Details for: IFNA7

Gene ID: 3444

Symbol: IFNA7

Ensembl ID: ENSG00000214042

Description: interferon alpha 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.08
    Marker Score: 1155
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.09
    Marker Score: 1508
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.7
    Marker Score: 369
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.57
    Marker Score: 324
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 222
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.46
    Marker Score: 301
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 137
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.16
    Marker Score: 319
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.12
    Marker Score: 219
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1
    Marker Score: 58.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.08
    Marker Score: 1278
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.06
    Marker Score: 385
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 55.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.03
    Marker Score: 57
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.02
    Marker Score: 5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.02
    Marker Score: 97.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: T cell (CL0000084)
    Fold Change: 0
    Marker Score: 4.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 5

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Other Information

**Key characteristics:** * IFNA7 is a type I interferon, which are cytokines that are produced by infected cells and act on nearby cells. * It is a key regulator of the innate immune response to viral infection. * It is induced by viral infection and plays a role in the regulation of viral entry and infection. * It is expressed in a variety of cell types, including erythrocytes, lymphocytes, and endothelial cells. * It is a key regulator of the immune response to viral infection. **Pathways and functions:** * IFNA7 is a key regulator of the innate immune response to viral infection. * It is induced by viral infection and plays a role in the regulation of viral entry and infection. * It acts on nearby cells to promote viral entry and infection. * It is also involved in the regulation of inflammation and cell death. * It is a key regulator of the immune response to viral infection. **Clinical significance:** * IFNA7 is a potential therapeutic target for the treatment of viral infection. * It is a target for the development of vaccines to prevent viral infection. * It is a potential therapeutic target for the treatment of cancer. **Conclusion:** IFNA7 is a key regulator of the innate immune response to viral infection. It is a potential therapeutic target for the treatment of viral infection.

Genular Protein ID: 1015579354

Symbol: IFNA7_HUMAN

Name: Interferon alpha-7

UniProtKB Accession Codes:

P01567 Q14607 Q5VV14

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6181262

Title: Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster.

PubMed ID: 6181262

DOI: 10.1016/0022-2836(82)90261-3

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 2995168

Title: Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells.

PubMed ID: 2995168

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 8910771

Title: Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population.

PubMed ID: 8910771

DOI: 10.1089/jir.1996.16.853

Sequence Information:

  • Length: 189
  • Mass: 22107
  • Checksum: 9DF6F5C81E339A42
  • Sequence:
    • MARSFSLLMV VLVLSYKSIC SLGCDLPQTH SLRNRRALIL LAQMGRISPF SCLKDRHEFR 
FPEEEFDGHQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNDLE 
ACVIQEVGVE ETPLMNEDFI LAVRKYFQRI TLYLMEKKYS PCAWEVVRAE IMRSFSFSTN 
LKKGLRRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.