Details for: IFNA7

Gene ID: 3444

Symbol: IFNA7

Ensembl ID: ENSG00000214042

Description: interferon alpha 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.9508
    Cell Significance Index: 49.7000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.0045
    Cell Significance Index: 13.0000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.8000
    Cell Significance Index: 12.9600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.6826
    Cell Significance Index: 11.6700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3698
    Cell Significance Index: 5.0700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.3287
    Cell Significance Index: 3.4900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0300
    Cell Significance Index: 0.3000
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0256
    Cell Significance Index: 0.3400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0098
    Cell Significance Index: -0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0228
    Cell Significance Index: -4.5700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0432
    Cell Significance Index: -0.5100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0448
    Cell Significance Index: -0.8900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0595
    Cell Significance Index: -0.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0671
    Cell Significance Index: -0.9600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0805
    Cell Significance Index: -1.1700
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0809
    Cell Significance Index: -0.8000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0882
    Cell Significance Index: -1.0400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0887
    Cell Significance Index: -0.9500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1077
    Cell Significance Index: -1.2900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1088
    Cell Significance Index: -1.3400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1213
    Cell Significance Index: -1.4500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1329
    Cell Significance Index: -1.7400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1331
    Cell Significance Index: -0.7900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1389
    Cell Significance Index: -1.6500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1441
    Cell Significance Index: -1.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1506
    Cell Significance Index: -2.7800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1616
    Cell Significance Index: -1.7000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1926
    Cell Significance Index: -1.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1937
    Cell Significance Index: -6.1700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1982
    Cell Significance Index: -2.1900
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2173
    Cell Significance Index: -2.2500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2198
    Cell Significance Index: -2.0800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2616
    Cell Significance Index: -2.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2954
    Cell Significance Index: -6.2700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3228
    Cell Significance Index: -3.4300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.4094
    Cell Significance Index: -2.2300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5371
    Cell Significance Index: -10.5000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.7107
    Cell Significance Index: -7.8700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8616
    Cell Significance Index: -10.7400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.8678
    Cell Significance Index: -9.9900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -1.0908
    Cell Significance Index: -8.8300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -1.1144
    Cell Significance Index: -9.7500
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.4390
    Cell Significance Index: -13.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual Functionality:** IFNA7 exhibits dual functionality, with both pro-inflammatory and anti-inflammatory properties. It can induce the production of pro-inflammatory cytokines, such as TNF-α and IL-6, while also promoting the production of anti-inflammatory cytokines, such as IL-10. 2. **Cell-Specific Expression:** IFNA7 is predominantly expressed in cells of the hematopoietic lineage, including erythrocytes, megakaryocytes, and precursor B cells. Its expression is also observed in cardiac endothelial cells and pericytes. 3. **Interferon Signaling:** IFNA7 is a key component of the type I interferon signaling pathway, which plays a critical role in the recognition of viral infections and the activation of immune responses. **Pathways and Functions:** 1. **Adaptive Immune Response:** IFNA7 contributes to the regulation of B cell differentiation and proliferation, which is essential for the development of humoral immunity. 2. **Innate Immune Response:** IFNA7 induces the production of pro-inflammatory cytokines, such as TNF-α and IL-6, which activate natural killer cells and promote the clearance of viral infections. 3. **Type I Interferon Signaling:** IFNA7 is a critical component of the type I interferon signaling pathway, which plays a key role in the recognition of viral infections and the activation of immune responses. 4. **Cytokine-Mediated Signaling:** IFNA7 modulates the activity of various cytokines, including IL-6, TNF-α, and IL-10, which are essential for the regulation of immune responses. **Clinical Significance:** Dysregulation of IFNA7 has been implicated in various immune-related diseases, including respiratory syncytial virus (RSV) infection, SARS-CoV-2 infection, and multiple sclerosis. The dysregulation of IFNA7 can lead to impaired immune responses, resulting in increased susceptibility to infections and autoimmune diseases. Furthermore, IFNA7 has been identified as a potential therapeutic target for the treatment of immune-related disorders, including autoimmune diseases and cancer. In conclusion, IFNA7 is a critical gene involved in the regulation of immune responses, with both pro-inflammatory and anti-inflammatory properties. Its unique expression pattern and dual functionality make it an essential component of the type I interferon signaling pathway. Further research is necessary to fully understand the role of IFNA7 in immune regulation and its potential therapeutic applications.

Genular Protein ID: 1015579354

Symbol: IFNA7_HUMAN

Name: Interferon alpha-7

UniProtKB Accession Codes:

P01567 Q14607 Q5VV14

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 9 Ensembl 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6181262

Title: Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster.

PubMed ID: 6181262

DOI: 10.1016/0022-2836(82)90261-3

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 2995168

Title: Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells.

PubMed ID: 2995168

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 8910771

Title: Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population.

PubMed ID: 8910771

DOI: 10.1089/jir.1996.16.853

Sequence Information:

  • Length: 189
  • Mass: 22107
  • Checksum: 9DF6F5C81E339A42
  • Sequence:
    • MARSFSLLMV VLVLSYKSIC SLGCDLPQTH SLRNRRALIL LAQMGRISPF SCLKDRHEFR 
FPEEEFDGHQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNDLE 
ACVIQEVGVE ETPLMNEDFI LAVRKYFQRI TLYLMEKKYS PCAWEVVRAE IMRSFSFSTN 
LKKGLRRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.