Details for: TFEB

Gene ID: 7942

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TFEB

Ensembl ID: ENSG00000112561

Description: transcription factor EB

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • intermediate monocyte CL0002393
    CSI 6.92
    rCSI 10.44%
    PRS 92.49
  • plasmablast CL0000980
    CSI 3.86
    rCSI 3.04%
    PRS 91.15
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 3.85
    rCSI 8.78%
    PRS 81.54
  • type B pancreatic cell CL0000169
    CSI 3.79
    rCSI 8.4%
    PRS 88.29
  • ionocyte CL0005006
    CSI 3.37
    rCSI 3.62%
    PRS 90.06
  • unswitched memory B cell CL0000970
    CSI 3.23
    rCSI 2.71%
    PRS 96.46
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.21
    rCSI 3.99%
    PRS 71.81
  • regular atrial cardiac myocyte CL0002129
    CSI 3.08
    rCSI 9.92%
    PRS 84.97
  • renal alpha-intercalated cell CL0005011
    CSI 3.08
    rCSI 4.12%
    PRS 92.21
  • class switched memory B cell CL0000972
    CSI 3.06
    rCSI 2.28%
    PRS 95.74
  • Kupffer cell CL0000091
    CSI 2.88
    rCSI 6.57%
    PRS 89.29
  • immature B cell CL0000816
    CSI 2.84
    rCSI 2.11%
    PRS 95.01
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.84
    rCSI 3.39%
    PRS 74.1
  • pancreatic A cell CL0000171
    CSI 2.75
    rCSI 2.88%
    PRS 90.53
  • secretory cell CL0000151
    CSI 2.66
    rCSI 2.77%
    PRS 87.2
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.53
    rCSI 6.6%
    PRS 89.64
  • lung neuroendocrine cell CL1000223
    CSI 2.53
    rCSI 3.74%
    PRS 90.45
  • pulmonary ionocyte CL0017000
    CSI 2.51
    rCSI 3.05%
    PRS 92.57
  • Mueller cell CL0000636
    CSI 2.42
    rCSI 5.51%
    PRS 81.28
  • mature B cell CL0000785
    CSI 2.4
    rCSI 2.09%
    PRS 94.79
  • ciliated cell CL0000064
    CSI 2.38
    rCSI 3.86%
    PRS 82.83
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.35
    rCSI 3.75%
    PRS 91.14
  • cerebral cortex endothelial cell CL1001602
    CSI 2.33
    rCSI 4.03%
    PRS 82.29
  • conjunctival epithelial cell CL1000432
    CSI 2.2
    rCSI 3.36%
    PRS 87.68
  • duct epithelial cell CL0000068
    CSI 2.18
    rCSI 3.19%
    PRS 92.13
  • myeloid leukocyte CL0000766
    CSI 2.16
    rCSI 2%
    PRS 89.43
  • intestinal epithelial cell CL0002563
    CSI 2.06
    rCSI 2.15%
    PRS 86.07
  • common dendritic progenitor CL0001029
    CSI 2.02
    rCSI 2.53%
    PRS 93.96
  • colon epithelial cell CL0011108
    CSI 1.95
    rCSI 2.04%
    PRS 85.93
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.82
    rCSI 4.71%
    PRS 85
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.82
    rCSI 1.4%
    PRS 91.45
  • mononuclear phagocyte CL0000113
    CSI 1.67
    rCSI 3.68%
    PRS 90.98
  • renal beta-intercalated cell CL0002201
    CSI 1.63
    rCSI 3.88%
    PRS 88.33
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.52
    rCSI 3.86%
    PRS 81.26
  • lung macrophage CL1001603
    CSI 1.42
    rCSI 3.17%
    PRS 93.1
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.42
    rCSI 3.17%
    PRS 74.63
  • cardiac muscle cell CL0000746
    CSI 1.34
    rCSI 1.92%
    PRS 79.91
  • placental villous trophoblast CL2000060
    CSI 1.31
    rCSI 2.03%
    PRS 86.98
  • parietal epithelial cell CL1000452
    CSI 1.29
    rCSI 3.44%
    PRS 82.19
  • transitional stage B cell CL0000818
    CSI 1.26
    rCSI 4.12%
    PRS 96.48
  • melanocyte of skin CL1000458
    CSI 0.86
    rCSI 1.17%
    PRS 57.97
  • follicular B cell CL0000843
    CSI 0.78
    rCSI 2.85%
    PRS 95.94
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.63
    rCSI 3.91%
    PRS 81.53
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.59
    rCSI 2.13%
    PRS 71.96

