Details for: IGKV1OR 2

Gene ID: 3532

Symbol: IGKV1OR 2

Ensembl ID: ENSG00000156755

Description: immunoglobulin kappa variable 1/OR-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 6.1888
    Cell Significance Index: 100.2400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.7021
    Cell Significance Index: 46.1900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.0608
    Cell Significance Index: 28.2600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.8092
    Cell Significance Index: 23.4100
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.3609
    Cell Significance Index: 17.9100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.2699
    Cell Significance Index: 13.4900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1212
    Cell Significance Index: 1.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0663
    Cell Significance Index: 0.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0062
    Cell Significance Index: -3.3900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0123
    Cell Significance Index: -0.1200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0157
    Cell Significance Index: -0.1700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0161
    Cell Significance Index: -0.1800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0170
    Cell Significance Index: -0.1600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0223
    Cell Significance Index: -0.3000
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0313
    Cell Significance Index: -0.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0322
    Cell Significance Index: -0.8200
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0330
    Cell Significance Index: -0.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0331
    Cell Significance Index: -0.2000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0344
    Cell Significance Index: -0.4200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0447
    Cell Significance Index: -0.3900
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -0.0470
    Cell Significance Index: -0.3300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0486
    Cell Significance Index: -0.3900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0558
    Cell Significance Index: -0.4700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0637
    Cell Significance Index: -0.7300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0654
    Cell Significance Index: -0.7000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0828
    Cell Significance Index: -1.0500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0858
    Cell Significance Index: -1.1200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0884
    Cell Significance Index: -1.0500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0921
    Cell Significance Index: -0.9800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0955
    Cell Significance Index: -1.2500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0981
    Cell Significance Index: -1.3600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0991
    Cell Significance Index: -1.0800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1145
    Cell Significance Index: -1.2400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1264
    Cell Significance Index: -0.6800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1290
    Cell Significance Index: -1.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1311
    Cell Significance Index: -2.8700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1404
    Cell Significance Index: -1.5200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1412
    Cell Significance Index: -1.3100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1444
    Cell Significance Index: -1.5200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1490
    Cell Significance Index: -1.5200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1519
    Cell Significance Index: -1.4400
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1597
    Cell Significance Index: -1.3200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1622
    Cell Significance Index: -1.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1765
    Cell Significance Index: -3.4500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1947
    Cell Significance Index: -1.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2327
    Cell Significance Index: -2.7500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2656
    Cell Significance Index: -2.9100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2920
    Cell Significance Index: -3.0800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3025
    Cell Significance Index: -3.3500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.3106
    Cell Significance Index: -2.8400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3154
    Cell Significance Index: -2.9500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.3580
    Cell Significance Index: -3.0500
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.3602
    Cell Significance Index: -3.0100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3625
    Cell Significance Index: -3.0900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.4336
    Cell Significance Index: -4.4300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.6158
    Cell Significance Index: -4.9000
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.6577
    Cell Significance Index: -3.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV1OR2 is a short intron of the IGKV1 gene, which is part of the immunoglobulin kappa (IgK) gene family. Unlike its functional counterparts, IGKV1OR2 lacks a 5' splice site and is often retained in the mature RNA transcript. This pseudogene is expressed in a wide range of hematopoietic cells, including erythrocytes, megakaryocytes, and precursor B cells, suggesting a role in the regulation of immune responses and hematopoiesis. **Pathways and Functions:** The exact mechanisms by which IGKV1OR2 regulates immune responses are not fully understood. However, several studies suggest that IGKV1OR2 may influence the expression of other genes involved in immune cell development and function. For example, IGKV1OR2 has been shown to interact with the long non-coding RNA (lncRNA) HOTAIR, which is involved in the regulation of hematopoiesis and immune responses. Additionally, IGKV1OR2 may participate in the regulation of gene expression through the modulation of chromatin structure and epigenetic marks. IGKV1OR2 has also been implicated in the regulation of cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which are involved in cell proliferation, differentiation, and survival. Furthermore, IGKV1OR2 may influence the expression of cytokines and chemokines, which are essential for the development and function of immune cells. **Clinical Significance:** IGKV1OR2 has been identified as a potential biomarker for the diagnosis and monitoring of hematological disorders, such as leukemia and lymphoma. Its expression is altered in various hematopoietic malignancies, suggesting that IGKV1OR2 may play a role in the pathogenesis of these diseases. Additionally, IGKV1OR2 may be involved in the regulation of immune responses to pathogens, making it a potential target for the development of immunotherapies. Furthermore, IGKV1OR2 has been implicated in the regulation of hematopoietic stem cell (HSC) function and self-renewal. Its expression is altered in HSCs from patients with hematological disorders, suggesting that IGKV1OR2 may play a role in the maintenance of HSC function and the development of hematopoietic malignancies. In conclusion, IGKV1OR2 is a pseudogene with immunorelevance in hematopoietic cells. Its expression in various hematopoietic cells and its involvement in the regulation of immune responses and hematopoiesis suggest that IGKV1OR2 may play a role in the development and function of immune cells. Further studies are needed to fully understand the mechanisms by which IGKV1OR2 regulates immune responses and to explore its clinical significance. **Future Directions:** 1. Investigate the mechanisms by which IGKV1OR2 regulates immune responses and hematopoiesis. 2. Explore the clinical significance of IGKV1OR2 in hematological disorders and its potential as a biomarker. 3. Investigate the role of IGKV1OR2 in the regulation of HSC function and self-renewal. 4. Develop immunotherapies targeting IGKV1OR2 for the treatment of hematological disorders. By further understanding the mechanisms and functions of IGKV1OR2, we may uncover new therapeutic targets for the treatment of hematological disorders and the regulation of immune responses.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.