Details for: TRAJ17

Gene ID: 28738

Symbol: TRAJ17

Ensembl ID: ENSG00000211872

Description: T cell receptor alpha joining 17

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.1639
    Cell Significance Index: 1.3700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0169
    Cell Significance Index: 0.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0006
    Cell Significance Index: -0.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0019
    Cell Significance Index: -0.3800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0044
    Cell Significance Index: -0.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0079
    Cell Significance Index: -0.4400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0084
    Cell Significance Index: -0.1100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0183
    Cell Significance Index: -0.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0185
    Cell Significance Index: -0.2200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0278
    Cell Significance Index: -0.3700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0282
    Cell Significance Index: -0.3000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0321
    Cell Significance Index: -0.3600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0322
    Cell Significance Index: -0.3800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0325
    Cell Significance Index: -0.4200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0328
    Cell Significance Index: -0.3800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0332
    Cell Significance Index: -0.4100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0337
    Cell Significance Index: -0.3900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0339
    Cell Significance Index: -0.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0344
    Cell Significance Index: -0.4600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0349
    Cell Significance Index: -0.4600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0352
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0356
    Cell Significance Index: -0.3600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0377
    Cell Significance Index: -0.3800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0382
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0384
    Cell Significance Index: -0.3900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0387
    Cell Significance Index: -0.4100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0394
    Cell Significance Index: -0.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0395
    Cell Significance Index: -0.3800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0400
    Cell Significance Index: -0.4300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0401
    Cell Significance Index: -0.3800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0410
    Cell Significance Index: -0.4000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0410
    Cell Significance Index: -0.4200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0411
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0417
    Cell Significance Index: -0.3900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0431
    Cell Significance Index: -0.3700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0440
    Cell Significance Index: -0.3800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0446
    Cell Significance Index: -0.3900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0486
    Cell Significance Index: -0.4100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0514
    Cell Significance Index: -0.4000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0538
    Cell Significance Index: -0.3700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0544
    Cell Significance Index: -0.4400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0556
    Cell Significance Index: -0.5000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0568
    Cell Significance Index: -0.4900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0697
    Cell Significance Index: -0.3800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1181
    Cell Significance Index: -0.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRAJ17 is significantly expressed in various immune cells, including naive thymus-derived CD4-positive and CD8-positive T cells, as well as exhausted T cells. 2. **Cell Type Specificity:** The expression of TRAJ17 is cell-type specific, indicating its involvement in the development and function of specific T cell subsets. 3. **Gene Function:** The function of TRAJ17 is not well understood, but it is likely involved in the regulation of T cell development, differentiation, and function. 4. **Evolutionary Conservation:** The conservation of TRAJ17 across different species suggests its evolutionary importance and suggests that it may play a conserved role in the immune system. **Pathways and Functions:** 1. **T Cell Receptor Signaling:** TRAJ17 may play a role in the regulation of T cell receptor signaling, which is essential for the activation and function of T cells. 2. **T Cell Development:** TRAJ17 may be involved in the development of T cells in the thymus, where T cells undergo positive and negative selection to become functional T cells. 3. **T Cell Differentiation:** TRAJ17 may also play a role in the differentiation of T cells into specific subsets, such as CD4-positive and CD8-positive T cells. 4. **Immune Cell Regulation:** TRAJ17 may also regulate the function of other immune cells, such as natural killer cells and dendritic cells, which interact with T cells to regulate the immune response. **Clinical Significance:** 1. **Cancer Immunotherapy:** Understanding the function of TRAJ17 may provide insights into the development of cancer immunotherapies, which aim to harness the power of the immune system to fight cancer. 2. **Autoimmune Diseases:** TRAJ17 may also play a role in the regulation of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where T cells play a central role in the disease process. 3. **Infectious Diseases:** TRAJ17 may also be involved in the regulation of the immune response to infectious diseases, such as HIV and tuberculosis, where T cells play a critical role in controlling the infection. 4. **Regenerative Medicine:** TRAJ17 may also have implications for regenerative medicine, where the use of T cells to repair damaged tissues may be improved by understanding the function of TRAJ17. In conclusion, TRAJ17 is a complex gene that plays a crucial role in the development and function of T cells, a type of white blood cell that plays a central role in the adaptive immune response. Further research is needed to fully understand the function of TRAJ17 and its implications for human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.