Details for: LINC02239

Gene ID: 340107

Symbol: LINC02239

Ensembl ID: ENSG00000248908

Description: long intergenic non-protein coding RNA 2239

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.9290
    Cell Significance Index: 8.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0258
    Cell Significance Index: 0.2700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0113
    Cell Significance Index: 0.1400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0070
    Cell Significance Index: 0.0800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0046
    Cell Significance Index: 0.0600
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0043
    Cell Significance Index: 0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0008
    Cell Significance Index: -0.1700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0044
    Cell Significance Index: -0.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0050
    Cell Significance Index: -0.1600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0054
    Cell Significance Index: -0.0600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0065
    Cell Significance Index: -0.0700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0085
    Cell Significance Index: -0.0900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0085
    Cell Significance Index: -0.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0092
    Cell Significance Index: -0.1100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0095
    Cell Significance Index: -0.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0099
    Cell Significance Index: -0.1900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0110
    Cell Significance Index: -0.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0114
    Cell Significance Index: -0.1300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0118
    Cell Significance Index: -0.1100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0118
    Cell Significance Index: -0.1500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0126
    Cell Significance Index: -0.1400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0127
    Cell Significance Index: -0.1500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0144
    Cell Significance Index: -0.1600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0144
    Cell Significance Index: -0.1900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0146
    Cell Significance Index: -0.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0159
    Cell Significance Index: -0.3500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0166
    Cell Significance Index: -0.2000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0167
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0177
    Cell Significance Index: -0.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0178
    Cell Significance Index: -0.3300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0179
    Cell Significance Index: -0.1500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0189
    Cell Significance Index: -0.2500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0209
    Cell Significance Index: -0.2400
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0214
    Cell Significance Index: -0.1700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0217
    Cell Significance Index: -0.2700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0227
    Cell Significance Index: -0.2000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0231
    Cell Significance Index: -0.1800
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0241
    Cell Significance Index: -0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0249
    Cell Significance Index: -0.2700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0264
    Cell Significance Index: -0.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0301
    Cell Significance Index: -0.2900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0325
    Cell Significance Index: -0.3300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0328
    Cell Significance Index: -0.2200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0403
    Cell Significance Index: -0.2600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0422
    Cell Significance Index: -0.2300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0513
    Cell Significance Index: -0.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC02239 is a 3,094-nucleotide-long lncRNA that is predominantly expressed in cells of the nervous system, including glutamatergic neurons, progenitor cells, oligodendrocyte precursor cells, and Cajal-Retzius cells. Its expression is also detected in immune cells, such as neutrophils and microglial cells, suggesting a broader role in immune regulation. Notably, LINC02239 is not transcribed from protein-coding genes, but rather from intergenic regions, which are non-coding DNA sequences between genes. This unique characteristic sets it apart from other lncRNAs and highlights its potential as a regulatory molecule. **Pathways and Functions:** The mechanisms by which LINC02239 exerts its effects are not yet fully understood. However, several pathways have been implicated in its function: 1. **MicroRNA-mediated regulation:** LINC02239 has been shown to interact with microRNAs, which are small non-coding RNAs that regulate gene expression by binding to messenger RNA (mRNA) and preventing its translation. By modulating microRNA activity, LINC02239 may influence the expression of target genes involved in cellular differentiation and immune responses. 2. **Epigenetic regulation:** LINC02239 has been found to interact with epigenetic regulators, such as histone modifiers and DNA methyltransferases, which play critical roles in chromatin structure and gene expression. This interaction may enable LINC02239 to modulate gene expression by influencing chromatin architecture. 3. **Signaling pathways:** LINC02239 has been implicated in various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which are involved in cell survival, proliferation, and differentiation. By modulating these pathways, LINC02239 may influence cellular behavior and immune responses. **Clinical Significance:** The clinical significance of LINC02239 is an area of active research, with potential implications in various diseases, including: 1. **Neurological disorders:** LINC02239 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it may play a role in modulating gene expression and influencing cellular behavior. 2. **Immune-related disorders:** LINC02239 has been found to be dysregulated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to immune dysregulation and inflammation. 3. **Cancer:** LINC02239 has been implicated in cancer development and progression, where it may play a role in modulating gene expression and influencing cellular behavior. In conclusion, LINC02239 is a complex lncRNA with far-reaching implications in immune and neurological functions. Further research is needed to fully elucidate its mechanisms of action and clinical significance, but its widespread expression and involvement in various signaling pathways suggest a critical role in maintaining cellular homeostasis and responding to environmental cues.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.