Details for: TRGVB

Gene ID: 6987

Symbol: TRGVB

Ensembl ID: ENSG00000231202

Description: T cell receptor gamma variable B (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0739
    Cell Significance Index: 0.7800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0538
    Cell Significance Index: 0.7200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0430
    Cell Significance Index: 0.4500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.0394
    Cell Significance Index: 0.3300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.0137
    Cell Significance Index: 0.0700
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0030
    Cell Significance Index: 0.0400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0027
    Cell Significance Index: 0.0300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0060
    Cell Significance Index: -0.0700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0071
    Cell Significance Index: -0.1000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0141
    Cell Significance Index: -0.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0154
    Cell Significance Index: -0.1800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0170
    Cell Significance Index: -0.1600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0178
    Cell Significance Index: -0.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0179
    Cell Significance Index: -0.3300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0186
    Cell Significance Index: -0.2000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0187
    Cell Significance Index: -0.2400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0188
    Cell Significance Index: -0.2100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0188
    Cell Significance Index: -0.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0194
    Cell Significance Index: -0.2400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0203
    Cell Significance Index: -0.3400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0227
    Cell Significance Index: -0.2000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0231
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0241
    Cell Significance Index: -0.3000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0242
    Cell Significance Index: -0.2600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0244
    Cell Significance Index: -0.2700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0257
    Cell Significance Index: -0.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0260
    Cell Significance Index: -0.2500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0269
    Cell Significance Index: -0.2500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0271
    Cell Significance Index: -0.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0279
    Cell Significance Index: -0.3300
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0285
    Cell Significance Index: -0.3300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0321
    Cell Significance Index: -0.3000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0337
    Cell Significance Index: -0.4400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0348
    Cell Significance Index: -0.4000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0375
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0391
    Cell Significance Index: -0.3200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0393
    Cell Significance Index: -0.3500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0396
    Cell Significance Index: -0.4100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0401
    Cell Significance Index: -0.3800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0415
    Cell Significance Index: -0.2700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0418
    Cell Significance Index: -0.2900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0421
    Cell Significance Index: -0.4200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0436
    Cell Significance Index: -0.3400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0505
    Cell Significance Index: -0.3200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0532
    Cell Significance Index: -0.2900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0548
    Cell Significance Index: -0.4500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0822
    Cell Significance Index: -0.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRGVB is significantly expressed in epithelial cells, myeloid cells, prostate epithelial luminal cells, effector CD8-positive alpha-beta T cells, malignant cells, mast cells, mature NK T cells, innate lymphoid cells, oligodendrocyte precursor cells, and glutamatergic neurons. This widespread expression suggests a multifaceted role in various biological processes. 2. **Pseudogenic Nature:** TRGVB is classified as a pseudogene, meaning it lacks functional coding potential. However, its expression and potential regulatory functions cannot be entirely discounted. 3. **Cell Type-Specific Expression:** The expression of TRGVB in specific cell types, such as epithelial cells and mast cells, hints at a specialized function in these cells. **Pathways and Functions:** 1. **Immunological Signaling:** TRGVB's expression in effector CD8-positive alpha-beta T cells and mast cells suggests a potential involvement in immunological signaling pathways. These cells are crucial for the adaptive immune response, and TRGVB's expression may modulate their function. 2. **Cellular Differentiation:** TRGVB's expression in oligodendrocyte precursor cells and glutamatergic neurons implies a role in cellular differentiation processes. This could involve regulating the expression of genes involved in neuronal development and function. 3. **Apoptosis and Cell Survival:** TRGVB's expression in malignant cells may be related to apoptosis and cell survival pathways. Its pseudogenic nature could potentially influence the regulation of these processes, impacting cancer progression. **Clinical Significance:** 1. **Cancer Research:** TRGVB's expression in malignant cells raises questions about its potential role in cancer development and progression. Further studies are needed to determine whether TRGVB is a tumor suppressor or oncogene. 2. **Immunological Disorders:** TRGVB's expression in effector CD8-positive alpha-beta T cells and mast cells suggests a potential involvement in immunological disorders, such as autoimmune diseases or allergies. Understanding TRGVB's function could lead to the development of novel therapeutic strategies. 3. **Neurological Disorders:** TRGVB's expression in oligodendrocyte precursor cells and glutamatergic neurons implies a potential role in neurological disorders, such as multiple sclerosis or Alzheimer's disease. Further research is needed to determine the relevance of TRGVB in these conditions. In conclusion, the TRGVB gene, despite its pseudogenic nature, exhibits a complex expression profile that highlights its potential involvement in various immunological and cellular processes. Further research is necessary to fully elucidate the functions and clinical significance of TRGVB, but its study has the potential to reveal new insights into the biology of immune cells, cancer, and neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.