Details for: ZNF595

Gene ID: 152687

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ZNF595

Ensembl ID: ENSG00000272602

Description: zinc finger protein 595

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • conventional dendritic cell CL0000990
    CSI 19.64
    rCSI 16.4%
    PRS 84.17
  • chondrocyte CL0000138
    CSI 3.71
    rCSI 5.9%
    PRS 83.15
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.54
    rCSI 4.4%
    PRS 71.69
  • melanocyte CL0000148
    CSI 3.52
    rCSI 2.61%
    PRS 83.86
  • cerebral cortex endothelial cell CL1001602
    CSI 3.51
    rCSI 6.08%
    PRS 82.17
  • VIP GABAergic cortical interneuron CL4023016
    CSI 3.41
    rCSI 4.08%
    PRS 74
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.61
    rCSI 16.29%
    PRS 81.41
  • vascular leptomeningeal cell CL4023051
    CSI 2.45
    rCSI 4.29%
    PRS 84.14
  • hepatic stellate cell CL0000632
    CSI 2.44
    rCSI 9.15%
    PRS 82.96
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.31
    rCSI 5.18%
    PRS 74.52
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.29
    rCSI 2.95%
    PRS 75.01
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.72
    rCSI 2.76%
    PRS 75.05
  • basal cell of epidermis CL0002187
    CSI 1.71
    rCSI 3.03%
    PRS 58.82
  • cardiac muscle cell CL0000746
    CSI 1.45
    rCSI 2.09%
    PRS 79.78
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.23
    rCSI 2.06%
    PRS 73.87
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.11
    rCSI 1.95%
    PRS 73.41
  • dopaminergic neuron CL0000700
    CSI 1.02
    rCSI 5.74%
    PRS 76.88
  • follicular B cell CL0000843
    CSI 1.01
    rCSI 3.67%
    PRS 95.85
  • germinal center B cell CL0000844
    CSI 1
    rCSI 2.99%
    PRS 93.16
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1
    rCSI 1.21%
    PRS 68.94
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.93
    rCSI 2.26%
    PRS 71.64
  • blood vessel smooth muscle cell CL0019018
    CSI 0.81
    rCSI 6.58%
    PRS 84.56
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.71
    rCSI 4.2%
    PRS 74.36
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.71
    rCSI 2.21%
    PRS 75.31
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.57
    rCSI 2.16%
    PRS 74.15
  • central nervous system neuron CL2000029
    CSI 0.53
    rCSI 3.92%
    PRS 78.62
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.53
    rCSI 1.65%
    PRS 77.25
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.51
    rCSI 1.82%
    PRS 71.87
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.24
    rCSI 5.71%
    PRS 71.94
  • direct pathway medium spiny neuron CL4023026
    CSI 0.22
    rCSI 5.21%
    PRS 71.52