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [TFEB](/details-gene/7942), or Transcription Factor EB, is a protein-coding gene located on chromosome 6p21.1. It is a member of the basic helix-loop-helix leucine zipper family of transcription factors ([Link](https://doi.org/10.1101/gad.5.12a.2342)). [TFEB](/details-gene/7942) is widely recognized as a master regulator of lysosomal biogenesis, autophagy, and cellular homeostasis. It integrates signals about the cell's metabolic state, particularly through the mTORC1 pathway, to control the expression of a broad network of genes involved in cellular clearance and recycling ([Link](https://doi.org/10.1126/science.1174447), [Link](https://doi.org/10.1038/emboj.2012.32)). **Overall**, expression data reveals its high significance in metabolically active immune cells, such as the [intermediate monocyte](/details-cell/CL0002393), and in various secretory and specialized cell types, underscoring its fundamental role in maintaining organelle quality control across diverse tissues. Deficiencies or dysregulation of [TFEB](/details-gene/7942) are associated with human disease, as indicated by its OMIM annotation ([600744](https://omim.org/entry/600744)). ## Cellular Roles and Expression Landscape The expression profile of [TFEB](/details-gene/7942) highlights its critical function in a wide array of cell types, with a notable prominence in the immune system. The highest significance is observed in the [intermediate monocyte](/details-cell/CL0002393) (CSI: 6.92), suggesting a key role in monocyte function, differentiation, or response to inflammatory cues. This immune-centric role is further supported by high CSI scores in multiple B-lineage cells, including [plasmablast](/details-cell/CL0000980), [unswitched memory B cell](/details-cell/CL0000970), [class switched memory B cell](/details-cell/CL0000972), and [immature B cell](/details-cell/CL0000816). This pattern is consistent with the high metabolic and protein synthesis demands of antibody production and immune memory maintenance. Additionally, its significance in [Kupffer cell](/details-cell/CL0000091)s, the resident macrophages of the liver, aligns with their intense phagocytic and catabolic activity. Beyond the immune system, [TFEB](/details-gene/7942) demonstrates significant expression in cells characterized by high secretory activity or specialized ion transport functions. This includes [ciliated columnar cell of tracheobronchial tree](/details-cell/CL0002145), [type B pancreatic cell](/details-cell/CL0000169), [ionocyte](/details-cell/CL0005006), and [renal alpha-intercalated cell](/details-cell/CL0005011). This broad but specific expression pattern suggests that while [TFEB](/details-gene/7942) is a ubiquitous regulator of cellular homeostasis, its activity is particularly crucial in cell types that experience high levels of metabolic stress, protein turnover, or organelle processing. ## Pathways and Molecular Function Functionally, [TFEB](/details-gene/7942) operates as a [Dna-binding transcription factor activity, rna polymerase ii-specific](/details-cell/GO:0000981), controlling gene expression by binding to specific DNA sequences in cis-regulatory regions. Its central biological role is the coordination of the cellular response to stress, particularly starvation. This is evidenced by its involvement in GO processes such as '[Cellular response to starvation](/details-cell/GO:0009267)', '[Positive regulation of autophagy](/details-cell/GO:0010508)', and '[Lysosome organization](/details-cell/GO:0007040)'. Under nutrient-rich conditions, mTORC1 phosphorylates [TFEB](/details-gene/7942), retaining it in the [Cytoplasm](/details-cell/GO:0005737). Upon starvation or lysosomal stress, mTORC1 is inactivated, leading to dephosphorylation of [TFEB](/details-gene/7942) and its translocation to the [Nucleus](/details-cell/GO:0005634) where it activates the transcription of genes involved in lysosomal biogenesis and autophagy ([Link](https://doi.org/10.1126/scisignal.2002790)). This master regulatory function is consistent with its annotated involvement in the '[Adaptive immune response](/details-cell/GO:0002250)' and '[Humoral immune response](/details-cell/GO:0006959)'. Autophagy is critical for antigen presentation, removal of intracellular pathogens, and the metabolic reprogramming required for lymphocyte activation and differentiation into effector and memory cells. Thus, the high expression of [TFEB](/details-gene/7942) in monocytes and B-cell lineages likely reflects its role in orchestrating the lysosomal and autophagic machinery necessary for robust immune function. ## Research Directions The widespread yet specific expression pattern of [TFEB](/details-gene/7942) across metabolically active cell types suggests several avenues for future research. Its role as a central hub integrating metabolic state with gene expression makes it a critical factor in both physiological and pathological processes. **Proposed Hypotheses:** 1. Given its high significance in [intermediate monocyte](/details-cell/CL0002393)s and [Kupffer cell](/details-cell/CL0000091)s, [TFEB](/details-gene/7942) activity is essential for macrophage polarization and phagocytic capacity. Its activation may be a key event in shifting macrophages towards a more catabolic and anti-inflammatory phenotype by enhancing lysosomal clearance of cellular debris and pathogens. 2. In secretory cells like pancreatic beta cells ([type B pancreatic cell](/details-cell/CL0000169)), [TFEB](/details-gene/7942)-mediated autophagy is a critical quality control mechanism to clear misfolded proinsulin and damaged organelles, thereby preventing the endoplasmic reticulum stress that contributes to beta-cell failure in type 2 diabetes. **Experimental Approach:** To test the first hypothesis regarding the role of [TFEB](/details-gene/7942) in macrophage function, one could utilize a conditional knockout mouse model with [TFEB](/details-gene/7942) deleted specifically in the myeloid lineage (e.g., Lyz2-Cre;Tfeb-flox/flox). Bone marrow-derived macrophages (BMDMs) from these mice and wild-type controls could be polarized *in vitro* towards M1 (pro-inflammatory) and M2 (anti-inflammatory) phenotypes. The impact of [TFEB](/details-gene/7942) deletion would be assessed by RNA-sequencing to measure changes in polarization markers and metabolic gene expression, alongside functional assays measuring phagocytosis, efferocytosis (clearance of apoptotic cells), and cytokine production. **Therapeutic Potential:** [TFEB](/details-gene/7942) represents a highly attractive therapeutic target, primarily for strategies involving its **activation**. As a master regulator of cellular clearance, enhancing [TFEB](/details-gene/7942) activity could be beneficial for diseases characterized by the accumulation of toxic aggregates, such as lysosomal storage disorders and neurodegenerative diseases like Alzheimer's and Parkinson's. Because transcription factors are challenging to target directly with small molecules, therapeutic efforts would likely focus on modulating upstream pathways, such as inhibiting its inhibitor mTORC1, or on developing gene therapies to increase its expression. Such an approach could restore cellular homeostasis and clear pathological protein aggregates.

