NBPF26 | ENSG00000273136 | NCBI 101060684

Details for: NBPF26

Gene ID: 101060684

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: NBPF26

Ensembl ID: ENSG00000273136

Description: NBPF member 26

Cell Significance Landscape

Display Count:

Associated with

Calcium ion binding
(GO:0005509)
Cytoplasm
(GO:0005737)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

plasmablast CL0000980

CSI 11.66

rCSI 9.18%

PRS 90.12
stromal cell CL0000499

CSI 7.19

rCSI 20.21%

PRS 82.18
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 6.34

rCSI 4.27%

PRS 96.04
conventional dendritic cell CL0000990

CSI 5.95

rCSI 4.97%

PRS 83.33
BEST4+ enteroycte CL4030026

CSI 4.72

rCSI 5.87%

PRS 86.94
mature B cell CL0000785

CSI 4.69

rCSI 4.08%

PRS 93.71
naive B cell CL0000788

CSI 4.48

rCSI 3.84%

PRS 90.89
unswitched memory B cell CL0000970

CSI 4.27

rCSI 3.6%

PRS 95.76
CD4-positive, alpha-beta memory T cell CL0000897

CSI 4.21

rCSI 3.02%

PRS 96.01
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 3.83

rCSI 2.87%

PRS 96.7
class switched memory B cell CL0000972

CSI 3.69

rCSI 2.76%

PRS 94.95
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 3.4

rCSI 2.39%

PRS 95.14
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 3.36

rCSI 1.98%

PRS 97.32
immature B cell CL0000816

CSI 3.29

rCSI 2.45%

PRS 94.17
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 3.28

rCSI 2.19%

PRS 93.89
fibroblast of lung CL0002553

CSI 3.27

rCSI 3.05%

PRS 87.82
melanocyte CL0000148

CSI 3.25

rCSI 2.41%

PRS 81.99
T follicular helper cell CL0002038

CSI 3.07

rCSI 2.3%

PRS 95.54
suprabasal keratinocyte CL4033013

CSI 3

rCSI 4.91%

PRS 55.63
secretory cell CL0000151

CSI 2.94

rCSI 3.07%

PRS 85.81
mature NK T cell CL0000814

CSI 2.8

rCSI 3.59%

PRS 92.05
bronchus fibroblast of lung CL2000093

CSI 2.73

rCSI 2.22%

PRS 86.32
epithelial cell of lower respiratory tract CL0002632

CSI 2.48

rCSI 1.93%

PRS 89.79
CD14-positive monocyte CL0001054

CSI 2.35

rCSI 2.92%

PRS 93.3
alveolar macrophage CL0000583

CSI 2.33

rCSI 3.83%

PRS 89.43
CD14-low, CD16-positive monocyte CL0002396

CSI 2.31

rCSI 1.78%

PRS 89.86
elicited macrophage CL0000861

CSI 2.26

rCSI 2.08%

PRS 92.34
non-classical monocyte CL0000875

CSI 2.25

rCSI 3.61%

PRS 92.85
intermediate monocyte CL0002393

CSI 2.14

rCSI 3.24%

PRS 91.22
enteric smooth muscle cell CL0002504

CSI 2.08

rCSI 2.97%

PRS 87.19
chondrocyte CL0000138

CSI 1.9

rCSI 3.02%

PRS 81.26
Mueller cell CL0000636

CSI 1.87

rCSI 4.28%

PRS 79.43
lung secretory cell CL1000272

CSI 1.87

rCSI 4.62%

PRS 87.13
conjunctival epithelial cell CL1000432

CSI 1.85

rCSI 2.83%

PRS 86.47
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 1.61

rCSI 8.09%

PRS 95.23
choroid plexus epithelial cell CL0000706

CSI 1.58

rCSI 2.58%

PRS 78.23
cardiac neuron CL0010022

CSI 1.56

rCSI 5%

PRS 84.91
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.37

rCSI 1.66%

PRS 92.49
alveolar adventitial fibroblast CL4028006

CSI 1.34

rCSI 2.11%

PRS 87.75
helper T cell CL0000912

CSI 1.2

rCSI 1.69%

PRS 83.72
melanocyte of skin CL1000458

CSI 1.07

rCSI 1.45%

PRS 55.71
basal cell of epidermis CL0002187

CSI 1.01

rCSI 1.8%

PRS 56.79
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.71

rCSI 0.86%

PRS 67.21
blood vessel smooth muscle cell CL0019018

CSI 0.36

rCSI 2.95%

PRS 82.67

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description

## Summary [NBPF26](/details-gene/101060684) is a protein-coding gene located on chromosome 1p11.2 and a member of the Neuroblastoma Breakpoint Family (NBPF). Functional annotations suggest it is a cytoplasmic protein involved in calcium ion binding ([GO:0005509](https://www.ebi.ac.uk/QuickGO/term/GO:0005509)). **Overall**, expression data reveals a highly significant role for [NBPF26](/details-gene/101060684) within the immune system, particularly in the lymphoid lineage. It is most prominently expressed in [plasmablasts](/details-cell/CL0000980) and shows strong enrichment across various stages of B and T cell maturation and activation, indicating a key function in adaptive immunity. ## Cellular Roles and Expression Landscape The expression profile of [NBPF26](/details-gene/101060684) strongly implicates it as a key component of the adaptive immune system. Its significance is most pronounced in the B-cell lineage, with the highest Cell Significance Index (CSI) observed in [plasmablasts](/details-cell/CL0000980) (CSI: 11.66), the precursors to antibody-secreting plasma cells. The gene's consistent expression across various B-cell differentiation stages, including [naive B cells](/details-cell/CL0000788), multiple memory B-cell subsets, and [immature B cells](/details-cell/CL0000816), suggests a continuous role throughout