Details for: TRAJ44

Gene ID: 28711

Symbol: TRAJ44

Ensembl ID: ENSG00000211845

Description: T cell receptor alpha joining 44

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 5.8533
    Cell Significance Index: 114.4400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.0052
    Cell Significance Index: 76.5700
  • Cell Name: mast cell (CL0000097)
    Fold Change: 2.8737
    Cell Significance Index: 37.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9019
    Cell Significance Index: 21.8500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.1254
    Cell Significance Index: 1.4900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0528
    Cell Significance Index: 0.6800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0366
    Cell Significance Index: 0.3900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0139
    Cell Significance Index: 0.2000
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0040
    Cell Significance Index: 0.0500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0174
    Cell Significance Index: -0.2300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0181
    Cell Significance Index: -0.2200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0200
    Cell Significance Index: -0.2200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0201
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0210
    Cell Significance Index: -0.1900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0242
    Cell Significance Index: -0.2500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0992
    Cell Significance Index: -1.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1564
    Cell Significance Index: -2.8900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1994
    Cell Significance Index: -3.2300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2014
    Cell Significance Index: -2.0400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2563
    Cell Significance Index: -2.4300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3079
    Cell Significance Index: -2.8800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3169
    Cell Significance Index: -3.5100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3199
    Cell Significance Index: -3.7100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3293
    Cell Significance Index: -2.8800
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.3400
    Cell Significance Index: -2.7900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.3489
    Cell Significance Index: -3.5200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3952
    Cell Significance Index: -4.6700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.4079
    Cell Significance Index: -3.5200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.5072
    Cell Significance Index: -4.5200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.5294
    Cell Significance Index: -4.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5590
    Cell Significance Index: -6.6600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.6647
    Cell Significance Index: -6.6300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.7097
    Cell Significance Index: -7.5300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.9851
    Cell Significance Index: -10.0000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.0274
    Cell Significance Index: -17.5600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -1.0806
    Cell Significance Index: -10.9200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -1.1110
    Cell Significance Index: -15.2300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -1.1378
    Cell Significance Index: -14.8500
  • Cell Name: platelet (CL0000233)
    Fold Change: -1.4251
    Cell Significance Index: -14.6600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -1.6225
    Cell Significance Index: -13.6900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -1.9473
    Cell Significance Index: -15.1500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -1.9745
    Cell Significance Index: -14.6900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -2.1761
    Cell Significance Index: -11.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRAJ44 is expressed in a wide range of immune cells, including double-negative thymocytes, erythrocytes, mast cells, CD8-positive T cells, alpha-beta T cells, megakaryocytes, plasmacytoid dendritic cells, and precursor B cells. 2. **Cellular Location:** TRAJ44 is primarily found in the nucleus, where it is involved in the regulation of gene expression and cell signaling pathways. 3. **Gene Structure:** The TRAJ44 gene consists of a single exon that encodes a protein with a high degree of similarity to other T cell receptor alpha joining proteins. **Pathways and Functions:** 1. **T Cell Receptor Alpha Joining:** TRAJ44 is involved in the joining of the T cell receptor alpha chain to the T cell receptor complex, which is essential for the recognition and response to antigens. 2. **Gene Regulation:** TRAJ44 regulates the expression of genes involved in the development and functioning of immune cells, including cytokine production and cell signaling pathways. 3. **Cell Signaling:** TRAJ44 interacts with other signaling proteins to regulate cell growth, differentiation, and survival. 4. **Immune Cell Development:** TRAJ44 is involved in the development and maturation of immune cells, including T cells, B cells, and dendritic cells. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions in the TRAJ44 gene may contribute to immunodeficiency disorders, such as severe combined immunodeficiency (SCID) or T cell leukemia. 2. **Cancer:** Aberrant expression of TRAJ44 has been linked to various types of cancer, including T cell leukemia and lymphoma. 3. **Autoimmune Diseases:** TRAJ44 may play a role in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, by regulating the expression of genes involved in immune cell function. 4. **Vaccine Development:** Understanding the role of TRAJ44 in the development and functioning of immune cells may lead to the development of novel vaccine strategies that target specific immune cell populations. In conclusion, TRAJ44 is a novel gene that plays a crucial role in the development and functioning of the immune system. Further research is needed to elucidate its mechanisms of action and clinical significance, which may lead to the development of novel therapeutic strategies for immunodeficiency disorders, cancer, and autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.