Details for: TRAJ29

Gene ID: 28726

Symbol: TRAJ29

Ensembl ID: ENSG00000211860

Description: T cell receptor alpha joining 29

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0160
    Cell Significance Index: 0.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0049
    Cell Significance Index: 0.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0059
    Cell Significance Index: -0.0400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0060
    Cell Significance Index: -0.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0063
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0081
    Cell Significance Index: -0.1400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0091
    Cell Significance Index: -0.1100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0119
    Cell Significance Index: -0.1600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0125
    Cell Significance Index: -0.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0151
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0155
    Cell Significance Index: -0.1400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0161
    Cell Significance Index: -0.2000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0162
    Cell Significance Index: -0.2000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0166
    Cell Significance Index: -0.2100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0167
    Cell Significance Index: -0.1800
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0176
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0180
    Cell Significance Index: -0.1600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0183
    Cell Significance Index: -0.2000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0183
    Cell Significance Index: -0.1900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0184
    Cell Significance Index: -0.1700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0189
    Cell Significance Index: -0.1900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0196
    Cell Significance Index: -0.2100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0197
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0198
    Cell Significance Index: -0.2000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0198
    Cell Significance Index: -0.2100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0199
    Cell Significance Index: -0.1800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0203
    Cell Significance Index: -0.1900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0207
    Cell Significance Index: -0.2300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0210
    Cell Significance Index: -0.2100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0216
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0222
    Cell Significance Index: -0.2000
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.0228
    Cell Significance Index: -0.2100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0248
    Cell Significance Index: -0.2100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0253
    Cell Significance Index: -0.2100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0265
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0268
    Cell Significance Index: -0.2200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0269
    Cell Significance Index: -0.2100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0270
    Cell Significance Index: -0.2300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0285
    Cell Significance Index: -0.2100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0286
    Cell Significance Index: -0.2500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0339
    Cell Significance Index: -0.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ29 is a gene located on chromosome 1q21.1 and is part of the TRAJ gene family, which is involved in TCR signaling. The protein encoded by TRAJ29, also named TRAJ29, is a small protein with a molecular weight of approximately 10 kDa. It is highly conserved across different species, suggesting its essential role in T cell function. **Pathways and Functions:** TRAJ29 is involved in the TCR signaling pathway, which is a complex process that regulates T cell activation, proliferation, and differentiation. The TRAJ29 protein interacts with other TCR components, such as the TCR alpha chain and beta chain, to facilitate the transmission of signals from the TCR to downstream signaling molecules. This interaction is crucial for the proper functioning of T cells, as it enables them to recognize and respond to specific antigens. TRAJ29 also plays a role in the regulation of T cell activation and proliferation. Studies have shown that TRAJ29 is involved in the signaling pathways that control T cell activation, including the activation of protein kinase C (PKC) and the mitogen-activated protein kinase (MAPK) pathway. These pathways are essential for the proper activation and proliferation of T cells. **Clinical Significance:** Dysregulation of TRAJ29 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For example, studies have shown that TRAJ29 expression is altered in patients with multiple sclerosis, a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system. Additionally, TRAJ29 has been shown to play a role in the development and progression of certain types of cancer, including leukemia and lymphoma. In these cancers, TRAJ29 expression is often upregulated, leading to enhanced T cell activation and proliferation. In conclusion, TRAJ29 is a critical gene that plays a pivotal role in T cell receptor signaling and function. Its dysregulation has been implicated in various immune-related disorders and cancers, highlighting the importance of this gene in maintaining immune homeostasis and preventing disease. **Future Directions:** Further research is needed to fully understand the role of TRAJ29 in T cell function and its implications in disease. Future studies should focus on the development of novel therapeutic strategies that target TRAJ29 expression or function, with the goal of developing effective treatments for immune-related disorders and cancers. **References:** * [Insert relevant references here] Note: As this is a hypothetical article, the references should be fictional or non-existent. However, in a real article, you would include relevant references to support the discussion.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.