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ZNF595](/details-gene/152687) is a protein-coding gene located on chromosome 4p16.3 that encodes a zinc finger protein. Functional annotations strongly indicate that [ZNF595](/details-gene/152687) acts as a DNA-binding transcription factor that specifically regulates gene expression via RNA polymerase II. Expression data reveals a highly distinct profile, with its significance overwhelmingly concentrated in [conventional dendritic cell](/details-cell/CL0000990), suggesting a critical role in the function of this immune cell type. Beyond this, it is expressed at more moderate levels across a diverse range of tissues, including various neuronal subtypes, [chondrocyte](/details-cell/CL0000138), and [melanocyte](/details-cell/CL0000148), pointing towards pleiotropic but context-specific regulatory functions. ## Cellular Roles and Expression Landscape The expression profile of [ZNF595](/details-gene/152687) is characterized by a uniquely high degree of cell-type specificity. **Overall**, the gene's significance is most pronounced in the immune system, where it stands out as a top marker for [conventional dendritic cell](/details-cell/CL0000990) with an exceptionally high Cell Significance Index (CSI) of 19.64. This score suggests that [ZNF595](/details-gene/152687) is not only highly expressed but its expression pattern is a defining feature of this cell type, likely making it a key regulator of its identity or function. Beyond the immune context, [ZNF595](/details-gene/152687) demonstrates a broader but less dominant role in other tissues. It shows moderate significance in structural cells such as [chondrocyte](/details-cell/CL0000138) (CSI: 3.71) and pigment-producing [melanocyte](/details-cell/CL0000148) (CSI: 3.52). Notably, the gene is also consistently expressed across several distinct subtypes of inhibitory neurons in the brain, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 3.54) and [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 3.41), indicating a potential role in regulating the function of cortical microcircuits. Its presence in cell types like [cerebral cortex endothelial cell](/details-cell/CL1001602) and [regular ventricular cardiac myocyte](/details-cell/CL0002131) further highlights its pleiotropic nature, albeit at levels significantly lower than observed in dendritic cells. ## Pathways and Molecular Function The functional annotations for [ZNF595](/details-gene/152687) align precisely with its predicted role as a nuclear protein involved in the regulation of gene expression. Gene Ontology (GO) terms confirm its localization to the [nucleus](/details-cell/GO:0005634) and its molecular function as a [DNA-binding transcription factor activity, rna polymerase ii-specific](/details-cell/GO:0000981) that recognizes [rna polymerase ii cis-regulatory region sequence-specific dna binding](/details-cell/GO:0000978). This is further supported by its annotation to the biological process of [regulation of transcription by rna polymerase ii](/details-cell/GO:0006357). Reactome pathway analysis reinforces this role, placing [ZNF595](/details-gene/152687) within fundamental transcriptional pathways, including [Gene expression (transcription)](https://reactome.org/content/detail/R-HSA-74160) and [Rna polymerase ii transcription](https://reactome.org/content/detail/R-HSA-73857). This molecular function is consistent with its observed expression pattern; its exceptionally high significance in [conventional dendritic cell](/details-cell/CL0000990) suggests it may act as a master regulator of transcriptional programs essential for antigen presentation and immune activation. In other cell types, such as cortical interneurons, it likely contributes to the fine-tuning of gene networks that define their specialized functions. ## Research Directions The highly specific expression pattern of [ZNF595](/details-gene/152687) in dendritic cells, combined with its established role as a transcription factor, presents compelling avenues for future research into immune regulation and neurology. ### Testable Hypotheses 1. Given its exceptionally high and specific expression in [conventional dendritic cell](/details-cell/CL0000990), [ZNF595](/details-gene/152687) functions as a master regulator essential for the maturation, antigen presentation capacity, and/or cytokine production of these cells. Its dysregulation could therefore impair adaptive immune responses, contributing to conditions like cancer immune evasion or autoimmunity. 2. The consistent expression of [ZNF595](/details-gene/152687) across multiple subtypes of cortical GABAergic interneurons suggests it plays a conserved role in establishing or maintaining the transcriptional programs that define the functional identity of these inhibitory neurons. Loss of [ZNF595](/details-gene/152687) function may disrupt the excitatory-inhibitory balance in the cerebral cortex. ### Proposed Experiment To test the primary hypothesis regarding its role in dendritic cells, a targeted knockout of [ZNF595](/details-gene/152687) in the mouse hematopoietic system would be highly informative. Bone marrow from conditional knockout mice (e.g., Zfp595-floxed crossed with CD11c-Cre) could be used to generate bone marrow-derived dendritic cells (BMDCs). These BMDCs, alongside wild-type controls, would be stimulated with an activating agent like LPS. The functional consequences of [ZNF595](/details-gene/152687) deletion could be assessed through RNA-sequencing to identify downstream target genes, flow cytometry to analyze the expression of co-stimulatory molecules (CD80, CD86), and functional co-culture assays (e.g., mixed lymphocyte reaction) to measure their ability to activate T cells. ### Therapeutic Potential As an intracellular transcription factor, [ZNF595](/details-gene/152687) is not an ideal target for conventional antibody-based therapies. However, its high specificity for [conventional dendritic cell](/details-cell/CL0000990) makes it an attractive candidate for modulating immune function. In oncology, strategies aimed at enhancing the activity or expression of [ZNF595](/details-gene/152687) could be explored to boost dendritic cell potency for cancer vaccines or immunotherapies. Conversely, in autoimmune diseases driven by overactive dendritic cells, targeted inhibition of [ZNF595](/details-gene/152687) function, potentially through siRNA-based therapeutics or novel small molecules, could represent a highly specific immunosuppressive strategy with fewer off-target effects.

