Details for: IGKV1D 42

Gene ID: 28892

Symbol: IGKV1D 42

Ensembl ID: ENSG00000211633

Description: immunoglobulin kappa variable 1D-42 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 13.5874
    Cell Significance Index: 346.1800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 6.4355
    Cell Significance Index: 104.2300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.6389
    Cell Significance Index: 62.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.9720
    Cell Significance Index: 38.4600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 2.2620
    Cell Significance Index: 24.0300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.4635
    Cell Significance Index: 20.0700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1581
    Cell Significance Index: 2.3000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0511
    Cell Significance Index: -1.2800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0538
    Cell Significance Index: -0.5700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0704
    Cell Significance Index: -0.8300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0721
    Cell Significance Index: -0.4500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0858
    Cell Significance Index: -0.7200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0897
    Cell Significance Index: -1.1800
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: -0.1079
    Cell Significance Index: -0.8300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1130
    Cell Significance Index: -1.3500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1741
    Cell Significance Index: -2.0700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2111
    Cell Significance Index: -2.4900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3503
    Cell Significance Index: -4.6600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3602
    Cell Significance Index: -4.7400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.3672
    Cell Significance Index: -2.4500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3920
    Cell Significance Index: -4.1700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3951
    Cell Significance Index: -4.1600
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4116
    Cell Significance Index: -3.8200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4151
    Cell Significance Index: -4.9100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4189
    Cell Significance Index: -4.6800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4289
    Cell Significance Index: -4.7500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.4436
    Cell Significance Index: -4.1500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.4881
    Cell Significance Index: -4.1600
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.5008
    Cell Significance Index: -4.5800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.5112
    Cell Significance Index: -4.7600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5285
    Cell Significance Index: -5.4000
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.5823
    Cell Significance Index: -4.6800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.5991
    Cell Significance Index: -5.6800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.8959
    Cell Significance Index: -8.4100
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.9436
    Cell Significance Index: -4.7200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -1.4895
    Cell Significance Index: -13.5300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -1.8175
    Cell Significance Index: -18.4400
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -1.9601
    Cell Significance Index: -16.1800
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -2.0332
    Cell Significance Index: -18.1400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -3.8879
    Cell Significance Index: -35.7100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -3.9627
    Cell Significance Index: -41.0500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -4.3570
    Cell Significance Index: -23.3300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -4.5218
    Cell Significance Index: -39.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV1D 42 is a member of the immunoglobulin kappa (IgK) family, which plays a crucial role in the adaptive immune response. However, unlike other IgK genes, IGKV1D 42 is non-functional, indicating that it does not participate in the production of functional antibodies. Despite this, IGKV1D 42 is significantly expressed in various cell types, including erythrocytes and hematopoietic stem cells, suggesting its involvement in immune regulation and development. **Pathways and Functions:** IGKV1D 42 has been implicated in several key pathways, including the adaptive immune response, extracellular space, immune response, immunoglobulin complex, immunoglobulin production, and plasma membrane. Its expression in hematopoietic stem cells and megakaryocytes suggests that IGKV1D 42 plays a role in the development and maturation of immune cells. Additionally, its expression in erythrocytes and mast cells suggests that IGKV1D 42 may also be involved in the regulation of immune responses in these cell types. **Functions:** The exact function of IGKV1D 42 remains unclear, but its expression in various cell types suggests that it may play a role in modulating immune cell function and development. One possible function of IGKV1D 42 is to regulate the expression of other genes involved in the adaptive immune response. For example, IGKV1D 42 may interact with other immunoglobulin genes to regulate the production of functional antibodies. Alternatively, IGKV1D 42 may play a role in the regulation of immune cell development and maturation. **Clinical Significance:** IGKV1D 42 has significant clinical implications, particularly in the context of immunodeficiency disorders. Individuals with non-functional immunoglobulin genes, such as IGKV1D 42, may be at increased risk of developing autoimmune disorders or infections. Additionally, IGKV1D 42 may play a role in the regulation of immune responses in certain disease states, such as cancer or inflammatory disorders. Further research is needed to fully understand the clinical significance of IGKV1D 42 and its potential role in modulating immune responses. In conclusion, IGKV1D 42 is a non-functional immunoglobulin gene that is significantly expressed in various cell types, including erythrocytes and hematopoietic stem cells. Its expression in these cell types suggests that IGKV1D 42 plays a role in modulating immune cell function and development. Further research is needed to fully understand the key characteristics, pathways, and functions of IGKV1D 42, as well as its clinical significance in immunodeficiency disorders and immune regulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.