Details for: IGKV2 40

Gene ID: 28916

Symbol: IGKV2 40

Ensembl ID: ENSG00000273962

Description: immunoglobulin kappa variable 2-40

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.54
    Marker Score: 300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.36
    Marker Score: 493
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.21
    Marker Score: 111
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 113
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 168
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 8

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin kappa variable region**: The IGKV2-40 gene belongs to the immunoglobulin kappa (IgK) family, which is a subset of the antibody-producing immunoglobulins. The kappa variable region is responsible for recognizing and binding to specific antigens. 2. **Variable region 2-40**: The IGKV2-40 gene encodes a specific kappa variable region, which is designated as 2-40. This region is unique and plays a critical role in the specificity and affinity of IgK antibodies. 3. **Expression in hematopoietic cells**: The IGKV2-40 gene is expressed in various hematopoietic cell types, including hematopoietic stem cells, precursor B cells, and memory B cells. This widespread expression suggests a crucial role in the development and function of the immune system. **Pathways and Functions:** 1. **Adaptive immune response**: The IGKV2-40 gene is involved in the adaptive immune response, specifically in the production of IgK antibodies. IgK antibodies play a key role in recognizing and binding to specific antigens, which triggers an immune response. 2. **Immunoglobulin complex formation**: The IGKV2-40 gene contributes to the formation of immunoglobulin complexes, which are essential for the recognition and neutralization of pathogens. 3. **Plasma membrane localization**: The IGKV2-40 gene is localized to the plasma membrane, where it interacts with other proteins to regulate immune responses. 4. **Antigen recognition**: The kappa variable region encoded by the IGKV2-40 gene recognizes and binds to specific antigens, leading to the activation of immune cells and the production of antibodies. **Clinical Significance:** 1. **Immunodeficiency disorders**: Mutations in the IGKV2-40 gene have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). XLA is characterized by a severe deficiency in IgK antibodies, leading to increased susceptibility to infections. 2. **Autoimmune diseases**: Abnormal expression of the IGKV2-40 gene has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. Dysregulation of the immune response can lead to the production of autoantibodies and tissue damage. 3. **Cancer immunology**: The IGKV2-40 gene has been implicated in the development of cancer, particularly in the context of immunotherapy. The expression of IgK antibodies can influence the tumor microenvironment and modulate the immune response. In conclusion, the IGKV2-40 gene plays a critical role in the human immune system, particularly in the production of IgK antibodies and the recognition of antigens. Its dysregulation has been linked to various immunodeficiency disorders and autoimmune diseases, highlighting the importance of its proper expression and function. Further research into the IGKV2-40 gene and its role in the immune system is necessary to fully understand its significance and develop effective therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.