Details for: ACTL9

Gene ID: 284382

Symbol: ACTL9

Ensembl ID: ENSG00000181786

Description: actin like 9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 4.97
    Marker Score: 1573
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 4.88
    Marker Score: 1572
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 4.33
    Marker Score: 1572
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 3.36
    Marker Score: 1486
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.98
    Marker Score: 1568
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 2.74
    Marker Score: 1572
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 2.72
    Marker Score: 1297
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.68
    Marker Score: 1572
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.52
    Marker Score: 1573
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.38
    Marker Score: 1565
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.28
    Marker Score: 1573
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.04
    Marker Score: 1571
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.97
    Marker Score: 1186
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.96
    Marker Score: 1572
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.73
    Marker Score: 1552
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.7
    Marker Score: 995
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.55
    Marker Score: 1573
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.5
    Marker Score: 1569
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.45
    Marker Score: 1539
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.4
    Marker Score: 1555
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.31
    Marker Score: 2664
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 1.28
    Marker Score: 1018
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.27
    Marker Score: 1486
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.21
    Marker Score: 1571
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7679
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.11
    Marker Score: 1571
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1565
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.96
    Marker Score: 29855
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.91
    Marker Score: 1567
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.91
    Marker Score: 828
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4913
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.85
    Marker Score: 5177
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.85
    Marker Score: 1552
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1605
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.74
    Marker Score: 1528
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.66
    Marker Score: 1565
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.58
    Marker Score: 1552
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.56
    Marker Score: 1558
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.44
    Marker Score: 1566
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.37
    Marker Score: 5825
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.37
    Marker Score: 2201

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Other Information

**Key Characteristics:** ACTL9 is a cytoplasmic protein that belongs to the actin-like protein family, characterized by its ability to interact with actin filaments and other proteins. Its structure consists of a unique actin-binding domain, which allows it to regulate actin filament dynamics and cytoskeletal organization. ACTL9 is highly expressed in various cell types, including immune cells, epithelial cells, and neuronal cells. **Pathways and Functions:** ACTL9 plays a crucial role in regulating actin filament organization and dynamics, which is essential for various cellular processes, including cell motility, fertilization, and synaptic transmission. Its interactions with actin-binding proteins and other signaling molecules modulate the activity of the actin cytoskeleton, influencing cell migration, adhesion, and signaling. Specifically, ACTL9 has been implicated in: * **Axonogenesis and neuronal development**: ACTL9 regulates the organization of the actin cytoskeleton in neuronal cells, influencing axon growth and guidance. * **Immune cell migration and activation**: ACTL9 modulates the motility and adhesion of immune cells, such as leukocytes and T cells, during immune responses. * **Fertilization and sperm motility**: ACTL9 is involved in regulating the motility and acrosomal reaction of sperm cells during fertilization. **Clinical Significance:** Dysregulation of ACTL9 has been implicated in various diseases and disorders, including: * **Neurodegenerative diseases**: Alterations in ACTL9 expression and function have been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. * **Immune disorders**: Dysregulation of ACTL9 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. * **Cancer**: ACTL9 expression has been altered in various types of cancer, including breast and lung cancer. In conclusion, ACTL9 plays a critical role in regulating actin filament organization and dynamics, influencing various cellular processes, including immune response and cellular motility. Further research is necessary to fully elucidate the mechanisms of ACTL9 and its implications in disease pathology.

Genular Protein ID: 722114504

Symbol: ACTL9_HUMAN

Name: Actin-like protein 9

UniProtKB Accession Codes:

Q8TC94 A8K893 Q6X960

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 33626338

Title: Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice.

PubMed ID: 33626338

DOI: 10.1016/j.ajhg.2021.02.004

Sequence Information:

  • Length: 416
  • Mass: 45516
  • Checksum: B4CE3043F99E2195
  • Sequence:
    • MDASRPKSSE SQSSLEAPRP GPNPSPNVVN KPLQRDSPGM VADRLPPKTG AVVIDMGTGT 
CKVGFAGQAS PTYTVATILG CQPKKPATSG QSGLQTFIGE AARVLPELTL VQPLRSGIVV 
DWDAAELIWR HLLEHDLRVA THDHPLLFSD PPFSPATNRE KLVEVAFESL RSPAMYVASQ 
SVLSVYAHGR VSGLVVDTGH GVTYTVPVFQ GYNLLHATER LDLAGNNLTA FLAEMLLQAG 
LPLGQQDLDL VENIKHHYCY VASDFQKEQA RPEQEYKRTL KLPDGRTVTL GKELFQCPEL 
LFNPPEVPGL SPVGLSTMAK QSLRKLSLEM RADLAQNVLL CGGSSLFTGF EGRFRAELLR 
ALPAETHVVV AAQPTRNFSV WIGGSILASL RAFQSCWVLR EQYEEQGPYI VYRKCY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.