Details for: IGHV3 36

Gene ID: 28431

Symbol: IGHV3 36

Ensembl ID: ENSG00000253240

Description: immunoglobulin heavy variable 3-36 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0522
    Cell Significance Index: 0.5300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.0274
    Cell Significance Index: 0.4700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0264
    Cell Significance Index: 0.2600
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.0079
    Cell Significance Index: 0.0600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0054
    Cell Significance Index: 0.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0047
    Cell Significance Index: -0.0400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0060
    Cell Significance Index: -0.0300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0086
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0109
    Cell Significance Index: -0.1000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0266
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0302
    Cell Significance Index: -0.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0302
    Cell Significance Index: -0.7700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0358
    Cell Significance Index: -0.4000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0368
    Cell Significance Index: -0.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0370
    Cell Significance Index: -0.4400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0387
    Cell Significance Index: -0.4100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0421
    Cell Significance Index: -0.5300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0427
    Cell Significance Index: -0.4000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0449
    Cell Significance Index: -0.4200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0454
    Cell Significance Index: -0.5200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0467
    Cell Significance Index: -0.4800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0491
    Cell Significance Index: -0.5800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0494
    Cell Significance Index: -0.5600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0509
    Cell Significance Index: -0.6000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0535
    Cell Significance Index: -0.5400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0538
    Cell Significance Index: -0.5500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0538
    Cell Significance Index: -0.5100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0545
    Cell Significance Index: -0.5800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0545
    Cell Significance Index: -0.4600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0556
    Cell Significance Index: -0.5200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0570
    Cell Significance Index: -0.6300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0576
    Cell Significance Index: -0.5200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0607
    Cell Significance Index: -0.7000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0621
    Cell Significance Index: -0.6500
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0631
    Cell Significance Index: -0.4200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0636
    Cell Significance Index: -0.6600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0657
    Cell Significance Index: -0.6600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0672
    Cell Significance Index: -0.5800
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0683
    Cell Significance Index: -0.4700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0704
    Cell Significance Index: -0.6000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0739
    Cell Significance Index: -0.7400
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0751
    Cell Significance Index: -0.7700
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0754
    Cell Significance Index: -0.7000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0761
    Cell Significance Index: -0.6700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0835
    Cell Significance Index: -0.7100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0877
    Cell Significance Index: -0.6500
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.0939
    Cell Significance Index: -0.8400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1350
    Cell Significance Index: -0.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogenic status:** IGHV3-36 is a non-functional gene due to mutations that prevent it from producing a viable immunoglobulin protein. 2. **Widespread expression:** IGHV3-36 is expressed in various cell types, including B cells, plasma cells, T cells, and innate lymphoid cells. 3. **Variable expression levels:** The expression levels of IGHV3-36 can vary significantly between different cell types and tissues. 4. **Cell type specificity:** IGHV3-36 is expressed in cells that are involved in different aspects of the immune response, including B cell development, T cell development, and innate immunity. **Pathways and Functions:** 1. **Regulation of immune responses:** IGHV3-36 may play a role in regulating immune responses by modulating the activity of immune cells or influencing the expression of other immune-related genes. 2. **Cellular differentiation:** IGHV3-36 may be involved in the regulation of cellular differentiation, particularly in the development of B cells and T cells. 3. **Innate immunity:** IGHV3-36 is expressed in innate lymphoid cells, suggesting that it may play a role in the regulation of innate immune responses. 4. **Immunological tolerance:** IGHV3-36 may be involved in the maintenance of immunological tolerance by regulating the activity of immune cells or influencing the expression of other immune-related genes. **Clinical Significance:** 1. **Immunodeficiency disorders:** The expression of IGHV3-36 in B cells and plasma cells suggests that it may be involved in the development of immunodeficiency disorders, such as X-linked agammaglobulinemia. 2. **Autoimmune diseases:** The expression of IGHV3-36 in T cells and innate lymphoid cells suggests that it may be involved in the regulation of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 3. **Cancer immunology:** IGHV3-36 may play a role in the regulation of cancer immunity, particularly in the development of T cell responses against tumor cells. 4. **Immunological surveillance:** IGHV3-36 may be involved in the regulation of immunological surveillance, particularly in the detection of tumor cells or infected cells. In conclusion, the IGHV3-36 gene is a complex and enigmatic gene that plays a multifaceted role in the regulation of immune responses. Further research is needed to fully understand the functions and clinical significance of this gene, but it is clear that IGHV3-36 is an important component of the immune system that warrants further investigation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.