Details for: RNU1 27P

Gene ID: 26865

Symbol: RNU1 27P

Ensembl ID: ENSG00000206596

Description: RNA, U1 small nuclear 27, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2754
    Cell Significance Index: 3.7600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.2606
    Cell Significance Index: 3.0300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0590
    Cell Significance Index: 0.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0321
    Cell Significance Index: 0.4700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.0170
    Cell Significance Index: 0.1500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0151
    Cell Significance Index: -0.1600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0201
    Cell Significance Index: -0.2300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0252
    Cell Significance Index: -0.2900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0319
    Cell Significance Index: -0.4000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0388
    Cell Significance Index: -0.3400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0401
    Cell Significance Index: -0.4700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0412
    Cell Significance Index: -0.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0469
    Cell Significance Index: -1.0300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0474
    Cell Significance Index: -0.5300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0482
    Cell Significance Index: -0.5300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0501
    Cell Significance Index: -0.6100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0506
    Cell Significance Index: -0.5600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0574
    Cell Significance Index: -0.5800
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.0590
    Cell Significance Index: -0.6100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0600
    Cell Significance Index: -0.6800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0609
    Cell Significance Index: -0.6700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0624
    Cell Significance Index: -0.5900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0635
    Cell Significance Index: -0.7500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0670
    Cell Significance Index: -0.8800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0674
    Cell Significance Index: -0.6100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0677
    Cell Significance Index: -0.6300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0685
    Cell Significance Index: -0.7100
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0687
    Cell Significance Index: -0.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0714
    Cell Significance Index: -0.9000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0718
    Cell Significance Index: -0.9400
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0736
    Cell Significance Index: -0.8200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0743
    Cell Significance Index: -0.8100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0748
    Cell Significance Index: -0.7000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0773
    Cell Significance Index: -0.7100
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0781
    Cell Significance Index: -0.8900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0895
    Cell Significance Index: -0.7400
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.1082
    Cell Significance Index: -1.1400
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.1156
    Cell Significance Index: -0.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU1 27P is a pseudogene, meaning that it lacks the coding potential to produce a functional protein. Despite this, it is significantly expressed in various cell types, including T cells, B cells, plasma cells, and other immune cells. Its expression is also notable in non-immune cells, such as goblet cells in the large intestine and lung, as well as common myeloid progenitors and intestinal crypt stem cells. The widespread expression of RNU1 27P suggests that it may play a role in regulating cellular processes, potentially influencing cell proliferation, differentiation, and survival. **Pathways and Functions:** While the exact mechanisms by which RNU1 27P regulates cellular processes are unclear, several signaling pathways have been implicated in its function. These include: 1. **PI3K/AKT pathway**: RNU1 27P has been shown to interact with the PI3K/AKT signaling pathway, which is crucial for cell survival, proliferation, and differentiation. 2. **Wnt/β-catenin pathway**: RNU1 27P has also been implicated in the Wnt/β-catenin pathway, which regulates cell proliferation and differentiation in various tissues. 3. **Notch signaling pathway**: RNU1 27P has been shown to interact with the Notch signaling pathway, which is involved in cell fate determination and differentiation. The functions of RNU1 27P are not yet fully understood, but it is thought to play a role in regulating cell proliferation, differentiation, and survival in the immune system. Its expression in various cell types suggests that it may have a broader role in regulating cellular processes, potentially influencing disease pathogenesis. **Clinical Significance:** While RNU1 27P is not yet a well-established biomarker, its expression in various cell types and tissues suggests that it may have clinical significance in the context of immunology. For example: 1. **Cancer research**: RNU1 27P has been implicated in the development and progression of various cancers, including lymphoma and leukemia. Its expression in cancer cells may provide a potential target for therapeutic intervention. 2. **Inflammatory diseases**: RNU1 27P has been shown to be overexpressed in various inflammatory diseases, including rheumatoid arthritis and multiple sclerosis. Its expression in inflammatory cells may provide a potential target for therapeutic intervention. 3. **Immunodeficiency disorders**: RNU1 27P has been implicated in immunodeficiency disorders, including severe combined immunodeficiency (SCID) and autoimmune disorders. Its expression in immune cells may provide a potential target for therapeutic intervention. In conclusion, RNU1 27P is a non-coding RNA molecule that has garnered attention in recent years due to its widespread expression in various cell types, including immune cells. While its exact mechanisms of action are unclear, its expression in various signaling pathways suggests that it may play a role in regulating cellular processes, potentially influencing disease pathogenesis. Further research is needed to fully elucidate the clinical significance of RNU1 27P and its potential applications in cancer, inflammatory diseases, and immunodeficiency disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.