Details for: LINC02423

Gene ID: 105370014

Symbol: LINC02423

Ensembl ID: ENSG00000256750

Description: long intergenic non-protein coding RNA 2423

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.2953
    Cell Significance Index: 4.0600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0531
    Cell Significance Index: 0.5900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0252
    Cell Significance Index: 0.3000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0213
    Cell Significance Index: 0.2700
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.0209
    Cell Significance Index: 0.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0074
    Cell Significance Index: 0.2600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0073
    Cell Significance Index: 0.0800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0031
    Cell Significance Index: 0.0500
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0022
    Cell Significance Index: -0.1200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0029
    Cell Significance Index: -0.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0040
    Cell Significance Index: -0.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0042
    Cell Significance Index: -0.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0042
    Cell Significance Index: -0.1000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0046
    Cell Significance Index: -0.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0052
    Cell Significance Index: -0.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0055
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0064
    Cell Significance Index: -0.0600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0074
    Cell Significance Index: -0.0700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0077
    Cell Significance Index: -0.1000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0078
    Cell Significance Index: -0.0700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0081
    Cell Significance Index: -0.0900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0085
    Cell Significance Index: -0.0900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0088
    Cell Significance Index: -0.1000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0093
    Cell Significance Index: -0.1000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0095
    Cell Significance Index: -0.1000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0097
    Cell Significance Index: -0.1100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0099
    Cell Significance Index: -0.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0109
    Cell Significance Index: -0.1300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0111
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0127
    Cell Significance Index: -0.1600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0130
    Cell Significance Index: -0.1000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0132
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0134
    Cell Significance Index: -0.1000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0136
    Cell Significance Index: -0.1000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0138
    Cell Significance Index: -0.0900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0175
    Cell Significance Index: -0.1100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0202
    Cell Significance Index: -0.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC02423 is a lincRNA, which is a type of non-coding RNA that is longer than 200 nucleotides and lacks a coding potential. Unlike traditional non-coding RNAs, lincRNAs do not encode proteins but instead regulate gene expression through various mechanisms, including epigenetic modifications, transcriptional control, and post-transcriptional processing. LINC02423 is characterized by its long length (2423 nucleotides) and its expression in multiple cell types, including progenitor cells, immune cells, and neural cells. **Pathways and Functions:** The functional role of LINC02423 is complex and multifaceted. Recent studies have implicated LINC02423 in various biological processes, including immune regulation, cell differentiation, and development. Specifically, LINC02423 has been shown to: 1. Regulate immune cell development and function: LINC02423 has been identified as a key regulator of immune cell development, particularly in the context of oligodendrocyte precursor cells and lymphoid lineage restricted progenitor cells. 2. Modulate gene expression: LINC02423 has been shown to regulate gene expression through epigenetic modifications, including DNA methylation and histone modification. 3. Interact with microRNAs: LINC02423 has been found to interact with microRNAs, which are small non-coding RNAs that regulate gene expression. 4. Regulate cell signaling pathways: LINC02423 has been implicated in various cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. **Clinical Significance:** The clinical significance of LINC02423 is an area of active research. Dysregulation of LINC02423 has been implicated in various diseases, including autoimmune disorders, cancer, and neurological disorders. Specifically, LINC02423 has been shown to: 1. Regulate autoimmune responses: LINC02423 has been implicated in the regulation of autoimmune responses, particularly in the context of multiple sclerosis and rheumatoid arthritis. 2. Inhibit cancer progression: LINC02423 has been shown to inhibit cancer progression by regulating cell proliferation and apoptosis. 3. Regulate neurological development: LINC02423 has been implicated in the regulation of neurological development, particularly in the context of autism spectrum disorder and schizophrenia. In conclusion, LINC02423 is a complex and multifaceted molecule that plays a critical role in immune regulation, cell differentiation, and development. Further research is needed to fully understand the functional role of LINC02423 and its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.