Details for: TRBV22 1

Gene ID: 28565

Symbol: TRBV22 1

Ensembl ID: ENSG00000240578

Description: T cell receptor beta variable 22-1 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.58
    Marker Score: 103,772
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,099
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.24
    Marker Score: 53,082
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8,292
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.77
    Marker Score: 6,858
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.17
    Marker Score: 3,190
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.85
    Marker Score: 3,191
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,847
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,072
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 406
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV22-1 is a member of the T cell receptor beta (TRBV) gene family, which encodes the variable region of the T cell receptor beta chain. The TRBV22-1 gene is a pseudogene, meaning that it has been rendered non-functional through genetic mutations or other mechanisms. Despite this, TRBV22-1 has been found to be expressed in a wide range of cell types, including immune cells, neurons, and progenitor cells. Its expression is not limited to the immune system, as it has also been detected in cells of the central nervous system, including glutamatergic neurons, oligodendrocyte precursor cells, and microglial cells. **Pathways and Functions:** The expression of TRBV22-1 has been linked to various cellular pathways, including: 1. **Immune function:** TRBV22-1 has been implicated in the regulation of immune responses, particularly in the context of T cell activation and differentiation. Its expression has been associated with the development of T cell-dependent immune responses. 2. **Neuronal development:** TRBV22-1 has been found to play a role in the development and maturation of neurons, particularly in the central nervous system. Its expression has been detected in glutamatergic neurons, oligodendrocyte precursor cells, and microglial cells. 3. **Cell signaling:** TRBV22-1 has been implicated in cell signaling pathways, including the regulation of cell growth, differentiation, and survival. **Clinical Significance:** The discovery of TRBV22-1 has significant implications for our understanding of immune function and neuronal development. Its expression in various cell types suggests that it may play a role in the development of autoimmune diseases, such as multiple sclerosis, and neurodegenerative disorders, such as Alzheimer's disease. Additionally, the pseudogenization of TRBV22-1 may provide insights into the mechanisms underlying the loss of immune function in certain populations. Furthermore, the expression of TRBV22-1 in microglial cells has been linked to the regulation of neuroinflammation, a key component of neurodegenerative diseases. The identification of TRBV22-1 as a regulator of microglial function has significant implications for the development of novel therapeutic strategies for neurodegenerative diseases. In conclusion, the TRBV22-1 gene, despite its designation as a pseudogene, has been found to have far-reaching implications in the immune system and beyond. Its expression in various cell types and its involvement in immune function, neuronal development, and cell signaling pathways make it an intriguing subject of study. As research continues to uncover the functions and clinical significance of TRBV22-1, we may uncover new avenues for the treatment and prevention of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.