Details for: IFNA16

Gene ID: 3449

Symbol: IFNA16

Ensembl ID: ENSG00000147885

Description: interferon alpha 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.0179
    Cell Significance Index: 178.8000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.5475
    Cell Significance Index: 41.2600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.1723
    Cell Significance Index: 15.1700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.8455
    Cell Significance Index: 8.9800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4524
    Cell Significance Index: 6.2000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1988
    Cell Significance Index: 3.4000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.1085
    Cell Significance Index: 0.6400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0181
    Cell Significance Index: 0.2600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0024
    Cell Significance Index: 0.0200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0034
    Cell Significance Index: -0.0300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0064
    Cell Significance Index: -0.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0153
    Cell Significance Index: -4.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0503
    Cell Significance Index: -10.0900
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0647
    Cell Significance Index: -0.6400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0709
    Cell Significance Index: -0.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0826
    Cell Significance Index: -1.5300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0892
    Cell Significance Index: -1.1300
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0940
    Cell Significance Index: -0.8800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0972
    Cell Significance Index: -1.2900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1037
    Cell Significance Index: -0.9700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1294
    Cell Significance Index: -1.5900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1386
    Cell Significance Index: -1.6400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1456
    Cell Significance Index: -1.9100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1602
    Cell Significance Index: -1.6600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1615
    Cell Significance Index: -1.6500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1626
    Cell Significance Index: -1.5400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1653
    Cell Significance Index: -1.4600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1713
    Cell Significance Index: -1.9600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3287
    Cell Significance Index: -3.8600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3348
    Cell Significance Index: -6.6800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3511
    Cell Significance Index: -4.6200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4030
    Cell Significance Index: -4.8200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4200
    Cell Significance Index: -4.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4239
    Cell Significance Index: -6.0700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.4728
    Cell Significance Index: -6.1700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.5662
    Cell Significance Index: -6.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5766
    Cell Significance Index: -13.8300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7996
    Cell Significance Index: -10.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8448
    Cell Significance Index: -17.9300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.8666
    Cell Significance Index: -11.6900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.8982
    Cell Significance Index: -9.6300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.9252
    Cell Significance Index: -10.0800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -1.3184
    Cell Significance Index: -9.1400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.4716
    Cell Significance Index: -18.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.5166
    Cell Significance Index: -18.8100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.5704
    Cell Significance Index: -19.8200
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.7829
    Cell Significance Index: -16.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** IFNA16 consists of 165 amino acids, with a relatively low molecular weight (18 kDa) and a high degree of homology with other interferon-alpha proteins. 2. **Expression:** IFNA16 is primarily expressed in hematopoietic cells, including megakaryocytes, erythrocytes, and precursor B cells, as well as in certain immune cells such as mast cells and natural killer cells. 3. **Function:** IFNA16 exerts its effects by binding to the interferon-alpha/beta receptor, triggering a signaling cascade that leads to the production of antiviral proteins and the activation of immune cells. **Pathways and Functions:** 1. **Interferon Signaling Pathway:** IFNA16 binds to the interferon-alpha/beta receptor, triggering the activation of JAK/STAT signaling pathways, which ultimately lead to the transcription of interferon-stimulated genes (ISGs) involved in antiviral defense. 2. **Viral Defense:** IFNA16 plays a crucial role in the innate immune response against viral infections, particularly against respiratory syncytial virus (RSV), SARS-CoV-2, and other RNA viruses. 3. **Immune Cell Activation:** IFNA16 activates immune cells, including natural killer cells and mast cells, which are essential for the elimination of infected cells and the control of viral replication. 4. **Cytokine Signaling:** IFNA16 modulates the activity of various cytokines, including TNF-alpha, IL-6, and IL-1beta, which are involved in the regulation of immune responses and inflammation. **Clinical Significance:** 1. **Viral Infections:** IFNA16 plays a critical role in the defense against viral infections, particularly in the early stages of infection when the innate immune response is activated. 2. **Autoimmune Diseases:** Dysregulation of IFNA16 signaling has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** IFNA16 has been shown to have anti-tumor effects, inhibiting the growth and proliferation of cancer cells. 4. **Immunodeficiency:** Mutations in the IFNA16 gene have been associated with impaired immune function, increasing the susceptibility to infections and autoimmune diseases. In conclusion, IFNA16 is a crucial component of the innate immune response, playing a vital role in the defense against viral infections and the regulation of immune cell activation. Its dysregulation has been implicated in various physiological and pathological processes, highlighting the importance of further research into the mechanisms of IFNA16 signaling and its clinical applications.

Genular Protein ID: 2006213260

Symbol: IFN16_HUMAN

Name: Interferon alpha-16

UniProtKB Accession Codes:

P05015 Q5VV12

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 6387705

Title: Human genomic library screened with 17-base oligonucleotide probes yields a novel interferon gene.

PubMed ID: 6387705

DOI: 10.1073/pnas.81.20.6451

PubMed ID: 6548765

Title: Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes.

PubMed ID: 6548765

DOI: 10.1089/jir.1984.4.609

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

Sequence Information:

  • Length: 189
  • Mass: 21711
  • Checksum: FC8822F787F1585F
  • Sequence:
    • MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF SCLKDRYDFG 
FPQEVFDGNQ FQKAQAISAF HEMIQQTFNL FSTKDSSAAW DETLLDKFYI ELFQQLNDLE 
ACVTQEVGVE EIALMNEDSI LAVRKYFQRI TLYLMGKKYS PCAWEVVRAE IMRSFSFSTN 
LQKGLRRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.