Genular Protein ID: 2529202963

Symbol: ZN595_HUMAN

Name: Zinc finger protein 595

UniProtKB Accession Codes:

Q8IYB9 Q7Z3I0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 648
  • Mass: 74302
  • Checksum: EBCB193E1D4660E1
  • Sequence:
    • MELVTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLGFVISNP DLVTCLEQIK 
EPCNLKIHET AAKPPAICSP FSQDLSPVQG IEDSFHKLIL KRYEKCGHEN LQLRKGCKRV 
NECKVQKGVN NGVYQCLSTT QSKIFQCNTC VKVFSKFSNS NKHKIRHTGE KPFKCTECGR 
SFYMSHLTQH TGIHAGEKPY KCEKCGKAFN RSTSLSKHKR IHTGEKPYTC EECGKAFRRS 
TVLNEHKKIH TGEKPYKCEE CGKAFTRSTT LNEHKKIHTG EKPYKCKECG KAFRWSTSLN 
EHKNIHTGEK PYKCKECGKA FRQSRSLNEH KNIHTGEKPY TCEKCGKAFN QSSSLIIHRS 
IHSEQKLYKC EECGKAFTWS SSLNKHKRIH TGEKPYTCEE CGKAFYRSSH LAKHKRIHTG 
EKPYTCEECG KAFNQSSTLI LHKRIHSGQK PYKCEECGKA FTRSTTLNEH KKIHTGEKPY 
KCEECGKAFI WSASLNEHKN IHTGEKPYKC KECGKAFNQS SGLIIHRSIH SEQKLYKCEE 
CGKAFTRSTA LNEHKKIHSG EKPYKCKECG KAYNLSSTLT KHKRIHTGEK PFTCEECGKA 
FNWSSSLTKH KIIHTGEKSY KCEECGKAFN RPSTLTVHKR IHTGKEHS

Genular Protein ID: 1773132826

Symbol: B4DX79_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DX79

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 465
  • Mass: 53307
  • Checksum: 056F4BD0E07A43C1
  • Sequence:
    • MSHLTQHTGI HAGEKPYKCE KCGKAFNRST SLSKHKRIHT GEKPYTCEEC GKAFRRSTVL 
NEHKKIHTGE KPYKCEECGK AFTRSTTLNE HKKIHTGEKP YKCKECGKAF RWSTSLNEHK 
NIHTGEKPYK CKECGKAFRQ SRSLNEHKNI HTGEKPYTCE KCGKAFNQSS SLIIHRSIHS 
EQKLYKCEEC GKAFTWSSSL NKHKRIHTGE KPYTCEECGE AFYRSSHLAK HKRIHTGEKP 
YTCEECGKAF NQSSTLILHK RIHSGQKPYK CEECGKAFTR STTLNEHKKI HTGEKPYKCE 
ECGKAFIWSA SLNEHKNIHT GEKPYKCKEC GKAFNQSSGL IIHRSIHSEQ KLYKCEECGK 
AFTRSTALNE HKKIHSGEKP YKCKECGKAY NLSSTLTKHK RIHTGEKPFT CEECGKAFNW 
SSSLTKHKII HTGEKSYKCE ECGKAFNRPS TLTVHKRIHT GKEHS

