Details for: TRAJ41

Gene ID: 28714

Symbol: TRAJ41

Ensembl ID: ENSG00000211848

Description: T cell receptor alpha joining 41

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0373
    Cell Significance Index: 0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0013
    Cell Significance Index: 0.0700
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0007
    Cell Significance Index: -0.2500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0050
    Cell Significance Index: -0.0900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0074
    Cell Significance Index: -0.1000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0082
    Cell Significance Index: -0.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0125
    Cell Significance Index: -0.2600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0133
    Cell Significance Index: -0.2600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0160
    Cell Significance Index: -0.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0165
    Cell Significance Index: -0.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0200
    Cell Significance Index: -0.2500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0208
    Cell Significance Index: -0.2600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0214
    Cell Significance Index: -0.2600
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0214
    Cell Significance Index: -0.1600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0220
    Cell Significance Index: -0.1200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0227
    Cell Significance Index: -0.2600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0230
    Cell Significance Index: -0.2600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0238
    Cell Significance Index: -0.2400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0247
    Cell Significance Index: -0.2500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0250
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0253
    Cell Significance Index: -0.2400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0254
    Cell Significance Index: -0.2700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0254
    Cell Significance Index: -0.2700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0255
    Cell Significance Index: -0.3400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0263
    Cell Significance Index: -0.3400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0266
    Cell Significance Index: -0.2700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0271
    Cell Significance Index: -0.3300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0275
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0278
    Cell Significance Index: -0.2600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0284
    Cell Significance Index: -0.2400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0284
    Cell Significance Index: -0.3100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0286
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0292
    Cell Significance Index: -0.2700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0297
    Cell Significance Index: -0.2600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0301
    Cell Significance Index: -0.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0307
    Cell Significance Index: -0.3600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0315
    Cell Significance Index: -0.2600
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0317
    Cell Significance Index: -0.2600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0321
    Cell Significance Index: -0.2600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0333
    Cell Significance Index: -0.3600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0341
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0408
    Cell Significance Index: -0.3700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0411
    Cell Significance Index: -0.3800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0436
    Cell Significance Index: -0.3500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0555
    Cell Significance Index: -0.4300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0609
    Cell Significance Index: -0.3300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0853
    Cell Significance Index: -0.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** TRAJ41 is expressed in multiple immune cell populations, including CD4+ and CD8+ T cells, innate lymphoid cells, and natural killer T cells. 2. **Cell Type Specificity:** The expression of TRAJ41 is cell-type specific, with varying levels of expression observed across different immune cell populations. 3. **Evolutionary Conservation:** TRAJ41 exhibits high sequence similarity across different species, suggesting its conservation across vertebrates. 4. **Gene Structure:** The TRAJ41 gene consists of multiple exons, which are spliced together to form a functional protein. **Pathways and Functions:** 1. **T Cell Receptor Signaling:** TRAJ41 is thought to play a role in T cell receptor signaling, which is crucial for the activation and proliferation of T cells. 2. **Cell Adhesion:** TRAJ41 may also contribute to cell adhesion processes, facilitating the interaction between T cells and antigen-presenting cells. 3. **Immune Cell Development:** TRAJ41 is involved in the development and maturation of alpha-beta T cells, which are essential for the adaptive immune response. 4. **Regulation of Immune Cell Proliferation:** TRAJ41 may modulate the proliferation of immune cells, influencing the overall immune response. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of TRAJ41 has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where T cell dysfunction plays a critical role. 2. **Cancer Immunotherapy:** TRAJ41 may also play a role in cancer immunotherapy, as it is involved in the activation and proliferation of T cells that recognize tumor antigens. 3. **Immunodeficiency Disorders:** Mutations in TRAJ41 may contribute to immunodeficiency disorders, such as severe combined immunodeficiency (SCID), where T cell function is impaired. 4. **Vaccine Development:** Understanding the role of TRAJ41 in T cell development and function may inform the development of novel vaccine strategies that leverage alpha-beta T cells. In conclusion, TRAJ41 is a critical gene involved in the development and function of alpha-beta T cells, with significant implications for our understanding of immune cell biology and disease. Further research is necessary to elucidate the precise mechanisms underlying TRAJ41's functions and to explore its potential as a therapeutic target for autoimmune diseases and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.