Genular Protein ID: 2184425737

Symbol: TFEB_HUMAN

Name: Class E basic helix-loop-helix protein 35

UniProtKB Accession Codes:

P19484 Q709B3 Q7Z6P9 Q9BRJ5 Q9UJD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 3 Ensembl 13 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 11 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2115126

Title: A helix-loop-helix protein related to the immunoglobulin E box-binding proteins.

PubMed ID: 2115126

DOI: 10.1128/mcb.10.8.4384-4388.1990

PubMed ID: 15118077

Title: Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains.

PubMed ID: 15118077

DOI: 10.1093/nar/gkh571

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1748288

Title: TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine-zipper family.

PubMed ID: 1748288

DOI: 10.1101/gad.5.12a.2342

PubMed ID: 15507434

Title: Sumoylation of MITF and its related family members TFE3 and TFEB.

PubMed ID: 15507434

DOI: 10.1074/jbc.m411757200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19556463

Title: A gene network regulating lysosomal biogenesis and function.

PubMed ID: 19556463

DOI: 10.1126/science.1174447

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21617040

Title: TFEB links autophagy to lysosomal biogenesis.

PubMed ID: 21617040

DOI: 10.1126/science.1204592

PubMed ID: 22576015

Title: MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

PubMed ID: 22576015

DOI: 10.4161/auto.19653

PubMed ID: 22343943

Title: A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.

PubMed ID: 22343943

DOI: 10.1038/emboj.2012.32

PubMed ID: 22692423

Title: The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.

PubMed ID: 22692423

DOI: 10.1126/scisignal.2002790

PubMed ID: 23401004

Title: Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes.

PubMed ID: 23401004

DOI: 10.1083/jcb.201209135

PubMed ID: 24081491

Title: Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases.

PubMed ID: 24081491

DOI: 10.1083/jcb.201307084

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23434374

Title: ZKSCAN3 is a master transcriptional repressor of autophagy.

PubMed ID: 23434374

DOI: 10.1016/j.molcel.2013.01.024

PubMed ID: 25720963

Title: Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.

PubMed ID: 25720963

DOI: 10.1038/ncb3114

PubMed ID: 27184844

Title: An evolutionarily conserved PLC-PKD-TFEB pathway for host defense.

PubMed ID: 27184844

DOI: 10.1016/j.celrep.2016.04.052

PubMed ID: 27278822

Title: The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway.

PubMed ID: 27278822

DOI: 10.1038/ncomms11803

PubMed ID: 28552616

Title: Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.

