**Key characteristics:**
- The IGKV1OR2 gene is located on chromosome 1 and is approximately 1.2 million base pairs long.
- The gene is expressed in high levels in cells of the immune system, particularly in lymphoid tissues.
- The protein encoded by IGKV1OR2 is a member of the immunoglobulin kappa family of antibodies.
- The protein is expressed on the surface of immune cells and is involved in the regulation of immune responses.
**Pathways and functions:**
- The IGKV1OR2 protein is a key regulator of T cell activation.
- It is expressed in high levels in thymocytes, which are responsible for the development and maintenance of T cell immunity.
- The protein helps to control the differentiation and survival of T cells.
- It also plays a role in the regulation of B cell activation and differentiation.
- In addition, the IGKV1OR2 protein is expressed on the surface of mast cells, where it helps to regulate the release of histamine and other inflammatory mediators.
**Clinical significance:**
- Mutations in the IGKV1OR2 gene have been linked to a number of human diseases, including autoimmune disorders, inflammatory diseases, and cancer.
- The protein encoded by IGKV1OR2 is a potential target for therapeutic intervention in these diseases.
- By blocking the activity of the IGKV1OR2 protein, it may be possible to treat autoimmune disorders and other diseases characterized by excessive inflammation.
Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
