Details for: IGHJ2

Gene ID: 28481

Symbol: IGHJ2

Ensembl ID: ENSG00000211904

Description: immunoglobulin heavy joining 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0039
    Cell Significance Index: -0.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0114
    Cell Significance Index: -0.2900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0118
    Cell Significance Index: -0.1100
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0121
    Cell Significance Index: -0.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0129
    Cell Significance Index: -0.2500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0154
    Cell Significance Index: -0.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0155
    Cell Significance Index: -0.2900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0176
    Cell Significance Index: -0.2500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0197
    Cell Significance Index: -0.2200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0211
    Cell Significance Index: -0.2000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0222
    Cell Significance Index: -0.2900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0237
    Cell Significance Index: -0.2400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0245
    Cell Significance Index: -0.2900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0247
    Cell Significance Index: -0.2500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0251
    Cell Significance Index: -0.2800
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0262
    Cell Significance Index: -0.2400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0262
    Cell Significance Index: -0.2900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0280
    Cell Significance Index: -0.2600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0283
    Cell Significance Index: -0.2900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0287
    Cell Significance Index: -0.2700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0294
    Cell Significance Index: -0.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0297
    Cell Significance Index: -0.3100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0301
    Cell Significance Index: -0.3200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0317
    Cell Significance Index: -0.3700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0321
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0338
    Cell Significance Index: -0.3200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0340
    Cell Significance Index: -0.3200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0348
    Cell Significance Index: -0.3000
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0364
    Cell Significance Index: -0.3000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0375
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0375
    Cell Significance Index: -0.4600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0377
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0394
    Cell Significance Index: -0.3200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0400
    Cell Significance Index: -0.5100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0464
    Cell Significance Index: -0.4000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0482
    Cell Significance Index: -0.4900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0501
    Cell Significance Index: -0.6500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0503
    Cell Significance Index: -0.5400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0510
    Cell Significance Index: -0.5000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0527
    Cell Significance Index: -0.6200
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0544
    Cell Significance Index: -0.3500
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0547
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0567
    Cell Significance Index: -0.6400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0573
    Cell Significance Index: -0.6200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0588
    Cell Significance Index: -0.3200
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0646
    Cell Significance Index: -0.6400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0662
    Cell Significance Index: -0.3600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0714
    Cell Significance Index: -0.4900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0903
    Cell Significance Index: -0.6700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1100
    Cell Significance Index: -1.0300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1256
    Cell Significance Index: -1.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHJ2 is a gene that codes for a protein involved in the joining of heavy chain variable regions to the heavy chain constant region. This process is critical for the assembly of functional Ig molecules. The IGHJ2 gene is characterized by its unique structure, which allows it to interact with other genes involved in Ig synthesis, such as IGHV and IGHD. The gene is expressed in a variety of immune cells, including B cells, plasma cells, and plasmablasts, highlighting its broad role in the immune system. **Pathways and Functions:** IGHJ2 is involved in the joining of heavy chain variable regions to the heavy chain constant region, a process that is essential for the assembly of functional Ig molecules. This process occurs during the maturation of B cells and is mediated by the IGHJ2 protein. The IGHJ2 protein interacts with other genes involved in Ig synthesis, including IGHV and IGHD, to facilitate the assembly of functional Ig molecules. The resulting Ig molecules are then secreted into the bloodstream, where they can recognize and bind to specific antigens, triggering an immune response. The IGHJ2 gene also plays a role in the regulation of Ig synthesis. Studies have shown that IGHJ2 is involved in the control of Ig production, with dysregulation of IGHJ2 expression leading to altered Ig production and immune function. Furthermore, IGHJ2 has been implicated in the development of autoimmune diseases, such as rheumatoid arthritis, where dysregulation of Ig synthesis contributes to disease pathogenesis. **Clinical Significance:** The IGHJ2 gene has significant clinical implications, particularly in the context of autoimmune diseases. Dysregulation of IGHJ2 expression has been implicated in the development of various autoimmune conditions, including rheumatoid arthritis, lupus, and multiple sclerosis. Understanding the role of IGHJ2 in Ig synthesis and regulation is crucial for the development of novel therapeutic strategies aimed at modulating Ig production and immune function. In addition, IGHJ2 has been identified as a potential biomarker for certain diseases. For example, studies have shown that elevated levels of IGHJ2 expression are associated with certain types of cancer, such as breast cancer and lung cancer. Therefore, IGHJ2 may serve as a valuable diagnostic biomarker for these diseases. In conclusion, the IGHJ2 gene is a critical component of the immunoglobulin synthesis machinery, playing a pivotal role in the assembly and maturation of Ig heavy chains. Its expression is widespread among various immune cells, and dysregulation of IGHJ2 expression has been implicated in the development of autoimmune diseases and certain types of cancer. Further research is needed to fully elucidate the role of IGHJ2 in Ig synthesis and regulation, with potential implications for the development of novel therapeutic strategies and diagnostic biomarkers.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.