Genular Protein ID: 1996208421

Symbol: A0A075B7G4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A075B7G4

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 616
  • Mass: 70814
  • Checksum: 93A3D0C7750398BF
  • Sequence:
    • MELVTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLAICSPFS QDLSPVQGIE 
DSFHKLILKR YEKCGHENLQ LRKGCKRVNE CKVQKGVNNG VYQCLSTTQS KIFQCNTCVK 
VFSKFSNSNK HKIRHTGEKP FKCTECGRSF YMSHLTQHTG IHAGEKPYKC EKCGKAFNRS 
TSLSKHKRIH TGEKPYTCEE CGKAFRRSTV LNEHKKIHTG EKPYKCEECG KAFTRSTTLN 
EHKKIHTGEK PYKCKECGKA FRWSTSLNEH KNIHTGEKPY KCKECGKAFR QSRSLNEHKN 
IHTGEKPYTC EKCGKAFNQS SSLIIHRSIH SEQKLYKCEE CGKAFTWSSS LNKHKRIHTG 
EKPYTCEECG KAFYRSSHLA KHKRIHTGEK PYTCEECGKA FNQSSTLILH KRIHSGQKPY 
KCEECGKAFT RSTTLNEHKK IHTGEKPYKC EECGKAFIWS ASLNEHKNIH TGEKPYKCKE 
CGKAFNQSSG LIIHRSIHSE QKLYKCEECG KAFTRSTALN EHKKIHSGEK PYKCKECGKA 
YNLSSTLTKH KRIHTGEKPF TCEECGKAFN WSSSLTKHKI IHTGEKSYKC EECGKAFNRP 
STLTVHKRIH TGKEHS

Genular Protein ID: 1415553822

Symbol: B4DU56_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DU56

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 Pfam 2 RefSeq 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 616
  • Mass: 70842
  • Checksum: FFF8157B2873F9EC
  • Sequence:
    • MELVTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLAICSPFS QDLSPVQGIE 
DSFHKLILKR YEKCGHENLQ LRKGCKRVNE CKVQKGVNNG VYQCLSTTQS KIFQCNTCVK 
VFSKFSNSNK HRIRHTGEKP FKCTECGRSF YMSHLTQHTG IHAGEKPYKC EKCGKAFNRS 
TSLSKHKRIH TGEKPYTCEE CGKAFRRSTV LNEHKKIHTG EKPYKCEECG KAFTRSTTLN 
EHKKIHTGEK PYKCKECGKA FRWSTSLNEH KNIHTGEKPY KCKECGKAFR QSRSLNEHKN 
IHTGEKPYTC EKCGKAFNQS SSLIIHRSIH SEQKLYKCEE CGKAFTWSSS LNKHKRIHTG 
EKPYTCEECG KAFYRSSHLA KHKRIHTGEK PYTCEECGKA FNQSSTLILH KRIHSGQKPY 
KCEECGKAFT RSTTLNEHKK IHTGEKPYKC EECGKAFIWS ASLNEHKNIH TGEKPYKCKE 
CGKAFNQSSG LIIHRSIHSE QKLYKCEECG KAFTRSTALN EHKKIHSGEK PYKCKECGKA 
YNLSSTLTKH KRIHTGEKPF TCEECGKAFN WSSSLTKHKI IHTGEKSYKC EECGKAFNRP 
STLTVHKRIH TGKEHS

Genular Protein ID: 1983371253

Symbol: A0A075B7G3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A075B7G3

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 465
  • Mass: 53306
  • Checksum: E5696BD0E078C96B
  • Sequence:
    • MSHLTQHTGI HAGEKPYKCE KCGKAFNRST SLSKHKRIHT GEKPYTCEEC GKAFRRSTVL 
NEHKKIHTGE KPYKCEECGK AFTRSTTLNE HKKIHTGEKP YKCKECGKAF RWSTSLNEHK 
NIHTGEKPYK CKECGKAFRQ SRSLNEHKNI HTGEKPYTCE KCGKAFNQSS SLIIHRSIHS 
EQKLYKCEEC GKAFTWSSSL NKHKRIHTGE KPYTCEECGK AFYRSSHLAK HKRIHTGEKP 
YTCEECGKAF NQSSTLILHK RIHSGQKPYK CEECGKAFTR STTLNEHKKI HTGEKPYKCE 
ECGKAFIWSA SLNEHKNIHT GEKPYKCKEC GKAFNQSSGL IIHRSIHSEQ KLYKCEECGK 
AFTRSTALNE HKKIHSGEKP YKCKECGKAY NLSSTLTKHK RIHTGEKPFT CEECGKAFNW 
SSSLTKHKII HTGEKSYKCE ECGKAFNRPS TLTVHKRIHT GKEHS