Details for: IGHV7 27

Gene ID: 28383

Symbol: IGHV7 27

Ensembl ID: ENSG00000254326

Description: immunoglobulin heavy variable 7-27 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.2130
    Cell Significance Index: 2.9000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0251
    Cell Significance Index: -0.2800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0263
    Cell Significance Index: -0.1800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0297
    Cell Significance Index: -0.3800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0366
    Cell Significance Index: -0.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0397
    Cell Significance Index: -1.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0402
    Cell Significance Index: -1.0300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0557
    Cell Significance Index: -0.6600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0575
    Cell Significance Index: -0.5200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0662
    Cell Significance Index: -0.7900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0746
    Cell Significance Index: -0.9600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0749
    Cell Significance Index: -0.8900
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0764
    Cell Significance Index: -0.8100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0780
    Cell Significance Index: -1.0000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0788
    Cell Significance Index: -0.8500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0807
    Cell Significance Index: -0.8500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0807
    Cell Significance Index: -0.9500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0827
    Cell Significance Index: -0.8800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0847
    Cell Significance Index: -0.9400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0867
    Cell Significance Index: -0.8100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0915
    Cell Significance Index: -0.7800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0927
    Cell Significance Index: -0.8600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0951
    Cell Significance Index: -0.9000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0960
    Cell Significance Index: -0.6300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0962
    Cell Significance Index: -0.9000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0978
    Cell Significance Index: -0.8400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0984
    Cell Significance Index: -0.9200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0995
    Cell Significance Index: -1.0700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0998
    Cell Significance Index: -1.1500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1000
    Cell Significance Index: -1.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1033
    Cell Significance Index: -0.9900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1038
    Cell Significance Index: -0.8800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1056
    Cell Significance Index: -1.1200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1093
    Cell Significance Index: -0.9400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1107
    Cell Significance Index: -1.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1190
    Cell Significance Index: -1.2600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1208
    Cell Significance Index: -1.1500
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1213
    Cell Significance Index: -0.9700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1242
    Cell Significance Index: -1.4700
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1325
    Cell Significance Index: -1.1700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1338
    Cell Significance Index: -1.5500
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1343
    Cell Significance Index: -1.1700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1363
    Cell Significance Index: -1.6600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1421
    Cell Significance Index: -1.4500
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.1503
    Cell Significance Index: -1.3900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1505
    Cell Significance Index: -1.2700
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1861
    Cell Significance Index: -1.3100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2238
    Cell Significance Index: -1.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV7-27 is a member of the immunoglobulin heavy chain variable region family and is characterized by a unique sequence that differs from other immunoglobulin genes. Notably, IGHV7-27 is a pseudogene, meaning that it is a non-functional gene that lacks the ability to encode a functional heavy chain variable region. Despite this, IGHV7-27 is significantly expressed in a wide range of immune cells, including thymocytes, B cells, and plasma cells. **Pathways and Functions:** The expression of IGHV7-27 in immune cells suggests that it may play a role in regulating immune responses. One possible function of IGHV7-27 is to modulate the activity of immune cells, such as B cells and T cells. The pseudogene may interact with other immune-related genes to influence the expression of cytokines, chemokines, and other immune-related proteins. In addition to its potential regulatory functions, IGHV7-27 may also be involved in the development and maturation of immune cells. The expression of IGHV7-27 in thymocytes and double-negative thymocytes suggests that it may play a role in the selection and development of T cells. **Clinical Significance:** The expression of IGHV7-27 in various immune cells has significant clinical implications. For example, the pseudogene has been found to be expressed in patients with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. This suggests that IGHV7-27 may play a role in the pathogenesis of these diseases, and that its expression may be used as a biomarker for disease diagnosis and prognosis. Furthermore, IGHV7-27 has been found to be expressed in plasma cells, which are involved in the production of antibodies. The expression of IGHV7-27 in plasma cells may influence the production of antibodies and the development of immune responses. In conclusion, the IGHV7-27 gene is a pseudogene that exhibits significant expression in various immune cells. Its potential role in regulating immune responses and modulating the activity of immune cells makes it an important gene for further study. The clinical significance of IGHV7-27 is also significant, particularly in the context of autoimmune diseases and antibody production. **Future Directions:** Further research is needed to fully understand the function and clinical significance of IGHV7-27. Future studies should focus on the mechanisms by which IGHV7-27 regulates immune responses and modulates the activity of immune cells. Additionally, the expression of IGHV7-27 in different disease contexts should be investigated to determine its role in the pathogenesis of autoimmune diseases and other immune-related disorders. In conclusion, the IGHV7-27 gene is a pseudogene that exhibits significant expression in various immune cells. Its potential role in regulating immune responses and modulating the activity of immune cells makes it an important gene for further study. The clinical significance of IGHV7-27 is also significant, particularly in the context of autoimmune diseases and antibody production.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.