Details for: IFNA17

Gene ID: 3451

Symbol: IFNA17

Ensembl ID: ENSG00000234829

Description: interferon alpha 17

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10792.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7557
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3653
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.05
    Marker Score: 32663.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 740
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.45
    Marker Score: 145
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.33
    Marker Score: 87.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.25
    Marker Score: 145
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.21
    Marker Score: 81.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 80.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.18
    Marker Score: 286
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.17
    Marker Score: 92
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 86.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 75.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 64.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.15
    Marker Score: 85
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.14
    Marker Score: 292
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.13
    Marker Score: 88.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.13
    Marker Score: 254
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.12
    Marker Score: 83.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 68.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 86.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1
    Marker Score: 1516
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.09
    Marker Score: 48
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.09
    Marker Score: 88.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.09
    Marker Score: 56.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.08
    Marker Score: 495
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 87.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 85.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 66.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.07
    Marker Score: 102
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 73.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.07
    Marker Score: 81
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.07
    Marker Score: 88.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.06
    Marker Score: 252
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.04
    Marker Score: 74
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.03
    Marker Score: 62.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 80
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 110.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 63
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.02
    Marker Score: 109.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.02
    Marker Score: 80.5
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.01
    Marker Score: 97
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.01
    Marker Score: 84.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 81.5

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Other Information

**Key characteristics:** - IFNA17 is a member of the interferon alpha/beta family of cytokines. - It is produced by various cell types in response to infection or other stimuli. - It has both pro-inflammatory and anti-inflammatory effects, depending on the cellular context. - It plays a role in the regulation of inflammation, immune responses, and cell growth. **Pathways and functions:** - IFNA17 is involved in the regulation of innate immune responses. - It promotes the production of inflammatory cytokines, such as IL-1beta, IL-6, and TNF-alpha. - It also modulates the expression of immune checkpoint molecules, such as PD-L1 and CTLA-4. - It is involved in the regulation of adaptive immune responses. - It promotes the differentiation of mononuclear cells into macrophages and dendritic cells. - It also plays a role in the regulation of platelet production and function. **Clinical significance:** - Mutations in IFNA17 have been linked to the pathogenesis of several diseases, including cancer, autoimmune disorders, and respiratory infections. - Targeting IFNA17 has been investigated as a potential therapeutic strategy for these diseases. - However, the clinical efficacy of IFNA17 inhibitors is still being investigated. **Additional information:** - The gene encoding IFNA17 is located on chromosome 19q21.1. - It is a highly conserved protein, with a similar sequence in humans, mice, and rats. - It is a secreted protein that is produced and released by cells. - It is a potent activator of the JAK/STAT signaling pathway.

Genular Protein ID: 778275230

Symbol: IFN17_HUMAN

Name: Interferon alpha-17

UniProtKB Accession Codes:

P01571 Q14639 Q4KMT4 Q5VZ53 Q7M4Q4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 4 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6165082

Title: DNA sequence of two closely linked human leukocyte interferon genes.

PubMed ID: 6165082

DOI: 10.1126/science.6165082

PubMed ID: 3891272

Title: Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules.

PubMed ID: 3891272

DOI: 10.1089/dna.1985.4.221

PubMed ID: 3767336

Title: [Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons].

PubMed ID: 3767336

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4008999

Title: Differential expression of interferon genes in a substrain of Namalwa cells.

PubMed ID: 4008999

DOI: 10.1089/jir.1985.5.229

PubMed ID: 1634550

Title: Purification and characterization of multiple components of human lymphoblastoid interferon-alpha.

PubMed ID: 1634550

DOI: 10.1016/s0021-9258(18)42167-9

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 9712362

Title: A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major variant in human population.

PubMed ID: 9712362

DOI: 10.1089/jir.1998.18.469

Sequence Information:

  • Length: 189
  • Mass: 21728
  • Checksum: 0448EAEAB9D7FC32
  • Sequence:
    • MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF SCLKDRHDFG 
LPQEEFDGNQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNNLE 
ACVIQEVGME ETPLMNEDSI LAVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN 
LQKILRRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.