PubMed ID: 28552616

DOI: 10.1016/j.molcel.2017.04.026

PubMed ID: 29146937

Title: TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.

PubMed ID: 29146937

DOI: 10.1038/s41467-017-01871-z

PubMed ID: 30120233

Title: mTOR-dependent phosphorylation controls TFEB nuclear export.

PubMed ID: 30120233

DOI: 10.1038/s41467-018-05862-6

PubMed ID: 31672913

Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.

PubMed ID: 31672913

DOI: 10.1126/science.aax0364

PubMed ID: 32612235

Title: A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome.

PubMed ID: 32612235

DOI: 10.1038/s41586-020-2444-0

PubMed ID: 32753672

Title: Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens.

PubMed ID: 32753672

DOI: 10.1038/s41556-020-0549-1

PubMed ID: 33691586

Title: Coxsackievirus B3 targets TFEB to disrupt lysosomal function.

PubMed ID: 33691586

DOI: 10.1080/15548627.2021.1896925

PubMed ID: 35662396

Title: Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.

PubMed ID: 35662396

DOI: 10.1016/j.molcel.2022.05.009

PubMed ID: 34071043

Title: TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagCS75Y Cardiomyopathy.

PubMed ID: 34071043

DOI: 10.3390/ijms22115494

PubMed ID: 37057673

Title: De novo missense variants in RRAGC lead to a fatal mTORopathy of early childhood.

PubMed ID: 37057673

DOI: 10.1016/j.gim.2023.100838

PubMed ID: 37079666

Title: Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1.

PubMed ID: 37079666

DOI: 10.1126/science.abj5559

PubMed ID: 36697823

Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.

PubMed ID: 36697823

DOI: 10.1038/s41586-022-05652-7

PubMed ID: 36749723

Title: A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB.

PubMed ID: 36749723

DOI: 10.1073/pnas.2213670120

Sequence Information:

  • Length: 476
  • Mass: 52865
  • Checksum: 093AE3B79C760D99
  • Sequence:
    • MASRIGLRMQ LMREQAQQEE QRERMQQQAV MHYMQQQQQQ QQQQLGGPPT PAINTPVHFQ 
SPPPVPGEVL KVQSYLENPT SYHLQQSQHQ KVREYLSETY GNKFAAHISP AQGSPKPPPA 
ASPGVRAGHV LSSSAGNSAP NSPMAMLHIG SNPERELDDV IDNIMRLDDV LGYINPEMQM 
PNTLPLSSSH LNVYSSDPQV TASLVGVTSS SCPADLTQKR ELTDAESRAL AKERQKKDNH 
NLIERRRRFN INDRIKELGM LIPKANDLDV RWNKGTILKA SVDYIRRMQK DLQKSRELEN 
HSRRLEMTNK QLWLRIQELE MQARVHGLPT TSPSGMNMAE LAQQVVKQEL PSEEGPGEAL 
MLGAEVPDPE PLPALPPQAP LPLPTQPPSP FHHLDFSHSL SFGGREDEGP PGYPEPLAPG 
HGSPFPSLSK KDLDLMLLDD SLLPLASDPL LSTMSPEASK ASSRRSSFSM EEGDVL

Genular Protein ID: 1772392545

Symbol: B0QYS6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0QYS6

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 490
  • Mass: 54223
  • Checksum: CCA1FFDFD0A0E2B0
  • Sequence:
    • MTASSGWEPA PAATMASRIG LRMQLMREQA QQEEQRERMQ QQAVMHYMQQ QQQQQQQQLG 
GPPTPAINTP VHFQSPPPVP GEVLKVQSYL ENPTSYHLQQ SQHQKVREYL SETYGNKFAA 
HISPAQGSPK PPPAASPGVR AGHVLSSSAG NSAPNSPMAM LHIGSNPERE LDDVIDNIMR 
LDDVLGYINP EMQMPNTLPL SSSHLNVYSS DPQVTASLVG VTSSSCPADL TQKRELTDAE 
SRALAKERQK KDNHNLIERR RRFNINDRIK ELGMLIPKAN DLDVRWNKGT ILKASVDYIR 
RMQKDLQKSR ELENHSRRLE MTNKQLWLRI QELEMQARVH GLPTTSPSGM NMAELAQQVV 
KQELPSEEGP GEALMLGAEV PDPEPLPALP PQAPLPLPTQ PPSPFHHLDF SHSLSFGGRE 
DEGPPGYPEP LAPGHGSPFP SLSKKDLDLM LLDDSLLPLA SDPLLSTMSP EASKASSRRS 
SFSMEEGDVL