Details for: OR10H2

Gene ID: 26538

Symbol: OR10H2

Ensembl ID: ENSG00000171942

Description: olfactory receptor family 10 subfamily H member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0997
    Cell Significance Index: 1.0900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0555
    Cell Significance Index: 0.6400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0543
    Cell Significance Index: 0.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0366
    Cell Significance Index: 0.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0059
    Cell Significance Index: -1.0600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0105
    Cell Significance Index: -0.1300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0105
    Cell Significance Index: -0.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0161
    Cell Significance Index: -0.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0166
    Cell Significance Index: -0.7500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0202
    Cell Significance Index: -0.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0356
    Cell Significance Index: -0.5100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0356
    Cell Significance Index: -0.3500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0362
    Cell Significance Index: -0.5000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0380
    Cell Significance Index: -0.4100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0446
    Cell Significance Index: -0.5400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0447
    Cell Significance Index: -1.1400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0459
    Cell Significance Index: -0.5600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0546
    Cell Significance Index: -0.6500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0558
    Cell Significance Index: -0.6600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0561
    Cell Significance Index: -0.9700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0572
    Cell Significance Index: -0.6800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0594
    Cell Significance Index: -0.7500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0596
    Cell Significance Index: -0.7100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0605
    Cell Significance Index: -1.0300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0621
    Cell Significance Index: -0.5800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0630
    Cell Significance Index: -0.6600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0666
    Cell Significance Index: -0.7900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0669
    Cell Significance Index: -0.7100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0696
    Cell Significance Index: -1.1300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0763
    Cell Significance Index: -0.9400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0773
    Cell Significance Index: -0.7200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0778
    Cell Significance Index: -0.7700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0794
    Cell Significance Index: -1.0500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0829
    Cell Significance Index: -1.0700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0862
    Cell Significance Index: -0.8100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0882
    Cell Significance Index: -1.1600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0980
    Cell Significance Index: -1.3600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1071
    Cell Significance Index: -1.1600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1101
    Cell Significance Index: -1.1700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1123
    Cell Significance Index: -1.1900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1155
    Cell Significance Index: -1.1800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1310
    Cell Significance Index: -1.1500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1468
    Cell Significance Index: -1.0200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1542
    Cell Significance Index: -1.2700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1562
    Cell Significance Index: -1.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR10H2 is a member of the olfactory receptor family, which is responsible for detecting odorant molecules in the air we breathe. These receptors are expressed in the olfactory epithelium and play a crucial role in our sense of smell. 2. **Tissue-Specific Expression:** OR10H2 is significantly expressed in various cell types, including cardiac endothelial cells, pericytes, and fibroblasts of cardiac tissue. This suggests that OR10H2 may have a role in cardiovascular health and disease. 3. **G Protein-Coupled Receptor Activity:** OR10H2 is a G protein-coupled receptor, which means it can interact with G proteins to activate downstream signaling pathways. This activity is essential for the detection of chemical stimuli and the regulation of cellular responses. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR10H2 detects chemical stimuli involved in the sensory perception of smell. This detection is mediated by the binding of odorant molecules to the receptor, which activates G protein-coupled signaling pathways. 2. **G Protein-Coupled Receptor Signaling Pathway:** OR10H2 activates the G protein-coupled receptor signaling pathway, which is involved in various cellular responses, including the regulation of gene expression, cell proliferation, and differentiation. 3. **Olfactory Signaling Pathway:** OR10H2 is also involved in the olfactory signaling pathway, which is responsible for transmitting sensory information from the olfactory epithelium to the brain. **Clinical Significance:** 1. **Cardiovascular Disease:** OR10H2's expression in cardiac endothelial cells and fibroblasts of cardiac tissue suggests that it may play a role in cardiovascular health and disease. Dysregulation of OR10H2 could contribute to the development of cardiovascular disorders, such as hypertension and atherosclerosis. 2. **Immune-Related Disorders:** OR10H2's expression in immature innate lymphoid cells and lymphoid lineage-restricted progenitor cells suggests that it may also play a role in immune-related disorders, such as asthma and allergic rhinitis. 3. **Neurological Disorders:** OR10H2's expression in neuronal receptor cells suggests that it may also play a role in neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, OR10H2 is a multifunctional gene that plays a crucial role in detecting chemical stimuli involved in the sensory perception of smell. Its unique expression pattern and tissue-specific localization suggest that it may have a broader functional scope beyond the traditional olfactory system. Further research is needed to fully elucidate the function of OR10H2 and its clinical significance in various diseases.

Genular Protein ID: 1860018898

Symbol: O10H2_HUMAN

Name: Olfactory receptor 10H2

UniProtKB Accession Codes:

O60403 Q6IFQ1 Q96R58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

PubMed ID: 23647072

Title: Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.

PubMed ID: 23647072

DOI: 10.1111/epi.12201

Sequence Information:

  • Length: 315
  • Mass: 34663
  • Checksum: C68387742D3B9382
  • Sequence:
    • MLGLNHTSMS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHTPMY 
LFLCVLSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ MFFSFSFGFT HSFLLTVMGY 
DRYVAICHPL RYNVLMSPRG CACLVGCSWA GGSVMGMVVT SAIFQLTFCG SHEIQHFLCH 
VPPLLKLACG NNVPAVALGV GLVCIMALLG CFLLILLSYA FIVADILKIP SAEGRNKAFS 
TCASHLIVVI VHYGFASVIY LKPKGPHSQE GDTLMATTYA VLTPFLSPII FSLRNKELKV 
AMKRTFLSTL YSSGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.