Details for: IGKJ2

Gene ID: 28949

Symbol: IGKJ2

Ensembl ID: ENSG00000211596

Description: immunoglobulin kappa joining 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 9.9728
    Cell Significance Index: 254.0900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.8902
    Cell Significance Index: 66.5000
  • Cell Name: mast cell (CL0000097)
    Fold Change: 3.1648
    Cell Significance Index: 41.6500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.8415
    Cell Significance Index: 38.9700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.7953
    Cell Significance Index: 36.1700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.6005
    Cell Significance Index: 17.0000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2394
    Cell Significance Index: 3.4800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1225
    Cell Significance Index: 1.6100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.0815
    Cell Significance Index: 0.8600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.0516
    Cell Significance Index: 0.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0019
    Cell Significance Index: -0.0500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0191
    Cell Significance Index: -0.2300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0220
    Cell Significance Index: -0.2800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0258
    Cell Significance Index: -0.3000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0330
    Cell Significance Index: -0.3100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0339
    Cell Significance Index: -0.4400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0357
    Cell Significance Index: -0.4200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0357
    Cell Significance Index: -0.3200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0365
    Cell Significance Index: -0.3200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0367
    Cell Significance Index: -0.3700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0387
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0427
    Cell Significance Index: -0.4000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0501
    Cell Significance Index: -0.5600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0512
    Cell Significance Index: -0.8300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0548
    Cell Significance Index: -0.3500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0561
    Cell Significance Index: -0.4600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0656
    Cell Significance Index: -0.4100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0669
    Cell Significance Index: -0.7900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0756
    Cell Significance Index: -1.0100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0827
    Cell Significance Index: -0.8800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0843
    Cell Significance Index: -1.1000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1194
    Cell Significance Index: -1.1300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1842
    Cell Significance Index: -0.8500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1924
    Cell Significance Index: -4.8100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2259
    Cell Significance Index: -2.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4138
    Cell Significance Index: -4.7000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4167
    Cell Significance Index: -4.9200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.7584
    Cell Significance Index: -7.1900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.7629
    Cell Significance Index: -4.1600
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.7852
    Cell Significance Index: -7.1800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.8304
    Cell Significance Index: -8.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8535
    Cell Significance Index: -15.7700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.8982
    Cell Significance Index: -10.1200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.9012
    Cell Significance Index: -9.9800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -1.0587
    Cell Significance Index: -7.0500
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -1.3535
    Cell Significance Index: -10.3900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -2.0569
    Cell Significance Index: -22.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGKJ2 is a member of the immunoglobulin kappa joining complex, which consists of three genes: IGKJ1, IGKJ2, and IGKJ3. These genes encode the kappa joining domains that are essential for the assembly of the IgK molecule. IGKJ2 is characterized by its high expression levels in various cell types, particularly in hematopoietic stem cells, precursor B cells, and plasma cells. The gene is also expressed in other cell types, such as erythrocytes, double-negative thymocytes, and mast cells. **Pathways and Functions** The IGKJ2 gene plays a critical role in the development and maturation of B cells. The IgK molecule, which is assembled from the IGKJ2 gene, is essential for the humoral immune response. The IgK molecule recognizes and binds to specific antigens, triggering the activation of B cells and the production of antibodies. The IGKJ2 gene is also involved in the regulation of B cell development and differentiation. Studies have shown that the IGKJ2 gene is required for the proper assembly and functioning of the IgK molecule, which is essential for the development of B cells. **Clinical Significance** Dysregulation of the IGKJ2 gene has been implicated in various immune disorders, including autoimmune diseases and immunodeficiency disorders. For example, mutations in the IGKJ2 gene have been associated with X-linked agammaglobulinemia, a rare genetic disorder characterized by the absence of B cells and a lack of antibody production. Additionally, the IGKJ2 gene has been shown to be involved in the regulation of the humoral immune response in patients with autoimmune diseases, such as rheumatoid arthritis and lupus. In conclusion, the IGKJ2 gene plays a critical role in the development and maturation of B cells and the assembly of the IgK molecule. Its dysregulation has been implicated in various immune disorders, highlighting the importance of this gene in maintaining immune homeostasis. Further research is needed to fully understand the role of the IGKJ2 gene in the immune system and to develop therapeutic strategies for the treatment of immune-related disorders. **Recommendations for Future Research** 1. Further studies are needed to understand the mechanisms by which the IGKJ2 gene regulates B cell development and differentiation. 2. The role of the IGKJ2 gene in the regulation of the humoral immune response in autoimmune diseases needs to be further investigated. 3. The development of therapeutic strategies targeting the IGKJ2 gene may provide new approaches for the treatment of immune-related disorders. **References** [Insert references cited in the article] Note: The references provided are fictional and not actual references. In a real article, you would include actual references cited in the discussion.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.