Details for: IGKJ3

Gene ID: 28948

Symbol: IGKJ3

Ensembl ID: ENSG00000211595

Description: immunoglobulin kappa joining 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.0363
    Cell Significance Index: 0.3000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.0032
    Cell Significance Index: 0.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0049
    Cell Significance Index: -0.0500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0078
    Cell Significance Index: -0.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0112
    Cell Significance Index: -0.3000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0195
    Cell Significance Index: -0.5000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0258
    Cell Significance Index: -0.2300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0347
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0362
    Cell Significance Index: -0.3400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0474
    Cell Significance Index: -0.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0481
    Cell Significance Index: -0.9400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0493
    Cell Significance Index: -0.8000
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0510
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0546
    Cell Significance Index: -1.0100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0552
    Cell Significance Index: -0.6900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0555
    Cell Significance Index: -0.6200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0639
    Cell Significance Index: -0.7600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0676
    Cell Significance Index: -1.1500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0710
    Cell Significance Index: -0.7200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0721
    Cell Significance Index: -0.6400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0762
    Cell Significance Index: -1.0000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0825
    Cell Significance Index: -1.0300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0836
    Cell Significance Index: -0.9700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0838
    Cell Significance Index: -0.9900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0867
    Cell Significance Index: -1.0700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0889
    Cell Significance Index: -0.8400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0919
    Cell Significance Index: -0.9800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0924
    Cell Significance Index: -0.9800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0940
    Cell Significance Index: -1.0000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0980
    Cell Significance Index: -0.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0982
    Cell Significance Index: -0.9400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0986
    Cell Significance Index: -1.0400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0989
    Cell Significance Index: -1.0100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1005
    Cell Significance Index: -1.0800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1013
    Cell Significance Index: -0.9200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1044
    Cell Significance Index: -0.9900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1072
    Cell Significance Index: -0.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1082
    Cell Significance Index: -5.0500
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1092
    Cell Significance Index: -0.8900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1106
    Cell Significance Index: -1.4300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1126
    Cell Significance Index: -1.4800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1201
    Cell Significance Index: -0.9300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1233
    Cell Significance Index: -0.6600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1234
    Cell Significance Index: -0.7500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1273
    Cell Significance Index: -0.7900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1296
    Cell Significance Index: -1.5000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1381
    Cell Significance Index: -1.2700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1472
    Cell Significance Index: -0.9800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1503
    Cell Significance Index: -0.9300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1597
    Cell Significance Index: -1.0200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1642
    Cell Significance Index: -1.3900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1852
    Cell Significance Index: -1.0100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.2101
    Cell Significance Index: -2.0700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2312
    Cell Significance Index: -2.5100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2415
    Cell Significance Index: -2.4600
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.3105
    Cell Significance Index: -2.8400
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.6956
    Cell Significance Index: -6.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGKJ3 is a pseudogene, meaning that it has undergone a process of degeneration, resulting in a non-functional gene. Despite its pseudogenous state, IGKJ3 is still significantly expressed in various immune cells, including IgG plasmablasts, class-switched memory B cells, unswitched memory B cells, dendritic cells, erythrocytes, IgA plasmablasts, plasma cells, memory B cells, megakaryocytes, and plasmacytoid dendritic cells. The widespread expression of IGKJ3 suggests that it may have evolved to play a role in the regulation of immune responses or in the development of immune cells. **Pathways and Functions** IGKJ3 is involved in the V(D)J recombination process, a complex mechanism that generates diversity in the immune system by rearranging gene segments during B cell development. Although IGKJ3 is a pseudogene, it is thought to be a remnant of an ancient gene that was involved in this process. The gene is also potentially involved in the regulation of immune responses, as it is expressed in cells that produce antibodies, such as IgG plasmablasts and plasma cells. Furthermore, IGKJ3 has been implicated in the development of certain immune-related disorders, such as autoimmune diseases and cancer. For example, studies have shown that IGKJ3 is overexpressed in patients with multiple sclerosis, a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system. **Clinical Significance** The clinical significance of IGKJ3 is multifaceted. Firstly, its expression in various immune cells suggests that it may play a role in regulating immune responses and preventing autoimmune diseases. Secondly, its potential involvement in the development of cancer raises the possibility that IGKJ3 may serve as a prognostic marker for certain types of cancer. Furthermore, IGKJ3 may have therapeutic applications in the treatment of autoimmune diseases and cancer. For example, targeting IGKJ3 with specific antibodies or small molecules may help to modulate immune responses and prevent disease progression. Additionally, understanding the mechanisms by which IGKJ3 regulates immune responses may provide insights into the development of novel immunotherapies. In conclusion, IGKJ3 is a complex gene that plays a crucial role in the development and function of the human immune system. Its widespread expression in various immune cells and potential involvement in immune-related disorders make it a fascinating area of research. Further studies are needed to fully elucidate the mechanisms by which IGKJ3 regulates immune responses and to explore its therapeutic potential in the treatment of autoimmune diseases and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.