Details for: TRAJ40

Gene ID: 28715

Symbol: TRAJ40

Ensembl ID: ENSG00000211849

Description: T cell receptor alpha joining 40

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0346
    Cell Significance Index: 0.3900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0054
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0063
    Cell Significance Index: -0.1100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0082
    Cell Significance Index: -0.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0104
    Cell Significance Index: -0.2000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0127
    Cell Significance Index: -0.1500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0142
    Cell Significance Index: -0.1100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0160
    Cell Significance Index: -0.1400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0162
    Cell Significance Index: -0.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0164
    Cell Significance Index: -0.2100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0171
    Cell Significance Index: -0.1600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0173
    Cell Significance Index: -0.2000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0175
    Cell Significance Index: -0.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0177
    Cell Significance Index: -0.1700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0187
    Cell Significance Index: -0.2400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0190
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0202
    Cell Significance Index: -0.2000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0205
    Cell Significance Index: -0.2400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0208
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0208
    Cell Significance Index: -0.2100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0209
    Cell Significance Index: -0.2200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0212
    Cell Significance Index: -0.2700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0216
    Cell Significance Index: -0.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0218
    Cell Significance Index: -0.2600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0220
    Cell Significance Index: -0.1900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0226
    Cell Significance Index: -0.2500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0229
    Cell Significance Index: -0.2300
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0231
    Cell Significance Index: -0.2100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0236
    Cell Significance Index: -0.2200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0236
    Cell Significance Index: -0.2800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0245
    Cell Significance Index: -0.2100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0245
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0246
    Cell Significance Index: -0.2300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0247
    Cell Significance Index: -0.2500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0248
    Cell Significance Index: -0.2600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0252
    Cell Significance Index: -0.2200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0254
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0260
    Cell Significance Index: -0.2400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0262
    Cell Significance Index: -0.2200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0275
    Cell Significance Index: -0.2200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0275
    Cell Significance Index: -0.1500
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0276
    Cell Significance Index: -0.1900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0279
    Cell Significance Index: -0.2900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0294
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0300
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0309
    Cell Significance Index: -0.2500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0328
    Cell Significance Index: -0.3300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0349
    Cell Significance Index: -0.2600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0654
    Cell Significance Index: -0.5600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0689
    Cell Significance Index: -0.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-type specificity:** TRAJ40 is expressed in a diverse range of cell types, including retinal rod cells, leukocytes, innate lymphoid cells, and various subsets of T cells (e.g., CD8-positive, CD4-positive, alpha-beta T cells, and NK T cells). This widespread expression underscores its potential as a key regulator of immune responses. 2. **Evolutionary conservation:** The TRAJ40 gene is conserved across species, suggesting its essential role in maintaining immune homeostasis and responding to pathogens. 3. **Lack of known functional studies:** Despite its widespread expression and potential involvement in immune regulation, TRAJ40 has received relatively little attention in functional studies, highlighting the need for further research to uncover its molecular mechanisms. **Pathways and Functions:** 1. **T cell receptor signaling:** TRAJ40 is likely involved in modulating T cell receptor signaling, which is critical for the activation and regulation of T cell responses. Its expression in alpha-beta T cells and other T cell subsets suggests a role in fine-tuning T cell function. 2. **Immune cell development:** TRAJ40 may also play a part in the development and maturation of immune cells, including T cells and innate lymphoid cells. Its expression in thymocytes and mature NK T cells supports this hypothesis. 3. **Cell-cell interactions:** TRAJ40 may facilitate cell-cell interactions between immune cells, such as the coordination of T cell and dendritic cell interactions, which is essential for effective immune responses. **Clinical Significance:** 1. **Autoimmune diseases:** Dysregulation of TRAJ40 expression or function may contribute to the development of autoimmune diseases, such as multiple sclerosis or type 1 diabetes, by impairing immune tolerance and promoting excessive immune activation. 2. **Cancer immunotherapy:** TRAJ40 may also play a role in cancer immunotherapy, where its expression and function could influence the efficacy of T cell-based therapies. 3. **Infectious diseases:** TRAJ40's involvement in innate lymphoid cell function and T cell responses suggests its potential role in shaping the immune response to pathogens, particularly in the context of respiratory or gastrointestinal infections. In conclusion, TRAJ40 is a gene of ongoing research in immunology, with its expression in diverse cell types and potential involvement in T cell receptor signaling, immune cell development, and cell-cell interactions. Further investigation is necessary to fully elucidate its molecular mechanisms and clinical significance, which may ultimately reveal new avenues for the treatment of autoimmune and infectious diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.