Details for: IFNA16

Gene ID: 3449

Symbol: IFNA16

Ensembl ID: ENSG00000147885

Description: interferon alpha 16

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.31
    Marker Score: 3495.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.91
    Marker Score: 2630.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.58
    Marker Score: 899
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.15
    Marker Score: 608
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1
    Marker Score: 416
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 354
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 192.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1
    Marker Score: 208
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.08
    Marker Score: 152.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.05
    Marker Score: 741
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 97.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.04
    Marker Score: 252.5
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.03
    Marker Score: 203
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.02
    Marker Score: 5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.02
    Marker Score: 5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 6

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Other Information

**Key characteristics:** - IFNA16 is a protein of the interferon alpha family. - It is a secreted protein that is produced and released by cells. - It is expressed in high levels in response to infection or injury. - It has a molecular weight of approximately 160 kDa. **Pathways and functions:** - IFNA16 is a key regulator of the innate immune response. - It is involved in the induction of type I interferons, which are important for the control of viral infection. - It also plays a role in the regulation of cell survival and proliferation. - It has been shown to have a role in the regulation of inflammation. **Clinical significance:** - Mutations in IFNA16 have been linked to the development of several chronic diseases, including rheumatoid arthritis, lupus, and cancer. - Targeting IFNA16 has been explored as a therapeutic strategy for these diseases. **Additional information:** - IFNA16 is a protein that is highly conserved across species. - It is a member of the interferon alpha family of proteins, which are important for the regulation of innate immune responses. - It is a key regulator of the innate immune response and plays a role in the control of viral infection.

Genular Protein ID: 2006213260

Symbol: IFN16_HUMAN

Name: Interferon alpha-16

UniProtKB Accession Codes:

P05015 Q5VV12

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 6387705

Title: Human genomic library screened with 17-base oligonucleotide probes yields a novel interferon gene.

PubMed ID: 6387705

DOI: 10.1073/pnas.81.20.6451

PubMed ID: 6548765

Title: Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes.

PubMed ID: 6548765

DOI: 10.1089/jir.1984.4.609

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

Sequence Information:

  • Length: 189
  • Mass: 21711
  • Checksum: FC8822F787F1585F
  • Sequence:
    • MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF SCLKDRYDFG 
FPQEVFDGNQ FQKAQAISAF HEMIQQTFNL FSTKDSSAAW DETLLDKFYI ELFQQLNDLE 
ACVTQEVGVE EIALMNEDSI LAVRKYFQRI TLYLMGKKYS PCAWEVVRAE IMRSFSFSTN 
LQKGLRRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.