Details for: TRAV9 1

Gene ID: 28678

Symbol: TRAV9 1

Ensembl ID: ENSG00000211783

Description: T cell receptor alpha variable 9-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.2526
    Cell Significance Index: 1.7400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.1055
    Cell Significance Index: 1.0700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0054
    Cell Significance Index: 0.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0089
    Cell Significance Index: -0.1500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0094
    Cell Significance Index: -0.1000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0105
    Cell Significance Index: -0.1000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0112
    Cell Significance Index: -0.1300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0118
    Cell Significance Index: -0.1100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0128
    Cell Significance Index: -0.1200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0133
    Cell Significance Index: -0.1100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0140
    Cell Significance Index: -0.1400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0148
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0153
    Cell Significance Index: -0.1200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0160
    Cell Significance Index: -0.1400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0163
    Cell Significance Index: -0.1600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0164
    Cell Significance Index: -0.1900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0166
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0168
    Cell Significance Index: -0.1700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0169
    Cell Significance Index: -0.1700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0174
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0177
    Cell Significance Index: -0.1800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0190
    Cell Significance Index: -0.1600
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0198
    Cell Significance Index: -0.1500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0206
    Cell Significance Index: -0.1600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0209
    Cell Significance Index: -0.2200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0219
    Cell Significance Index: -0.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0232
    Cell Significance Index: -0.2900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0234
    Cell Significance Index: -0.3200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0241
    Cell Significance Index: -0.3000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0256
    Cell Significance Index: -0.2400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0274
    Cell Significance Index: -0.3000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0280
    Cell Significance Index: -0.3000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0281
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0287
    Cell Significance Index: -0.2700
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0289
    Cell Significance Index: -0.3300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0324
    Cell Significance Index: -0.3200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0334
    Cell Significance Index: -0.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0407
    Cell Significance Index: -0.4800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0446
    Cell Significance Index: -0.4800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0449
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0449
    Cell Significance Index: -0.4200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0492
    Cell Significance Index: -0.1500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0532
    Cell Significance Index: -0.5600
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0544
    Cell Significance Index: -0.5800
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0601
    Cell Significance Index: -0.6300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0668
    Cell Significance Index: -0.7800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0678
    Cell Significance Index: -0.8300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0680
    Cell Significance Index: -0.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0771
    Cell Significance Index: -0.7400
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0863
    Cell Significance Index: -0.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV9.1 is a member of the TRAV gene family, which is responsible for encoding the variable regions of the TCR alpha chain. This gene is specifically expressed in a variety of cell types, including T cells, neurons, and endothelial cells. Notably, TRAV9.1 is predominantly expressed in T cells, where it contributes to the development and function of these immune cells. The expression of TRAV9.1 is tightly regulated, and its dysregulation has been implicated in various immune-related disorders. **Pathways and Functions:** TRAV9.1 plays a critical role in the adaptive immune response by participating in the recognition and binding of antigens to T cells. The TCR complex, which includes the TRAV9.1 gene, is a complex of proteins that recognizes and binds to specific antigens, leading to the activation of T cells. This process involves the activation of signaling pathways, including the NF-κB and MAPK pathways, which regulate the transcription of genes involved in immune responses. TRAV9.1 also interacts with other components of the TCR complex, including the TCR beta chain and CD3 molecules, to facilitate antigen recognition and binding. In addition to its role in the adaptive immune response, TRAV9.1 has been implicated in the regulation of other cellular processes, including cell proliferation, differentiation, and survival. For example, studies have shown that TRAV9.1 is expressed in neurons and plays a role in the regulation of neuronal function and development. Furthermore, TRAV9.1 has been shown to interact with other genes and signaling pathways involved in the regulation of endothelial cell function and vascular development. **Clinical Significance:** Dysregulation of TRAV9.1 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For example, TRAV9.1 has been shown to contribute to the development of autoimmune diseases such as multiple sclerosis and type 1 diabetes. Additionally, TRAV9.1 has been implicated in the progression of cancer, particularly in the context of T cell-mediated immune responses. In addition to its role in immune-related disorders, TRAV9.1 has also been implicated in the regulation of other diseases, including neurological disorders and cardiovascular disease. For example, studies have shown that TRAV9.1 is expressed in neurons and plays a role in the regulation of neuronal function and development. Furthermore, TRAV9.1 has been shown to interact with other genes and signaling pathways involved in the regulation of endothelial cell function and vascular development. In conclusion, TRAV9.1 is a complex gene that plays a critical role in the regulation of the adaptive immune response. Its dysregulation has been implicated in various immune-related disorders, including autoimmune diseases and cancer. Further research is needed to fully understand the mechanisms by which TRAV9.1 regulates immune responses and to explore its potential as a therapeutic target for the treatment of immune-related disorders. **Future Directions:** Future studies should aim to further elucidate the mechanisms by which TRAV9.1 regulates immune responses and to explore its potential as a therapeutic target for the treatment of immune-related disorders. This may involve the development of novel therapeutic strategies, such as gene therapy or immunomodulatory therapies, that target TRAV9.1 and its downstream signaling pathways. Additionally, further research is needed to understand the role of TRAV9.1 in other cellular processes, such as cell proliferation, differentiation, and survival, and to explore its potential implications for the development of novel therapeutic strategies for other diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.