Details for: SNORD59A

Gene ID: 26789

Symbol: SNORD59A

Ensembl ID: ENSG00000207031

Description: small nucleolar RNA, C/D box 59A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0729
    Cell Significance Index: 1.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0131
    Cell Significance Index: 0.3500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0006
    Cell Significance Index: -0.1700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0025
    Cell Significance Index: -0.0700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0052
    Cell Significance Index: -0.0700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0055
    Cell Significance Index: -0.0500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0058
    Cell Significance Index: -0.0600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0060
    Cell Significance Index: -0.0500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0070
    Cell Significance Index: -0.0800
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0072
    Cell Significance Index: -0.0600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0089
    Cell Significance Index: -0.0800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0107
    Cell Significance Index: -0.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0138
    Cell Significance Index: -0.1800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0139
    Cell Significance Index: -0.1500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0198
    Cell Significance Index: -0.1200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0207
    Cell Significance Index: -0.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0215
    Cell Significance Index: -0.2600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0239
    Cell Significance Index: -0.2500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0247
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0260
    Cell Significance Index: -0.2700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0267
    Cell Significance Index: -0.3600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0280
    Cell Significance Index: -0.3200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0289
    Cell Significance Index: -0.3400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0309
    Cell Significance Index: -0.3900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0319
    Cell Significance Index: -0.3900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0321
    Cell Significance Index: -0.3500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0336
    Cell Significance Index: -0.3600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0348
    Cell Significance Index: -0.4400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0356
    Cell Significance Index: -0.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0364
    Cell Significance Index: -0.4300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0379
    Cell Significance Index: -0.4500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0388
    Cell Significance Index: -0.4700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0391
    Cell Significance Index: -0.5100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0419
    Cell Significance Index: -0.5200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0446
    Cell Significance Index: -0.5100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0467
    Cell Significance Index: -0.4800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0475
    Cell Significance Index: -0.4700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0511
    Cell Significance Index: -0.5200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0519
    Cell Significance Index: -0.3600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0588
    Cell Significance Index: -0.5200
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0609
    Cell Significance Index: -0.6700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0635
    Cell Significance Index: -0.5200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0682
    Cell Significance Index: -0.5300
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0767
    Cell Significance Index: -0.3700
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: -0.1000
    Cell Significance Index: -0.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Small nucleolar RNA (snoRNA):** SNORD59A belongs to the C/D box snoRNA family, which is involved in various aspects of RNA processing, including ribosome biogenesis, pre-rRNA modification, and the regulation of gene expression. 2. **Expression in diverse cell types:** SNORD59A is expressed in pericytes, goblet cells, cardiac endothelial cells, neoplastic cells, and other cell types, suggesting its involvement in multiple cellular processes and disease states. 3. **C/D box motif:** The presence of a C/D box motif in the SNORD59A gene is a hallmark of snoRNAs, which are essential for the modification of ribosomal RNA and the regulation of gene expression. **Pathways and Functions:** 1. **RNA processing:** SNORD59A is involved in the processing of RNA, specifically in the modification of ribosomal RNA and the regulation of gene expression. Its C/D box motif is essential for this process, which involves the recognition and modification of specific RNA sequences. 2. **Cellular differentiation:** SNORD59A is expressed in cells that undergo significant differentiation, such as pericytes and goblet cells. Its expression is also observed in neoplastic cells, suggesting its involvement in the regulation of cellular differentiation and proliferation. 3. **Nucleolus:** The nucleolus is a critical component of the cell where ribosome biogenesis occurs. SNORD59A is involved in the regulation of ribosome biogenesis, which is essential for cell growth and proliferation. **Clinical Significance:** 1. **Cancer association:** The expression of SNORD59A in neoplastic cells suggests its involvement in cancer development and progression. Further studies are needed to understand the specific role of SNORD59A in cancer and its potential as a biomarker or therapeutic target. 2. **Cellular differentiation disorders:** The expression of SNORD59A in cells that undergo significant differentiation suggests its involvement in cellular differentiation disorders, such as congenital anomalies or developmental disorders. 3. **Cardiovascular disease:** The expression of SNORD59A in cardiac endothelial cells and cardiac muscle myoblasts suggests its involvement in cardiovascular disease, including conditions such as atherosclerosis and heart failure. In conclusion, SNORD59A is a small nucleolar RNA that plays a critical role in RNA processing and cellular differentiation. Its expression in diverse cell types and its involvement in various cellular processes suggest its importance in understanding disease mechanisms and developing new therapeutic strategies. Further studies are needed to elucidate the specific role of SNORD59A in disease and its potential as a biomarker or therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.