Details for: RNU1 3

Gene ID: 26869

Symbol: RNU1 3

Ensembl ID: ENSG00000207513

Description: RNA, U1 small nuclear 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.0261
    Cell Significance Index: 0.2300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.0072
    Cell Significance Index: 0.1400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0092
    Cell Significance Index: -0.1600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0172
    Cell Significance Index: -0.1600
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0182
    Cell Significance Index: -0.1900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0201
    Cell Significance Index: -0.2200
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0217
    Cell Significance Index: -0.1900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0236
    Cell Significance Index: -0.2200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0243
    Cell Significance Index: -0.2800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0261
    Cell Significance Index: -0.3200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0262
    Cell Significance Index: -0.2900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0267
    Cell Significance Index: -0.3300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0280
    Cell Significance Index: -0.3100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0287
    Cell Significance Index: -0.3800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0288
    Cell Significance Index: -0.3400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0296
    Cell Significance Index: -0.3400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0304
    Cell Significance Index: -0.3400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0309
    Cell Significance Index: -0.3400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0311
    Cell Significance Index: -0.3000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0312
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0312
    Cell Significance Index: -0.3000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0328
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0331
    Cell Significance Index: -0.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0370
    Cell Significance Index: -0.3800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0378
    Cell Significance Index: -0.4100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0383
    Cell Significance Index: -0.5000
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0396
    Cell Significance Index: -0.3600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0403
    Cell Significance Index: -0.3700
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0407
    Cell Significance Index: -0.4500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0411
    Cell Significance Index: -0.3400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0428
    Cell Significance Index: -0.5200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0432
    Cell Significance Index: -0.4700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0460
    Cell Significance Index: -0.4100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0479
    Cell Significance Index: -0.4000
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.0514
    Cell Significance Index: -0.5300
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0538
    Cell Significance Index: -0.4400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0570
    Cell Significance Index: -0.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** RNU1 is significantly expressed in various cell types, including adventitial cells, goblet cells in the large intestine, intestinal tuft cells, T cells, transitional stage B cells, innate lymphoid cells, mature NK T cells, plasma cells, B cells, and CD4-positive, alpha-beta memory T cells. 2. **RNA, U1 Small Nuclear Complex:** RNU1 is a component of the RNA, U1 small nuclear complex, which plays a critical role in pre-mRNA processing and splicing. 3. **Conserved Sequence:** RNU1 exhibits a highly conserved sequence across different species, suggesting its essential role in cellular function. **Pathways and Functions:** 1. **Immune Regulation:** RNU1's expression in immune cells suggests its involvement in immune regulation, potentially influencing T cell and B cell activation, proliferation, and differentiation. 2. **RNA Processing:** As a component of the RNA, U1 small nuclear complex, RNU1 is involved in pre-mRNA processing and splicing, which is essential for the generation of mature mRNA for protein synthesis. 3. **Cell Signaling:** RNU1 may also participate in cell signaling pathways, influencing cellular responses to external stimuli, such as cytokines and growth factors. 4. **Epigenetic Regulation:** RNU1 may play a role in epigenetic regulation, influencing gene expression through mechanisms such as DNA methylation and histone modification. **Clinical Significance:** 1. **Immunological Disorders:** Dysregulation of RNU1 expression has been implicated in various immunological disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** Aberrant RNU1 expression has been observed in certain types of cancer, including lymphoma and leukemia, suggesting its potential role in tumorigenesis. 3. **Infectious Diseases:** RNU1's expression in innate lymphoid cells and mature NK T cells suggests its involvement in the defense against viral and bacterial infections. 4. **Neurological Disorders:** RNU1's expression in the brain and spinal cord suggests its potential role in neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, RNU1 is a multifunctional gene with significant implications for immune regulation, RNA processing, cell signaling, and epigenetic regulation. Further research is necessary to fully elucidate the role of RNU1 in human health and disease, and to explore its potential as a therapeutic target for various immunological and neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.