Details for: TRBV29OR9 2

Gene ID: 6958

Symbol: TRBV29OR9 2

Ensembl ID: ENSG00000223394

Description: T cell receptor beta variable 29/OR9-2 (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1327
    Cell Significance Index: 1.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0948
    Cell Significance Index: 85.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0341
    Cell Significance Index: 5.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0060
    Cell Significance Index: 0.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0033
    Cell Significance Index: -0.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0103
    Cell Significance Index: -1.9600
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0258
    Cell Significance Index: -0.2700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0350
    Cell Significance Index: -0.3300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0499
    Cell Significance Index: -0.3300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0519
    Cell Significance Index: -0.7800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0573
    Cell Significance Index: -0.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0596
    Cell Significance Index: -0.8700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0606
    Cell Significance Index: -1.0400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0634
    Cell Significance Index: -0.4800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0646
    Cell Significance Index: -0.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0715
    Cell Significance Index: -11.6400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0764
    Cell Significance Index: -0.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1022
    Cell Significance Index: -6.2700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1655
    Cell Significance Index: -1.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1827
    Cell Significance Index: -36.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2460
    Cell Significance Index: -24.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4337
    Cell Significance Index: -47.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4450
    Cell Significance Index: -15.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5420
    Cell Significance Index: -37.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0840
    Cell Significance Index: -31.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1911
    Cell Significance Index: -41.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.2236
    Cell Significance Index: -73.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3183
    Cell Significance Index: -41.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3436
    Cell Significance Index: -43.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.4772
    Cell Significance Index: -36.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5143
    Cell Significance Index: -49.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.6819
    Cell Significance Index: -41.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.8343
    Cell Significance Index: -39.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -2.0938
    Cell Significance Index: -42.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -2.1081
    Cell Significance Index: -31.7700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -2.1259
    Cell Significance Index: -42.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.1322
    Cell Significance Index: -45.4100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -2.5113
    Cell Significance Index: -50.0800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.7202
    Cell Significance Index: -56.4300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -2.9127
    Cell Significance Index: -18.0700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -4.2695
    Cell Significance Index: -45.3600
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -4.2981
    Cell Significance Index: -25.2300
  • Cell Name: neuron (CL0000540)
    Fold Change: -4.8543
    Cell Significance Index: -46.0200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -5.9284
    Cell Significance Index: -56.9100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -6.0324
    Cell Significance Index: -43.8400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -7.4476
    Cell Significance Index: -46.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV29OR9-2 is a member of the T cell receptor beta (TRBV) family, which is essential for the recognition of antigens by T cells. However, unlike other TRBV genes, TRBV29OR9-2 is non-functional, suggesting that its expression may serve alternative purposes. The gene is predominantly expressed in cells of the gastrointestinal tract, where it plays a key role in maintaining the integrity of the gut epithelium and regulating immune responses. **Pathways and Functions:** TRBV29OR9-2 is involved in several key pathways and processes, including: 1. **Gut Homeostasis:** TRBV29OR9-2 is expressed in intestinal crypt stem cells, which are responsible for the renewal of the gut epithelium. The gene's expression in these cells suggests that it plays a role in maintaining the balance of the gut microbiome and regulating the immune response to commensal bacteria. 2. **Immune Regulation:** TRBV29OR9-2 is also expressed in goblet cells, which produce mucus that helps to protect the gut epithelium from pathogens. The gene's expression in these cells suggests that it may regulate the immune response to luminal antigens. 3. **Epithelial Cell Signaling:** TRBV29OR9-2 is expressed in epithelial cells, which are the primary cells that line the gut epithelium. The gene's expression in these cells suggests that it may regulate signaling pathways that are involved in the maintenance of epithelial homeostasis. **Clinical Significance:** The TRBV29OR9-2 gene has significant implications for our understanding of immune system dysregulation in various diseases, including: 1. **Inflammatory Bowel Disease (IBD):** TRBV29OR9-2's expression in goblet cells and epithelial cells suggests that it may play a role in regulating the immune response to luminal antigens, which is a key feature of IBD. 2. **Cancer:** The gene's expression in intestinal crypt stem cells suggests that it may play a role in maintaining the balance of the gut microbiome, which is a critical factor in the development of colorectal cancer. 3. **Immune System Disorders:** TRBV29OR9-2's expression in various cell types within the gastrointestinal tract suggests that it may play a role in regulating immune responses and maintaining homeostasis in the gut-associated lymphoid tissue (GALT). In conclusion, TRBV29OR9-2 is a non-functional gene that plays a critical role in regulating immune responses and maintaining homeostasis in the gut-associated lymphoid tissue (GALT). Further research is needed to fully elucidate the functions of TRBV29OR9-2 and its implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.