Details for: IGHJ2

Gene ID: 28481

Symbol: IGHJ2

Ensembl ID: ENSG00000211904

Description: immunoglobulin heavy joining 2

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B cell (CL0000236)
    Fold Change: 0.57
    Marker Score: 543
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.08
    Marker Score: 250
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.02
    Marker Score: 5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 4

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHJ2 is a gene that codes for a protein involved in the joining of heavy chain variable regions to the heavy chain constant region. This process is critical for the assembly of functional Ig molecules. The IGHJ2 gene is characterized by its unique structure, which allows it to interact with other genes involved in Ig synthesis, such as IGHV and IGHD. The gene is expressed in a variety of immune cells, including B cells, plasma cells, and plasmablasts, highlighting its broad role in the immune system. **Pathways and Functions:** IGHJ2 is involved in the joining of heavy chain variable regions to the heavy chain constant region, a process that is essential for the assembly of functional Ig molecules. This process occurs during the maturation of B cells and is mediated by the IGHJ2 protein. The IGHJ2 protein interacts with other genes involved in Ig synthesis, including IGHV and IGHD, to facilitate the assembly of functional Ig molecules. The resulting Ig molecules are then secreted into the bloodstream, where they can recognize and bind to specific antigens, triggering an immune response. The IGHJ2 gene also plays a role in the regulation of Ig synthesis. Studies have shown that IGHJ2 is involved in the control of Ig production, with dysregulation of IGHJ2 expression leading to altered Ig production and immune function. Furthermore, IGHJ2 has been implicated in the development of autoimmune diseases, such as rheumatoid arthritis, where dysregulation of Ig synthesis contributes to disease pathogenesis. **Clinical Significance:** The IGHJ2 gene has significant clinical implications, particularly in the context of autoimmune diseases. Dysregulation of IGHJ2 expression has been implicated in the development of various autoimmune conditions, including rheumatoid arthritis, lupus, and multiple sclerosis. Understanding the role of IGHJ2 in Ig synthesis and regulation is crucial for the development of novel therapeutic strategies aimed at modulating Ig production and immune function. In addition, IGHJ2 has been identified as a potential biomarker for certain diseases. For example, studies have shown that elevated levels of IGHJ2 expression are associated with certain types of cancer, such as breast cancer and lung cancer. Therefore, IGHJ2 may serve as a valuable diagnostic biomarker for these diseases. In conclusion, the IGHJ2 gene is a critical component of the immunoglobulin synthesis machinery, playing a pivotal role in the assembly and maturation of Ig heavy chains. Its expression is widespread among various immune cells, and dysregulation of IGHJ2 expression has been implicated in the development of autoimmune diseases and certain types of cancer. Further research is needed to fully elucidate the role of IGHJ2 in Ig synthesis and regulation, with potential implications for the development of novel therapeutic strategies and diagnostic biomarkers.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.