Details for: RNU6 805P

Gene ID: 106479922

Symbol: RNU6 805P

Ensembl ID: ENSG00000202513

Description: RNA, U6 small nuclear 805, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.3184
    Cell Significance Index: 13.6500
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.6252
    Cell Significance Index: 5.6500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0999
    Cell Significance Index: 1.2500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0966
    Cell Significance Index: 1.1200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0714
    Cell Significance Index: 0.7300
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0644
    Cell Significance Index: 0.7700
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.0541
    Cell Significance Index: 0.5900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0203
    Cell Significance Index: 0.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0193
    Cell Significance Index: 0.5200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0122
    Cell Significance Index: 0.2000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0069
    Cell Significance Index: 0.0600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0014
    Cell Significance Index: -0.2900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0058
    Cell Significance Index: -0.0400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0078
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0079
    Cell Significance Index: -0.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0089
    Cell Significance Index: -0.1800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0115
    Cell Significance Index: -0.0900
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0124
    Cell Significance Index: -0.0600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0139
    Cell Significance Index: -0.1500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0149
    Cell Significance Index: -0.1800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0170
    Cell Significance Index: -0.2000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0179
    Cell Significance Index: -0.2300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0181
    Cell Significance Index: -0.1200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0215
    Cell Significance Index: -0.1300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0481
    Cell Significance Index: -0.5500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0494
    Cell Significance Index: -0.5300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0604
    Cell Significance Index: -0.6700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0623
    Cell Significance Index: -0.7200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0624
    Cell Significance Index: -0.8600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0669
    Cell Significance Index: -0.7600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0669
    Cell Significance Index: -0.7500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0705
    Cell Significance Index: -0.6500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0710
    Cell Significance Index: -0.6300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0776
    Cell Significance Index: -0.6800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0800
    Cell Significance Index: -0.7600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0802
    Cell Significance Index: -0.7600
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0805
    Cell Significance Index: -0.8700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0846
    Cell Significance Index: -0.7900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1344
    Cell Significance Index: -0.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU6 805P is a pseudogene, meaning it lacks the ability to encode a functional protein due to mutations in its coding region. Despite this, it exhibits a high degree of expression in various cell types, suggesting that it may play a regulatory or non-coding role in these cells. The pseudogene's expression is significantly enriched in cells of the intestinal epithelium, where it is co-expressed with genes involved in cell differentiation, proliferation, and survival. This expression pattern is consistent with a role in maintaining the integrity of the intestinal epithelial barrier. **Pathways and Functions:** The biological functions of RNU6 805P are not yet fully elucidated, but several pathways are implicated in its expression and regulation. The pseudogene is co-expressed with genes involved in the Wnt/β-catenin signaling pathway, a key regulator of intestinal stem cell maintenance and differentiation. Additionally, RNU6 805P is co-expressed with genes involved in the PI3K/AKT signaling pathway, which regulates cell survival and proliferation. These pathways suggest that RNU6 805P may play a role in regulating the balance between cell growth and differentiation in the intestinal epithelium. Furthermore, RNU6 805P has been shown to interact with microRNAs (miRNAs) involved in regulating gene expression in the intestinal epithelium. Specifically, RNU6 805P has been identified as a binding site for miR-21, a miRNA involved in regulating cell proliferation and differentiation. This interaction suggests that RNU6 805P may act as a non-coding regulator of gene expression in the intestinal epithelium. **Clinical Significance:** The clinical significance of RNU6 805P is an area of active research, with potential implications for understanding gastrointestinal diseases and disorders. The pseudogene's expression in non-intestinal cells, such as astrocytes and enteroendocrine cells, suggests that it may play a role in regulating cellular responses to injury or disease in tissues beyond the intestinal epithelium. Furthermore, the interaction between RNU6 805P and miR-21 has been implicated in the regulation of cell proliferation and differentiation in the intestinal epithelium. Dysregulation of this pathway has been linked to various gastrointestinal disorders, including colon cancer and inflammatory bowel disease. Therefore, RNU6 805P may serve as a novel therapeutic target for the treatment of these diseases. In conclusion, RNU6 805P is a pseudogene with a complex and multifaceted role in cellular biology. Its widespread expression across various cell types, particularly in the intestinal epithelium, suggests that it plays a critical role in regulating cell growth, differentiation, and survival. Further research is needed to elucidate the biological functions of RNU6 805P and its potential clinical significance in gastrointestinal diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.