Details for: TRAJ12

Gene ID: 28743

Symbol: TRAJ12

Ensembl ID: ENSG00000211877

Description: T cell receptor alpha joining 12

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0122
    Cell Significance Index: 0.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0102
    Cell Significance Index: 0.1200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0016
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0001
    Cell Significance Index: 0.0300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0045
    Cell Significance Index: -0.0600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0049
    Cell Significance Index: -0.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0055
    Cell Significance Index: -0.0300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0078
    Cell Significance Index: -0.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0086
    Cell Significance Index: -0.0900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0095
    Cell Significance Index: -0.1000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0120
    Cell Significance Index: -0.1500
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0124
    Cell Significance Index: -0.1300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0134
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0138
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0139
    Cell Significance Index: -0.1300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0139
    Cell Significance Index: -0.1700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0151
    Cell Significance Index: -0.1600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0156
    Cell Significance Index: -0.1300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0157
    Cell Significance Index: -0.1400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0169
    Cell Significance Index: -0.1500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0175
    Cell Significance Index: -0.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0177
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0182
    Cell Significance Index: -0.1700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0210
    Cell Significance Index: -0.2300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0221
    Cell Significance Index: -0.2700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0226
    Cell Significance Index: -0.2400
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0232
    Cell Significance Index: -0.1900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0239
    Cell Significance Index: -0.2800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0253
    Cell Significance Index: -0.2200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0259
    Cell Significance Index: -0.2600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0298
    Cell Significance Index: -0.3000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0348
    Cell Significance Index: -0.3000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0367
    Cell Significance Index: -0.2700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0370
    Cell Significance Index: -0.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ12 is a gene that encodes a protein involved in the assembly and signaling of T cell receptors (TCRs), which are essential for the recognition of antigens by T cells. The protein is a joining component of the TCR alpha chain, which is a key component of the TCR complex. TRAJ12 is highly conserved across species, suggesting its evolutionary importance in the immune system. Its expression is widespread, with significant levels found in various immune cells, including B cells, T cells, and natural killer cells. **Pathways and Functions:** The TRAJ12 gene is involved in several key immune pathways, including: 1. **T cell receptor signaling:** TRAJ12 plays a crucial role in the assembly and signaling of TCRs, which is essential for the activation of T cells in response to antigens. 2. **Immunoglobulin class switching:** TRAJ12 has been implicated in the regulation of immunoglobulin class switching, a process by which B cells switch from producing one type of antibody to another. 3. **Cytokine production:** TRAJ12 is involved in the regulation of cytokine production, which is essential for the coordination of immune responses. 4. **Apoptosis regulation:** TRAJ12 has been shown to regulate apoptosis (programmed cell death) in immune cells, which is essential for the maintenance of immune homeostasis. **Clinical Significance:** The TRAJ12 gene has significant clinical implications, particularly in the context of immune-related disorders. Dysregulation of TRAJ12 has been implicated in various diseases, including: 1. **Autoimmune diseases:** TRAJ12 has been shown to play a role in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** TRAJ12 has been implicated in the regulation of cancer immune evasion, with its dysregulation contributing to the development of cancer. 3. **Immunodeficiency disorders:** TRAJ12 has been shown to play a role in the regulation of immune responses in immunodeficiency disorders, such as HIV/AIDS and chronic lymphocytic leukemia. In conclusion, the TRAJ12 gene is a complex and multifaceted component of the immune system, with significant implications for our understanding of immune-related disorders. Further research is needed to fully elucidate the functional significance of TRAJ12 and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.