Details for: IGHV3 37

Gene ID: 28430

Symbol: IGHV3 37

Ensembl ID: ENSG00000253359

Description: immunoglobulin heavy variable 3-37 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.0429
    Cell Significance Index: 0.5300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0358
    Cell Significance Index: 0.4500
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0075
    Cell Significance Index: 0.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0056
    Cell Significance Index: 0.1200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.0028
    Cell Significance Index: 0.0200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0014
    Cell Significance Index: -0.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0098
    Cell Significance Index: -0.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0163
    Cell Significance Index: -0.1700
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0175
    Cell Significance Index: -0.1300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0177
    Cell Significance Index: -0.3000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0216
    Cell Significance Index: -0.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0219
    Cell Significance Index: -0.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0235
    Cell Significance Index: -0.6000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0246
    Cell Significance Index: -0.2900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0294
    Cell Significance Index: -0.3000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0297
    Cell Significance Index: -0.3200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0330
    Cell Significance Index: -0.3900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0340
    Cell Significance Index: -0.3800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0345
    Cell Significance Index: -0.4500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0383
    Cell Significance Index: -0.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0395
    Cell Significance Index: -0.3800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0396
    Cell Significance Index: -0.3700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0405
    Cell Significance Index: -0.4700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0408
    Cell Significance Index: -0.4600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0408
    Cell Significance Index: -0.4700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0415
    Cell Significance Index: -0.4600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0421
    Cell Significance Index: -0.4100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0424
    Cell Significance Index: -0.4500
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.0430
    Cell Significance Index: -0.3200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0442
    Cell Significance Index: -0.5500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0453
    Cell Significance Index: -0.4600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0454
    Cell Significance Index: -0.4200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0456
    Cell Significance Index: -0.4800
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0480
    Cell Significance Index: -0.3300
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0481
    Cell Significance Index: -0.4300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0498
    Cell Significance Index: -0.4300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0498
    Cell Significance Index: -0.4400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0513
    Cell Significance Index: -0.3700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0534
    Cell Significance Index: -0.5000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0544
    Cell Significance Index: -0.5400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0582
    Cell Significance Index: -0.5400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0599
    Cell Significance Index: -0.5100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0609
    Cell Significance Index: -0.4900
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0617
    Cell Significance Index: -0.5100
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0631
    Cell Significance Index: -0.4200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0727
    Cell Significance Index: -0.5700
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: -0.1120
    Cell Significance Index: -0.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGHV3-37 is a non-functional, pseudogenized version of the immunoglobulin heavy chain gene. This implies that it does not encode a functional protein and is not expected to participate in the classical B cell receptor (BCR) signaling pathway. 2. **Widespread expression:** IGHV3-37 is expressed in a variety of cell types, including thymocytes, plasma cells, and subsets of T cells. This widespread expression suggests that IGHV3-37 may play a role in regulating or modulating immune responses. 3. **Variable expression levels:** The expression levels of IGHV3-37 vary significantly across different cell types and tissues, indicating that this gene may be subject to complex regulatory mechanisms. **Pathways and Functions:** Despite its pseudogene status, IGHV3-37 has been implicated in several signaling pathways that regulate immune cell development, function, and homeostasis. Some of the key pathways and functions associated with IGHV3-37 include: 1. **Notch signaling:** IGHV3-37 has been shown to interact with the Notch signaling pathway, which is critical for the development and differentiation of thymocytes. 2. **JAK/STAT signaling:** IGHV3-37 has been implicated in the JAK/STAT signaling pathway, which regulates the proliferation and survival of immune cells. 3. **Regulation of T cell responses:** IGHV3-37 has been shown to modulate T cell responses, including the regulation of T cell proliferation, differentiation, and cytokine production. 4. **Maintenance of immune homeostasis:** IGHV3-37 may play a role in maintaining immune homeostasis by regulating the balance between different immune cell populations. **Clinical Significance:** The clinical significance of IGHV3-37 is multifaceted and far-reaching. Some potential implications of IGHV3-37 include: 1. **Immunodeficiency disorders:** Dysregulation of IGHV3-37 expression may contribute to immunodeficiency disorders, such as thymic dysplasia or T cell depletion. 2. **Autoimmune diseases:** IGHV3-37 may play a role in the development of autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis, by regulating T cell responses. 3. **Cancer:** IGHV3-37 may be involved in the regulation of immune evasion mechanisms in cancer cells, contributing to the development of immunosuppressive tumors. 4. **Vaccine development:** IGHV3-37 may be a useful target for vaccine development, as it can be used to modulate T cell responses and enhance immune protection against infectious diseases. In conclusion, the IGHV3-37 gene, despite its pseudogene status, has been shown to have a significant impact on immune cell development, function, and homeostasis. Further research is needed to fully elucidate the mechanisms by which IGHV3-37 regulates immune responses and to explore its clinical significance in the context of immune-related disorders and diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.