Details for: TRAJ32

Gene ID: 28723

Symbol: TRAJ32

Ensembl ID: ENSG00000211857

Description: T cell receptor alpha joining 32

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 7.6588
    Cell Significance Index: 149.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2879
    Cell Significance Index: 31.2000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.4307
    Cell Significance Index: 5.6500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.2685
    Cell Significance Index: 3.5100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2405
    Cell Significance Index: 3.9000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0293
    Cell Significance Index: 0.1600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0280
    Cell Significance Index: 0.3200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0074
    Cell Significance Index: 0.0800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0004
    Cell Significance Index: 0.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0038
    Cell Significance Index: -0.1700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0056
    Cell Significance Index: -0.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0081
    Cell Significance Index: -0.1100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0140
    Cell Significance Index: -0.1900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0159
    Cell Significance Index: -0.2100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0160
    Cell Significance Index: -0.2100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0170
    Cell Significance Index: -0.2100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0189
    Cell Significance Index: -0.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0193
    Cell Significance Index: -0.2300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0197
    Cell Significance Index: -0.2000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0203
    Cell Significance Index: -0.2100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0207
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0208
    Cell Significance Index: -0.2200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0217
    Cell Significance Index: -0.2400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0224
    Cell Significance Index: -0.2500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0244
    Cell Significance Index: -0.2200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0245
    Cell Significance Index: -0.2900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0250
    Cell Significance Index: -0.2100
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0256
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0267
    Cell Significance Index: -0.2700
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0269
    Cell Significance Index: -0.3100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0306
    Cell Significance Index: -0.3100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0324
    Cell Significance Index: -0.2800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0324
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0346
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0374
    Cell Significance Index: -0.3500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0377
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0394
    Cell Significance Index: -0.3700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0399
    Cell Significance Index: -0.3000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0414
    Cell Significance Index: -0.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0417
    Cell Significance Index: -0.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0482
    Cell Significance Index: -0.8900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0549
    Cell Significance Index: -0.4800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0569
    Cell Significance Index: -0.4800
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0920
    Cell Significance Index: -0.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **T cell receptor alpha joining 32**: TRAJ32 is a protein that interacts with the T cell receptor alpha (TCRα) chain, facilitating the assembly and stabilization of the TCR complex. 2. **Widespread expression**: TRAJ32 is expressed in various immune cells, including mature gamma-delta T cells, alpha-beta T cells, and innate lymphoid cells, as well as non-immune cells like retinal rod cells. 3. **Cell type-specific expression**: The expression of TRAJ32 varies across different cell types, suggesting its involvement in distinct immune functions and regulatory mechanisms. 4. **Evolutionary conservation**: TRAJ32 is conserved across species, indicating its essential role in immune function and evolution. **Pathways and Functions:** 1. **T cell receptor signaling**: TRAJ32 interacts with the TCRα chain to form a functional TCR complex, enabling the recognition of antigen-presenting cells and the activation of T cells. 2. **Immune cell development**: TRAJ32 plays a crucial role in the development and maturation of T cells, B cells, and innate lymphoid cells, ensuring proper immune cell function and regulation. 3. **Regulation of immune responses**: TRAJ32 modulates immune responses by influencing the activation, proliferation, and differentiation of immune cells, as well as the production of cytokines and chemokines. 4. **Cell-cell interactions**: TRAJ32 mediates cell-cell interactions between immune cells, facilitating the coordination of immune responses and the prevention of autoimmunity. **Clinical Significance:** 1. **Autoimmune diseases**: Dysregulation of TRAJ32 expression and function has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and type 1 diabetes. 2. **Cancer immunotherapy**: TRAJ32 has been identified as a potential target for cancer immunotherapy, as its dysregulation can impair the function of immune cells and promote tumor growth. 3. **Immunodeficiency disorders**: Mutations in the TRAJ32 gene have been associated with immunodeficiency disorders, highlighting its importance in maintaining immune homeostasis. 4. **Infectious diseases**: TRAJ32 plays a critical role in the response to infectious diseases, such as tuberculosis and HIV, and its dysregulation can contribute to disease progression. In conclusion, TRAJ32 is a vital component of the adaptive immune system, and its dysregulation can have significant implications for immune function and disease. Further research is necessary to fully elucidate the mechanisms by which TRAJ32 regulates immune responses and to explore its therapeutic potential in the context of immune-mediated diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.