Details for: TRBV22 1

Gene ID: 28565

Symbol: TRBV22 1

Ensembl ID: ENSG00000240578

Description: T cell receptor beta variable 22-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0466
    Cell Significance Index: 0.3100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0176
    Cell Significance Index: 0.2200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0055
    Cell Significance Index: 0.0500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0027
    Cell Significance Index: 0.0300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0014
    Cell Significance Index: 0.0100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: lymphocyte of B lineage (CL0000945)
    Fold Change: -0.0038
    Cell Significance Index: -0.0300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0047
    Cell Significance Index: -0.0400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0054
    Cell Significance Index: -0.0800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0065
    Cell Significance Index: -0.0700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: -0.0069
    Cell Significance Index: -0.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0071
    Cell Significance Index: -0.1500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0082
    Cell Significance Index: -0.0500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0091
    Cell Significance Index: -0.1200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0096
    Cell Significance Index: -0.0900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0103
    Cell Significance Index: -0.1100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0115
    Cell Significance Index: -0.1500
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0116
    Cell Significance Index: -0.1000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0118
    Cell Significance Index: -0.1200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0129
    Cell Significance Index: -0.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0138
    Cell Significance Index: -0.1300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0144
    Cell Significance Index: -0.1700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0146
    Cell Significance Index: -0.1800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0147
    Cell Significance Index: -0.1700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0150
    Cell Significance Index: -0.1800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0157
    Cell Significance Index: -0.1700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0160
    Cell Significance Index: -0.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0161
    Cell Significance Index: -0.1500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0172
    Cell Significance Index: -0.1900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0183
    Cell Significance Index: -0.1500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0191
    Cell Significance Index: -0.2000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0198
    Cell Significance Index: -0.3000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0199
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0209
    Cell Significance Index: -0.2300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0212
    Cell Significance Index: -0.2200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0218
    Cell Significance Index: -0.2200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0220
    Cell Significance Index: -0.2200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0232
    Cell Significance Index: -0.2000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0234
    Cell Significance Index: -0.2100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0242
    Cell Significance Index: -0.3300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0245
    Cell Significance Index: -0.2300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0261
    Cell Significance Index: -0.2200
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0282
    Cell Significance Index: -0.2300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0283
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0284
    Cell Significance Index: -0.2300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0286
    Cell Significance Index: -0.2200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0295
    Cell Significance Index: -0.3400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0300
    Cell Significance Index: -0.3400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0313
    Cell Significance Index: -0.3200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0755
    Cell Significance Index: -0.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV22-1 is a member of the T cell receptor beta (TRBV) gene family, which encodes the variable region of the T cell receptor beta chain. The TRBV22-1 gene is a pseudogene, meaning that it has been rendered non-functional through genetic mutations or other mechanisms. Despite this, TRBV22-1 has been found to be expressed in a wide range of cell types, including immune cells, neurons, and progenitor cells. Its expression is not limited to the immune system, as it has also been detected in cells of the central nervous system, including glutamatergic neurons, oligodendrocyte precursor cells, and microglial cells. **Pathways and Functions:** The expression of TRBV22-1 has been linked to various cellular pathways, including: 1. **Immune function:** TRBV22-1 has been implicated in the regulation of immune responses, particularly in the context of T cell activation and differentiation. Its expression has been associated with the development of T cell-dependent immune responses. 2. **Neuronal development:** TRBV22-1 has been found to play a role in the development and maturation of neurons, particularly in the central nervous system. Its expression has been detected in glutamatergic neurons, oligodendrocyte precursor cells, and microglial cells. 3. **Cell signaling:** TRBV22-1 has been implicated in cell signaling pathways, including the regulation of cell growth, differentiation, and survival. **Clinical Significance:** The discovery of TRBV22-1 has significant implications for our understanding of immune function and neuronal development. Its expression in various cell types suggests that it may play a role in the development of autoimmune diseases, such as multiple sclerosis, and neurodegenerative disorders, such as Alzheimer's disease. Additionally, the pseudogenization of TRBV22-1 may provide insights into the mechanisms underlying the loss of immune function in certain populations. Furthermore, the expression of TRBV22-1 in microglial cells has been linked to the regulation of neuroinflammation, a key component of neurodegenerative diseases. The identification of TRBV22-1 as a regulator of microglial function has significant implications for the development of novel therapeutic strategies for neurodegenerative diseases. In conclusion, the TRBV22-1 gene, despite its designation as a pseudogene, has been found to have far-reaching implications in the immune system and beyond. Its expression in various cell types and its involvement in immune function, neuronal development, and cell signaling pathways make it an intriguing subject of study. As research continues to uncover the functions and clinical significance of TRBV22-1, we may uncover new avenues for the treatment and prevention of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.