Details for: IFNA17

Gene ID: 3451

Symbol: IFNA17

Ensembl ID: ENSG00000234829

Description: interferon alpha 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1894
    Cell Significance Index: 3.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.1147
    Cell Significance Index: 2.9200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1073
    Cell Significance Index: 1.2300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0689
    Cell Significance Index: 1.1800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0582
    Cell Significance Index: 0.7500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0436
    Cell Significance Index: 0.4300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0102
    Cell Significance Index: 0.1100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0082
    Cell Significance Index: 0.1100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0054
    Cell Significance Index: 0.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0046
    Cell Significance Index: 0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0044
    Cell Significance Index: -0.8900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0086
    Cell Significance Index: -0.0900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0094
    Cell Significance Index: -0.1900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0147
    Cell Significance Index: -0.1600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0148
    Cell Significance Index: -0.1700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0255
    Cell Significance Index: -0.3000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0262
    Cell Significance Index: -0.3300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0290
    Cell Significance Index: -0.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0303
    Cell Significance Index: -0.5600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0315
    Cell Significance Index: -0.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0332
    Cell Significance Index: -0.3900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0337
    Cell Significance Index: -0.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0386
    Cell Significance Index: -1.2300
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0404
    Cell Significance Index: -0.4000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0404
    Cell Significance Index: -0.2400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0406
    Cell Significance Index: -0.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0454
    Cell Significance Index: -1.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0457
    Cell Significance Index: -0.9700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0475
    Cell Significance Index: -0.5000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0477
    Cell Significance Index: -0.6000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0486
    Cell Significance Index: -0.5000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0506
    Cell Significance Index: -0.6100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0588
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0628
    Cell Significance Index: -0.5900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0660
    Cell Significance Index: -0.8700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0695
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0716
    Cell Significance Index: -0.6700
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0739
    Cell Significance Index: -0.8400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0838
    Cell Significance Index: -0.7400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0856
    Cell Significance Index: -0.7900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0870
    Cell Significance Index: -0.8300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0976
    Cell Significance Index: -0.9300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1007
    Cell Significance Index: -1.2600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1205
    Cell Significance Index: -1.3500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1338
    Cell Significance Index: -1.4200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1588
    Cell Significance Index: -0.8500
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1708
    Cell Significance Index: -1.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFNA17 is a type I interferon, a class of cytokines that are essential for the host's defense against viral infections. It is structurally similar to other type I interferons, such as IFN-alpha and IFN-beta, but exhibits distinct differences in its expression profile and signaling mechanisms. IFNA17 is primarily produced in response to viral infections, particularly those caused by respiratory syncytial virus (RSV) and SARS-CoV-2. Its expression is also observed in various other cell types, including goblet cells, intestinal epithelial cells, and mononuclear cells. **Pathways and Functions:** IFNA17 is involved in several key pathways, including: 1. **Adaptive immune response:** IFNA17 plays a crucial role in regulating the adaptive immune response, particularly in the activation of natural killer cells and T cells. 2. **Cytokine-mediated signaling pathway:** IFNA17 interacts with its receptor, IFNAR, to initiate a signaling cascade that activates downstream transcription factors, such as IRF3 and IRF7. 3. **Type I interferon-mediated signaling pathway:** IFNA17 is a key component of the type I interferon-mediated signaling pathway, which is critical for the induction of antiviral genes and the production of other type I interferons. 4. **Cellular response to virus:** IFNA17 is essential for the host's response to viral infections, particularly in the induction of interferon-stimulated genes (ISGs) that inhibit viral replication. **Clinical Significance:** IFNA17's clinical significance is multifaceted: 1. **Viral infections:** IFNA17 is critical for the host's defense against viral infections, particularly those caused by RSV and SARS-CoV-2. 2. **Autoimmune diseases:** IFNA17 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where it may contribute to the dysregulation of the immune response. 3. **Cancer:** IFNA17 has been shown to have antitumor effects, particularly in the induction of ISGs that inhibit cancer cell proliferation and survival. 4. **Immunotherapy:** IFNA17 may have therapeutic potential in the treatment of viral infections and autoimmune diseases, particularly in combination with other immunotherapeutic strategies. **Significantly Expressed Cells:** IFNA17 is expressed in various cell types, including: 1. **Goblet cells:** IFNA17 is expressed in goblet cells, which are involved in the production of mucin, a key component of the mucus barrier. 2. **Neoplastic cells:** IFNA17 is expressed in neoplastic cells, suggesting its potential role in cancer development and progression. 3. **Abnormal cells:** IFNA17 is expressed in abnormal cells, such as those found in autoimmune diseases and cancer. 4. **Intestinal epithelial cells:** IFNA17 is expressed in intestinal epithelial cells, which are critical for the maintenance of the gut barrier function. In conclusion, IFNA17 is a crucial component of the interferon alpha/beta signaling pathway, playing a pivotal role in the innate immune response against viral infections. Its significant expression in various cell types and its involvement in multiple pathways highlight its importance in the immune system. Further research is necessary to fully elucidate the mechanisms underlying IFNA17's functions and to explore its therapeutic potential in the treatment of viral infections, autoimmune diseases, and cancer.

Genular Protein ID: 778275230

Symbol: IFN17_HUMAN

Name: Interferon alpha-17

UniProtKB Accession Codes:

P01571 Q14639 Q4KMT4 Q5VZ53 Q7M4Q4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 4 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6165082

Title: DNA sequence of two closely linked human leukocyte interferon genes.

PubMed ID: 6165082

DOI: 10.1126/science.6165082

PubMed ID: 3891272

Title: Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules.

PubMed ID: 3891272

DOI: 10.1089/dna.1985.4.221

PubMed ID: 3767336

Title: [Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons].

PubMed ID: 3767336

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4008999

Title: Differential expression of interferon genes in a substrain of Namalwa cells.

PubMed ID: 4008999

DOI: 10.1089/jir.1985.5.229

PubMed ID: 1634550

Title: Purification and characterization of multiple components of human lymphoblastoid interferon-alpha.

PubMed ID: 1634550

DOI: 10.1016/s0021-9258(18)42167-9

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 9712362

Title: A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major variant in human population.

PubMed ID: 9712362

DOI: 10.1089/jir.1998.18.469

Sequence Information:

  • Length: 189
  • Mass: 21728
  • Checksum: 0448EAEAB9D7FC32
  • Sequence:
    • MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF SCLKDRHDFG 
LPQEEFDGNQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNNLE 
ACVIQEVGME ETPLMNEDSI LAVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN 
LQKILRRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.