Details for: TRAV9 1

Gene ID: 28678

Symbol: TRAV9 1

Ensembl ID: ENSG00000211783

Description: T cell receptor alpha variable 9-1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.87
    Marker Score: 160,878
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.05
    Marker Score: 51,861
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.13
    Marker Score: 7,580
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.38
    Marker Score: 6,146
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.67
    Marker Score: 2,688
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.94
    Marker Score: 2,172
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.86
    Marker Score: 3,200
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 1.58
    Marker Score: 817
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.57
    Marker Score: 938
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.47
    Marker Score: 1,223
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.45
    Marker Score: 1,220
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.38
    Marker Score: 1,223
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.28
    Marker Score: 1,221
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.24
    Marker Score: 721
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,687
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.13
    Marker Score: 1,224
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.12
    Marker Score: 1,219
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.04
    Marker Score: 1,221
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.98
    Marker Score: 70,626
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.97
    Marker Score: 46,860
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.96
    Marker Score: 29,907
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.93
    Marker Score: 834
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1,505
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.9
    Marker Score: 714
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,228
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,854
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.82
    Marker Score: 744
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,205
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.75
    Marker Score: 2,321
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 709
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.71
    Marker Score: 1,163
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.71
    Marker Score: 1,216
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.69
    Marker Score: 1,224
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.62
    Marker Score: 1,224
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.58
    Marker Score: 1,223
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.56
    Marker Score: 1,266
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.29
    Marker Score: 1,224
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.28
    Marker Score: 1,222
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.25
    Marker Score: 1,223
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.1
    Marker Score: 1,219

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV9.1 is a member of the TRAV gene family, which is responsible for encoding the variable regions of the TCR alpha chain. This gene is specifically expressed in a variety of cell types, including T cells, neurons, and endothelial cells. Notably, TRAV9.1 is predominantly expressed in T cells, where it contributes to the development and function of these immune cells. The expression of TRAV9.1 is tightly regulated, and its dysregulation has been implicated in various immune-related disorders. **Pathways and Functions:** TRAV9.1 plays a critical role in the adaptive immune response by participating in the recognition and binding of antigens to T cells. The TCR complex, which includes the TRAV9.1 gene, is a complex of proteins that recognizes and binds to specific antigens, leading to the activation of T cells. This process involves the activation of signaling pathways, including the NF-κB and MAPK pathways, which regulate the transcription of genes involved in immune responses. TRAV9.1 also interacts with other components of the TCR complex, including the TCR beta chain and CD3 molecules, to facilitate antigen recognition and binding. In addition to its role in the adaptive immune response, TRAV9.1 has been implicated in the regulation of other cellular processes, including cell proliferation, differentiation, and survival. For example, studies have shown that TRAV9.1 is expressed in neurons and plays a role in the regulation of neuronal function and development. Furthermore, TRAV9.1 has been shown to interact with other genes and signaling pathways involved in the regulation of endothelial cell function and vascular development. **Clinical Significance:** Dysregulation of TRAV9.1 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For example, TRAV9.1 has been shown to contribute to the development of autoimmune diseases such as multiple sclerosis and type 1 diabetes. Additionally, TRAV9.1 has been implicated in the progression of cancer, particularly in the context of T cell-mediated immune responses. In addition to its role in immune-related disorders, TRAV9.1 has also been implicated in the regulation of other diseases, including neurological disorders and cardiovascular disease. For example, studies have shown that TRAV9.1 is expressed in neurons and plays a role in the regulation of neuronal function and development. Furthermore, TRAV9.1 has been shown to interact with other genes and signaling pathways involved in the regulation of endothelial cell function and vascular development. In conclusion, TRAV9.1 is a complex gene that plays a critical role in the regulation of the adaptive immune response. Its dysregulation has been implicated in various immune-related disorders, including autoimmune diseases and cancer. Further research is needed to fully understand the mechanisms by which TRAV9.1 regulates immune responses and to explore its potential as a therapeutic target for the treatment of immune-related disorders. **Future Directions:** Future studies should aim to further elucidate the mechanisms by which TRAV9.1 regulates immune responses and to explore its potential as a therapeutic target for the treatment of immune-related disorders. This may involve the development of novel therapeutic strategies, such as gene therapy or immunomodulatory therapies, that target TRAV9.1 and its downstream signaling pathways. Additionally, further research is needed to understand the role of TRAV9.1 in other cellular processes, such as cell proliferation, differentiation, and survival, and to explore its potential implications for the development of novel therapeutic strategies for other diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.