Details for: IGKV2 40

Gene ID: 28916

Symbol: IGKV2 40

Ensembl ID: ENSG00000273962

Description: immunoglobulin kappa variable 2-40

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.4897
    Cell Significance Index: 12.4800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2788
    Cell Significance Index: 4.5200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.2576
    Cell Significance Index: 4.4000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0641
    Cell Significance Index: 0.8800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.0255
    Cell Significance Index: 0.2600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0447
    Cell Significance Index: -0.4800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0614
    Cell Significance Index: -0.8900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0745
    Cell Significance Index: -0.9800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0749
    Cell Significance Index: -0.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0813
    Cell Significance Index: -0.8200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0826
    Cell Significance Index: -0.5500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0846
    Cell Significance Index: -0.9500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0907
    Cell Significance Index: -1.1300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0994
    Cell Significance Index: -1.2200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0997
    Cell Significance Index: -1.0500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1052
    Cell Significance Index: -1.3800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1178
    Cell Significance Index: -1.4000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1193
    Cell Significance Index: -1.2200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1217
    Cell Significance Index: -1.4800
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1252
    Cell Significance Index: -1.0900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1296
    Cell Significance Index: -1.4000
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1298
    Cell Significance Index: -1.1500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1348
    Cell Significance Index: -1.4300
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1374
    Cell Significance Index: -1.3000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1438
    Cell Significance Index: -1.4600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1495
    Cell Significance Index: -1.5900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1501
    Cell Significance Index: -1.5800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1614
    Cell Significance Index: -1.3300
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1618
    Cell Significance Index: -1.3000
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1684
    Cell Significance Index: -1.5400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1753
    Cell Significance Index: -1.6400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1878
    Cell Significance Index: -2.0800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1901
    Cell Significance Index: -1.6400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1943
    Cell Significance Index: -1.6400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1976
    Cell Significance Index: -2.3400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1977
    Cell Significance Index: -1.8400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2027
    Cell Significance Index: -1.6200
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: -0.2098
    Cell Significance Index: -1.2100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2104
    Cell Significance Index: -2.1500
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.2136
    Cell Significance Index: -1.6400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2234
    Cell Significance Index: -2.0800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2237
    Cell Significance Index: -1.9600
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.2266
    Cell Significance Index: -1.4700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2282
    Cell Significance Index: -2.6900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2317
    Cell Significance Index: -2.2000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.2332
    Cell Significance Index: -2.0800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2752
    Cell Significance Index: -2.8100
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.3028
    Cell Significance Index: -1.6100
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.3137
    Cell Significance Index: -1.5700
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.3396
    Cell Significance Index: -1.6000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3611
    Cell Significance Index: -2.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin kappa variable region**: The IGKV2-40 gene belongs to the immunoglobulin kappa (IgK) family, which is a subset of the antibody-producing immunoglobulins. The kappa variable region is responsible for recognizing and binding to specific antigens. 2. **Variable region 2-40**: The IGKV2-40 gene encodes a specific kappa variable region, which is designated as 2-40. This region is unique and plays a critical role in the specificity and affinity of IgK antibodies. 3. **Expression in hematopoietic cells**: The IGKV2-40 gene is expressed in various hematopoietic cell types, including hematopoietic stem cells, precursor B cells, and memory B cells. This widespread expression suggests a crucial role in the development and function of the immune system. **Pathways and Functions:** 1. **Adaptive immune response**: The IGKV2-40 gene is involved in the adaptive immune response, specifically in the production of IgK antibodies. IgK antibodies play a key role in recognizing and binding to specific antigens, which triggers an immune response. 2. **Immunoglobulin complex formation**: The IGKV2-40 gene contributes to the formation of immunoglobulin complexes, which are essential for the recognition and neutralization of pathogens. 3. **Plasma membrane localization**: The IGKV2-40 gene is localized to the plasma membrane, where it interacts with other proteins to regulate immune responses. 4. **Antigen recognition**: The kappa variable region encoded by the IGKV2-40 gene recognizes and binds to specific antigens, leading to the activation of immune cells and the production of antibodies. **Clinical Significance:** 1. **Immunodeficiency disorders**: Mutations in the IGKV2-40 gene have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). XLA is characterized by a severe deficiency in IgK antibodies, leading to increased susceptibility to infections. 2. **Autoimmune diseases**: Abnormal expression of the IGKV2-40 gene has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. Dysregulation of the immune response can lead to the production of autoantibodies and tissue damage. 3. **Cancer immunology**: The IGKV2-40 gene has been implicated in the development of cancer, particularly in the context of immunotherapy. The expression of IgK antibodies can influence the tumor microenvironment and modulate the immune response. In conclusion, the IGKV2-40 gene plays a critical role in the human immune system, particularly in the production of IgK antibodies and the recognition of antigens. Its dysregulation has been linked to various immunodeficiency disorders and autoimmune diseases, highlighting the importance of its proper expression and function. Further research into the IGKV2-40 gene and its role in the immune system is necessary to fully understand its significance and develop effective therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.