additionally, the expression and function of CENPVL2 are not well understood, and further research is needed to fully understand its role in regulating cellular differentiation and immune responses. **Future Directions:** Future research should focus on understanding the expression and function of CENPVL2 in more detail. Additionally, the development of specific therapies targeting CENPVL2 should be explored as a potential treatment for cancer and autoimmune disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.