Details for: TRAJ42

Gene ID: 28713

Symbol: TRAJ42

Ensembl ID: ENSG00000211847

Description: T cell receptor alpha joining 42

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0146
    Cell Significance Index: 0.1700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0109
    Cell Significance Index: 0.1300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0075
    Cell Significance Index: 0.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0007
    Cell Significance Index: -0.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0055
    Cell Significance Index: -0.0300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0063
    Cell Significance Index: -0.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0086
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0090
    Cell Significance Index: -0.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0108
    Cell Significance Index: -0.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0134
    Cell Significance Index: -0.1600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0141
    Cell Significance Index: -0.1800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0146
    Cell Significance Index: -0.1800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0161
    Cell Significance Index: -0.2000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0168
    Cell Significance Index: -0.2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0170
    Cell Significance Index: -0.2100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0177
    Cell Significance Index: -0.1900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0181
    Cell Significance Index: -0.2100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0182
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0187
    Cell Significance Index: -0.1800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0188
    Cell Significance Index: -0.2500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0189
    Cell Significance Index: -0.1900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0190
    Cell Significance Index: -0.2100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0190
    Cell Significance Index: -0.2100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0190
    Cell Significance Index: -0.1900
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0198
    Cell Significance Index: -0.1800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0205
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0207
    Cell Significance Index: -0.2100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0207
    Cell Significance Index: -0.2200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0208
    Cell Significance Index: -0.2100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0209
    Cell Significance Index: -0.1800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0216
    Cell Significance Index: -0.2000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0218
    Cell Significance Index: -0.2300
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0219
    Cell Significance Index: -0.1800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0224
    Cell Significance Index: -0.2100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0225
    Cell Significance Index: -0.1900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0229
    Cell Significance Index: -0.2000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0237
    Cell Significance Index: -0.2100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0243
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0245
    Cell Significance Index: -0.2500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0257
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0259
    Cell Significance Index: -0.2100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0263
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0263
    Cell Significance Index: -0.2500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0266
    Cell Significance Index: -0.2100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0282
    Cell Significance Index: -0.2100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0304
    Cell Significance Index: -0.2600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0380
    Cell Significance Index: -0.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** TRAJ42 is located on chromosome 1q21.1 and is significantly expressed in various immune cells, including CD8-positive, alpha-beta T cells, B cells, and innate lymphoid cells. 2. **Cell Types:** TRAJ42 is expressed in multiple cell types, including alpha-beta T cells, B cells, retinal rod cells, double-positive, alpha-beta thymocytes, mature alpha-beta T cells, mature gamma-delta T cells, mature NK T cells, effector CD8-positive, alpha-beta T cells, effector memory CD8-positive, alpha-beta T cells, and innate lymphoid cells. 3. **Function:** The exact function of TRAJ42 is not well understood, but it is likely involved in the regulation of immune cell development, differentiation, and function. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAJ42 is involved in the adaptive immune response, which is a specific response to pathogens and involves the activation of immune cells, such as T cells and B cells. 2. **Plasma Membrane:** TRAJ42 is located on the plasma membrane of immune cells, where it is likely involved in cell-cell interactions and signaling pathways. 3. **Cell Signaling:** TRAJ42 may be involved in cell signaling pathways, including the activation of immune cells and the regulation of immune responses. **Clinical Significance:** 1. **Immunodeficiency:** Mutations in TRAJ42 may lead to immunodeficiency, a condition characterized by impaired immune function and increased susceptibility to infections. 2. **Autoimmunity:** TRAJ42 may also play a role in autoimmunity, a condition characterized by the immune system's attack on self-antigens. 3. **Cancer:** TRAJ42 may be involved in cancer, as it is expressed in various types of cancer cells, including T cells and B cells. 4. **Neurological Disorders:** TRAJ42 is also expressed in retinal rod cells, suggesting a potential role in neurological disorders, such as retinitis pigmentosa. In conclusion, TRAJ42 is a crucial gene involved in the development and function of various immune cells. Further research is needed to fully understand its role in the immune system and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.