Details for: TRAJ16

Gene ID: 28739

Symbol: TRAJ16

Ensembl ID: ENSG00000211873

Description: T cell receptor alpha joining 16

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.0023
    Cell Significance Index: 0.0200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0026
    Cell Significance Index: -0.0400
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0038
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0054
    Cell Significance Index: -1.0900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0075
    Cell Significance Index: -0.1300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0085
    Cell Significance Index: -0.1200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0215
    Cell Significance Index: -0.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0219
    Cell Significance Index: -0.9700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0244
    Cell Significance Index: -0.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0253
    Cell Significance Index: -0.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0268
    Cell Significance Index: -0.3200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0390
    Cell Significance Index: -0.4600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0476
    Cell Significance Index: -0.9300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0550
    Cell Significance Index: -1.0800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0601
    Cell Significance Index: -0.7500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0604
    Cell Significance Index: -0.5600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0622
    Cell Significance Index: -0.7800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0623
    Cell Significance Index: -0.7800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0643
    Cell Significance Index: -0.7800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0679
    Cell Significance Index: -0.9000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0698
    Cell Significance Index: -0.9100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0705
    Cell Significance Index: -0.9500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0711
    Cell Significance Index: -0.9400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0713
    Cell Significance Index: -0.7900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0787
    Cell Significance Index: -0.9300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0801
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0814
    Cell Significance Index: -0.8600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0834
    Cell Significance Index: -0.9600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0840
    Cell Significance Index: -0.9300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0845
    Cell Significance Index: -0.8600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0923
    Cell Significance Index: -0.9300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0939
    Cell Significance Index: -0.8900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0949
    Cell Significance Index: -0.7300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0951
    Cell Significance Index: -0.8900
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.0953
    Cell Significance Index: -0.9300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0972
    Cell Significance Index: -0.8500
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0992
    Cell Significance Index: -1.0400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1023
    Cell Significance Index: -0.9600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1043
    Cell Significance Index: -0.8600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1048
    Cell Significance Index: -1.1400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1055
    Cell Significance Index: -0.9100
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.1083
    Cell Significance Index: -1.0300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1093
    Cell Significance Index: -1.1100
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1128
    Cell Significance Index: -0.9300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1140
    Cell Significance Index: -0.9800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1142
    Cell Significance Index: -0.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1174
    Cell Significance Index: -1.1300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1176
    Cell Significance Index: -0.9200
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1196
    Cell Significance Index: -0.8900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1449
    Cell Significance Index: -0.7900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.3051
    Cell Significance Index: -0.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression in Immune Cells:** TRAJ16 is specifically expressed in a wide range of immune cells, including CD4+ and CD8+ T cells, natural killer T cells, innate lymphoid cells, and exhausted T cells. This widespread expression suggests that TRAJ16 plays a critical role in regulating immune cell function across different immune compartments. 2. **Gene Structure:** The TRAJ16 gene consists of a single exon that encodes a protein with a unique structure, comprising an immunoglobulin-like domain and a transmembrane domain. 3. **Cellular Localization:** TRAJ16 is primarily expressed on the surface of immune cells, where it can interact with its ligands and regulate immune responses. **Pathways and Functions:** 1. **T Cell Receptor Signaling:** TRAJ16 is an essential component of the T cell receptor (TCR) complex, which is responsible for recognizing and binding to specific antigens. The interaction between TRAJ16 and its ligands triggers a signaling cascade that regulates T cell activation, proliferation, and differentiation. 2. **Immune Cell Activation:** TRAJ16 plays a key role in regulating immune cell activation, including the activation of CD4+ and CD8+ T cells, natural killer T cells, and innate lymphoid cells. This activation is crucial for the initiation of immune responses against pathogens and foreign antigens. 3. **Regulation of Immune Cell Function:** TRAJ16 also regulates immune cell function, including the suppression of excessive immune responses and the promotion of immune tolerance. This is achieved through the interaction between TRAJ16 and its ligands, which modulate the activity of immune cells and prevent autoimmunity. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of TRAJ16 has been implicated in various autoimmune diseases, including multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Modulation of TRAJ16 expression and function may provide a novel therapeutic strategy for the treatment of these diseases. 2. **Cancer Immunotherapy:** TRAJ16 has been identified as a potential target for cancer immunotherapy, as its dysregulation can lead to the suppression of anti-tumor immune responses. Restoring TRAJ16 expression and function may enhance the efficacy of cancer immunotherapy. 3. **Infectious Diseases:** TRAJ16 plays a critical role in regulating immune responses against pathogens, including viruses and bacteria. Dysregulation of TRAJ16 has been implicated in various infectious diseases, including HIV and tuberculosis. Modulation of TRAJ16 expression and function may provide a novel therapeutic strategy for the treatment of these diseases. In conclusion, TRAJ16 is a crucial regulator of immune cell function, and its dysregulation has been implicated in various immune-mediated diseases. Further research is necessary to fully elucidate the mechanisms of TRAJ16 function and to explore its potential as a therapeutic target for the treatment of autoimmune and infectious diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.