B-cell development and the humoral immune response. In addition to its prominence in B-cells, [NBPF26](/details-gene/101060684) is also significantly expressed in multiple T-lymphocyte populations. These include both cytotoxic and helper T-cell subsets, such as [central memory CD8-positive, alpha-beta T cells](/details-cell/CL0000907) and [central memory CD4-positive, alpha-beta T cells](/details-cell/CL0000904), as well as naive T-cells. This broad expression pattern suggests a shared function in the biology of both major lymphocyte arms. The gene's role in immunity is further supported by its notable expression in antigen-presenting [conventional dendritic cells](/details-cell/CL0000990) and both major subsets of human natural killer cells. Interestingly, [NBPF26](/details-gene/101060684) also shows significant expression in non-lymphoid cell types, including [stromal cells](/details-cell/CL0000499) and [BEST4+ enterocytes](/details-cell/CL4030026). Its presence in [stromal cells](/details-cell/CL0000499), which provide structural and signaling support in lymphoid organs, may point to a role in the tissue microenvironment that orchestrates immune responses. ## Pathways and Molecular Function Based on Gene Ontology annotations, [NBPF26](/details-gene/101060684) functions as a calcium ion binding protein ([GO:0005509](https://www.ebi.ac.uk/QuickGO/term/GO:0005509)) located within the cytoplasm ([GO:0005737](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)). Calcium signaling is a fundamental and ubiquitous second messenger system that is critical for lymphocyte function. In both B and T cells, fluctuations in intracellular calcium concentration are essential for triggering activation, proliferation, differentiation, and effector functions following antigen recognition. The high expression of [NBPF26](/details-gene/101060684) in activated lymphocyte populations, especially [plasmablasts](/details-cell/CL0000980), is consistent with a role in modulating these calcium-dependent signaling cascades, potentially by buffering calcium levels or acting as a calcium-dependent sensor that interfaces with downstream pathways. ## Research Directions The specific role of [NBPF26](/details-gene/101060684) in the immune system remains to be elucidated. Its strong association with terminal B-cell differentiation and its annotated calcium-binding function provide a clear basis for further investigation. **Proposed Hypotheses:** 1. Given its peak expression in [plasmablasts](/details-cell/CL0000980), [NBPF26](/details-gene/101060684) is a critical modulator of the terminal differentiation of B-cells into antibody-secreting cells. It may function by regulating the activity of calcium-dependent transcription factors, such as NFAT, which are essential for this process. 2. The significant expression in [stromal cells](/details-cell/CL0000499) suggests that [NBPF26](/details-gene/101060684) mediates calcium-dependent signaling within the lymphoid tissue microenvironment, potentially influencing lymphocyte survival, trafficking, or activation through interactions with immune cells. **Suggested Experimental Approach:** To test the hypothesis that [NBPF26](/details-gene/101060684) is essential for B-cell differentiation (Hypothesis 1), a targeted gene knockout study could be performed. Primary naive B-cells isolated from human donors could be subjected to CRISPR-Cas9-mediated knockout of [NBPF26](/details-gene/101060684). These knockout cells, alongside control cells, would then be cultured in vitro with stimuli (e.g., CD40L and IL-21) that promote differentiation into [plasmablasts](/details-cell/CL0000980). The impact of the knockout could be assessed by quantifying the efficiency of [plasmablast](/details-cell/CL0000980) generation via flow cytometry (using markers like CD19, CD38, and CD138), measuring immunoglobulin secretion by ELISA, and analyzing downstream transcriptional programs with RNA-sequencing. **Therapeutic Potential:** As a cytoplasmic calcium-binding protein highly expressed in antibody-producing [plasmablasts](/details-cell/CL0000980), [NBPF26](/details-gene/101060684) may represent a novel therapeutic target for B-cell-driven pathologies, such as autoimmune diseases or B-cell malignancies like multiple myeloma. Its intracellular location makes it unsuitable for antibody-based therapies but raises the possibility of developing small molecule inhibitors. A therapeutic strategy would likely focus on **inhibition** of its function to attenuate excessive B-cell activation and antibody production. The specificity of its high expression in lymphocytes could potentially minimize off-target effects compared to broad-spectrum immunosuppressants.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.