Details for: TRGJ1

Gene ID: 6968

Symbol: TRGJ1

Ensembl ID: ENSG00000211690

Description: T cell receptor gamma joining 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.5716
    Cell Significance Index: 19.8600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.0178
    Cell Significance Index: 9.2000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.4324
    Cell Significance Index: 4.4200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0156
    Cell Significance Index: 0.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0109
    Cell Significance Index: 0.1100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0029
    Cell Significance Index: -0.0500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0044
    Cell Significance Index: -0.0400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0054
    Cell Significance Index: -0.0900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0124
    Cell Significance Index: -0.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0130
    Cell Significance Index: -0.2600
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0192
    Cell Significance Index: -0.1400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0200
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0203
    Cell Significance Index: -0.1600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0203
    Cell Significance Index: -0.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0207
    Cell Significance Index: -0.2500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0225
    Cell Significance Index: -0.1900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0252
    Cell Significance Index: -0.2500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0257
    Cell Significance Index: -0.3300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0263
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0267
    Cell Significance Index: -0.2600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0287
    Cell Significance Index: -0.2600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0326
    Cell Significance Index: -0.2500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0334
    Cell Significance Index: -0.3700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0369
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0482
    Cell Significance Index: -0.6600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0488
    Cell Significance Index: -0.4300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0597
    Cell Significance Index: -0.6100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0629
    Cell Significance Index: -0.8200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0695
    Cell Significance Index: -0.8500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0729
    Cell Significance Index: -0.6400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0738
    Cell Significance Index: -0.6000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0772
    Cell Significance Index: -0.7200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0833
    Cell Significance Index: -0.7900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0881
    Cell Significance Index: -0.7300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0882
    Cell Significance Index: -0.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRGJ1 is a non-coding gene, meaning it does not encode a protein product. Instead, it regulates gene expression through alternative splicing, influencing the functioning of nearby genes. The gene's expression profile is characterized by its high levels in innate lymphoid cells, mature NK T cells, and certain subsets of T cells. Notably, TRGJ1 is also expressed in cells of the innate immune system, including natural killer cells and precursor B cells. This suggests that TRGJ1 plays a crucial role in the development and function of these cells. **Pathways and Functions:** TRGJ1's role in the immune response is mediated through its influence on gene expression. By regulating alternative splicing, TRGJ1 modulates the expression of nearby genes, which in turn affects the functioning of immune cells. For instance, TRGJ1 has been shown to regulate the expression of genes involved in the activation and proliferation of T cells. Additionally, TRGJ1 may play a role in the development and function of innate lymphoid cells, which are critical for the early response to pathogens. The specific pathways and functions of TRGJ1 are not yet fully elucidated; however, its expression in various immune cells suggests that it may be involved in: 1. **Regulation of T cell activation and proliferation**: TRGJ1 may modulate the expression of genes involved in T cell activation and proliferation, influencing the overall immune response. 2. **Development and function of innate lymphoid cells**: TRGJ1 may play a role in the development and function of innate lymphoid cells, which are critical for the early response to pathogens. 3. **Immune cell differentiation**: TRGJ1 may influence the differentiation of immune cells, such as natural killer cells and precursor B cells. **Clinical Significance:** The clinical significance of TRGJ1 is an area of active research. Given its expression in various immune cells, TRGJ1 may be involved in the pathogenesis of immune-related disorders, such as autoimmune diseases and cancer. For example: 1. **Autoimmune diseases**: TRGJ1 may contribute to the development of autoimmune diseases, such as type 1 diabetes and multiple sclerosis, by regulating the expression of genes involved in T cell activation and proliferation. 2. **Cancer**: TRGJ1 may play a role in the development and progression of cancer by influencing the expression of genes involved in immune evasion and tumor growth. 3. **Infectious diseases**: TRGJ1 may be involved in the pathogenesis of infectious diseases, such as HIV and tuberculosis, by regulating the expression of genes involved in immune cell activation and proliferation. In conclusion, the TRGJ1 gene is a complex and multifaceted component of the immune system, with far-reaching implications for our understanding of immune-related disorders. Further research is necessary to fully elucidate the role of TRGJ1 in the immune response and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.