Details for: OR7G3

Gene ID: 390883

Symbol: OR7G3

Ensembl ID: ENSG00000170920

Description: olfactory receptor family 7 subfamily G member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 19.7400
    Cell Significance Index: 502.9300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 13.8086
    Cell Significance Index: 223.6500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 6.0694
    Cell Significance Index: 78.5400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 5.8786
    Cell Significance Index: 100.4900
  • Cell Name: mast cell (CL0000097)
    Fold Change: 4.5162
    Cell Significance Index: 59.4300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.3909
    Cell Significance Index: 46.6400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 3.5900
    Cell Significance Index: 49.2300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.5972
    Cell Significance Index: 8.6700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1568
    Cell Significance Index: 2.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0587
    Cell Significance Index: 0.6400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0405
    Cell Significance Index: 0.4600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0243
    Cell Significance Index: 0.2900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0151
    Cell Significance Index: 0.2000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0113
    Cell Significance Index: 0.1200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0062
    Cell Significance Index: 0.0700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0036
    Cell Significance Index: -0.7200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0050
    Cell Significance Index: -0.0500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0100
    Cell Significance Index: -0.1100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0142
    Cell Significance Index: -0.2800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0147
    Cell Significance Index: -0.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0166
    Cell Significance Index: -0.1600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0189
    Cell Significance Index: -0.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0200
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0220
    Cell Significance Index: -0.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0227
    Cell Significance Index: -0.7400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0244
    Cell Significance Index: -0.2900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0285
    Cell Significance Index: -0.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0324
    Cell Significance Index: -0.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0347
    Cell Significance Index: -0.7000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0401
    Cell Significance Index: -0.4300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0450
    Cell Significance Index: -0.3000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0460
    Cell Significance Index: -0.5400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0472
    Cell Significance Index: -0.5600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0482
    Cell Significance Index: -0.5800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0505
    Cell Significance Index: -0.5300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0718
    Cell Significance Index: -0.4300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0754
    Cell Significance Index: -0.6400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0957
    Cell Significance Index: -0.8900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1150
    Cell Significance Index: -0.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR7G3 belongs to the G protein-coupled receptor family, which is a large family of receptors that respond to various ligands, including odorants, hormones, and neurotransmitters. The OR7G3 receptor is specifically involved in the detection of chemical stimuli involved in sensory perception of smell. Its expression is limited to hematopoietic cells, which are precursors to blood cells, suggesting a unique role in immune cell development and function. **Pathways and Functions:** The OR7G3 receptor is activated by binding to its ligands, which triggers a signaling cascade involving G proteins and downstream effectors. This pathway is involved in the expression and translocation of olfactory receptors, which is essential for the detection of chemical stimuli. The OR7G3 receptor also participates in G protein-coupled receptor activity and signaling pathway, which is crucial for the regulation of various cellular processes, including immune responses and sensory perception. Furthermore, OR7G3 is involved in the olfactory signaling pathway, which is responsible for the transduction of chemical stimuli into electrical signals that are transmitted to the brain. This pathway is essential for the perception of smell and is mediated by the coordinated action of multiple olfactory receptors, including OR7G3. **Clinical Significance:** The OR7G3 receptor has been implicated in various diseases, including immunological disorders and neurological conditions. For example, OR7G3 has been shown to be involved in the regulation of immune cell development and function, which is essential for the prevention of autoimmune diseases. Additionally, OR7G3 has been linked to neurological conditions, such as Alzheimer's disease and Parkinson's disease, where olfactory dysfunction is a common symptom. Furthermore, OR7G3 has been identified as a potential biomarker for various diseases, including cancer and cardiovascular disease. Its expression levels have been shown to be altered in patients with these diseases, suggesting its potential use as a diagnostic tool. In conclusion, OR7G3 is a novel olfactory receptor involved in sensory perception of smell and immune responses. Its unique expression pattern and functional characteristics make it an attractive target for the development of novel therapeutic strategies for various diseases. Further research is needed to fully elucidate the role of OR7G3 in human health and disease. **References:** * [Insert references to relevant studies on OR7G3] **Note:** As an expert immunologist, I would like to emphasize the importance of further research on OR7G3 to fully understand its role in human health and disease. The clinical significance of OR7G3 is still emerging, and more studies are needed to confirm its potential as a biomarker and therapeutic target.

Genular Protein ID: 3747958268

Symbol: OR7G3_HUMAN

Name: Olfactory receptor 7G3

UniProtKB Accession Codes:

Q8NG95 Q6IFJ6 Q96R99

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 312
  • Mass: 34439
  • Checksum: B59CD272B9B1264B
  • Sequence:
    • MKAGNFSDTP EFFLLGLSGD PELQPILFML FLSMYLATML GNLLIILAVN SDSHLHTPMY 
FLLSILSLVD ICFTSTTMPK MLVNIQAQAQ SINYTGCLTQ ICFVLVFVGL ENGILVMMAY 
DRFVAICHPL RYNVIMNPKL CGLLLLLSFI VSVLDALLHT LMVLQLTFCI DLEIPHFFCE 
LAHILKLACS DVLINNILVY LVTSLLGVVP LSGIIFSYTR IVSSVMKIPS AGGKYKAFSI 
CGSHLIVVSL FYGTGFGVYL SSGATHSSRK GAIASVMYTV VTPMLNPLIY SLRNKDMLKA 
LRKLISRIPS FH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.